Bleeding Diathesis as the Initial Presentation of Chronic Myeloid Leukemia: A Case Series
Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37201 |
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| creator | AlGahtani, Farjah H Alshaman, Leena ElGohary, Ghada Aleem, Aamer AlQahtany, Fatmah S |
| description | Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations. |
| doi_str_mv | 10.7759/cureus.37201 |
| format | Article |
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The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.37201</identifier><identifier>PMID: 37159792</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Abdomen ; Blood ; Blood platelets ; Bone marrow ; Elbow ; Emergency medical care ; Hematology ; Hematoma ; Hemorrhage ; Kinases ; Leukemia ; Oncology ; Ophthalmology ; Ostomy ; Pathology ; Patients ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37201</ispartof><rights>Copyright © 2023, AlGahtani et al.</rights><rights>Copyright © 2023, AlGahtani et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, AlGahtani et al. 2023 AlGahtani et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-65dbffc88c61958b8d245277e60ee0f7d1a53e9b9080c6bc8c463b3f16e2f9203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163831/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163831/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37159792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AlGahtani, Farjah H</creatorcontrib><creatorcontrib>Alshaman, Leena</creatorcontrib><creatorcontrib>ElGohary, Ghada</creatorcontrib><creatorcontrib>Aleem, Aamer</creatorcontrib><creatorcontrib>AlQahtany, Fatmah S</creatorcontrib><title>Bleeding Diathesis as the Initial Presentation of Chronic Myeloid Leukemia: A Case Series</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. 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| subjects | Abdomen Blood Blood platelets Bone marrow Elbow Emergency medical care Hematology Hematoma Hemorrhage Kinases Leukemia Oncology Ophthalmology Ostomy Pathology Patients Ultrasonic imaging Veins & arteries |
| title | Bleeding Diathesis as the Initial Presentation of Chronic Myeloid Leukemia: A Case Series |
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