The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Abstract The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a nine-subunit core and a distributive 3′ to 5′ exonuclease EXOSC10, plays a critical role in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research 2023-05, Vol.51 (8), p.3934-3949
Hauptverfasser:	Chen, Yingxiao, Li, Yanping, Dai, Roselyn S, Savage, Jonathan C, Shinde, Ujwal, Klimek, John, David, Larry L, Young, Emma A, Hafner, Markus, Sears, Rosalie C, Sun, Xiao-Xin, Dai, Mu-Shui
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Nucleolus - genetics Cell Nucleolus - metabolism Exoribonucleases - genetics Exoribonucleases - metabolism Exosome Multienzyme Ribonuclease Complex - genetics Exosome Multienzyme Ribonuclease Complex - metabolism Humans RNA - metabolism RNA and RNA-protein complexes RNA Precursors - genetics RNA Precursors - metabolism RNA Processing, Post-Transcriptional RNA, Ribosomal - genetics RNA, Ribosomal - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!