Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer’s disease pathologies in 5XFAD transgenic mouse model

Currently, no effective therapeutics exist for the treatment of incurable neurodegenerative diseases such as Alzheimer’s disease (AD). The cellular prion protein (PrP C ) acts as a high-affinity receptor for amyloid beta oligomers (AβO), a main neurotoxic species mediating AD pathology. The interact...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2023-06, Vol.80 (6), p.139-139, Article 139
Hauptverfasser:	Ali, Tahir, Klein, Antonia N., Vu, Alex, Arifin, Maria I., Hannaoui, Samia, Gilch, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Apoptosis Aptamers Aptamers, Peptide Binding Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Disease Models, Animal Fyn protein Gliosis Health services Hippocampus Inflammation Kinases Life Sciences Mice Mice, Transgenic Neuroblastoma Neurodegenerative diseases Neurotoxicity Original Original Article Peptides Phosphorylation Prion protein Protein-tyrosine kinase Proteins PrPC Proteins - metabolism Senile plaques Thioredoxin Transgenic mice Tyrosine
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