Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration

Abstract Age-related macular degeneration (AMD) is the most prevalent cause of blindness in the developed world. Vision loss in the advanced stages of the disease is caused by atrophy of retinal photoreceptors, overlying retinal pigment epithelium (RPE) and choroidal endothelial cells. The molecular...

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Veröffentlicht in:	Human molecular genetics 2023-05, Vol.32 (10), p.1698-1710
Hauptverfasser:	Collin, Joseph, Hasoon, Megan S R, Zerti, Darin, Hammadi, Sarah, Dorgau, Birthe, Clarke, Lucy, Steel, David, Hussain, Rafiqul, Coxhead, Jonathan, Lisgo, Steven, Queen, Rachel, Lako, Majlinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Choroid - metabolism Endothelial Cells - metabolism Fetal Development Humans Macular Degeneration - genetics Macular Degeneration - metabolism Original Retinal Pigment Epithelium - metabolism Sequence Analysis, RNA
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