BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site

The large-conductance, Ca2+-, and voltage-activated K+ (BK) channel consists of the pore-forming α (BKα) subunit and regulatory β and γ subunits. The γ1-3 subunits facilitate BK channel activation by shifting the voltage-dependence of channel activation toward the hyperpolarization direction by abou...

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Veröffentlicht in:	The Journal of general physiology 2023-06, Vol.155 (6)
Hauptverfasser:	Chen, Guanxing, Li, Qin, Webb, Timothy I, Hollywood, Mark A, Yan, Jiusheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysics Calcium Calcium channels (voltage-gated) Calcium conductance Channel gating Electrostatic properties HIV Human immunodeficiency virus Hyperpolarization Intracellular Ion Channel Gating - physiology Ionic strength Ions Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism Large-Conductance Calcium-Activated Potassium Channels - metabolism Molecular Pharmacology Molecular Physiology Peptides Peptides - pharmacology Potassium channels (voltage-gated) Protein Subunits - metabolism Synthetic peptides Tat protein
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