Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR

Background Mutations in the clonal hematopoiesis of indeterminate potential (CHIP)-driver genes DNMT3A and TET2 have been previously shown to be associated with short-term prognosis in patients undergoing TAVR for aortic valve stenosis. We aimed to extend and characterize these findings on long-term...

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Veröffentlicht in:	Clinical research in cardiology 2023-05, Vol.112 (5), p.585-593
Hauptverfasser:	Mas-Peiro, Silvia, Pergola, Graziella, Berkowitsch, Alexander, Meggendorfer, Manja, Rieger, Michael A., Vasa-Nicotera, Mariuca, Dimmeler, Stefanie, Zeiher, Andreas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta Aortic stenosis Aortic Valve Aortic Valve Stenosis - genetics Aortic Valve Stenosis - surgery Blood Cardiology Clonal Hematopoiesis Deoxyribonucleic acid DNA DNA methylation Female Follow-Up Studies Heart valves Hematopoiesis Hemopoiesis Humans Medicine Medicine & Public Health Mortality Mutation Next-generation sequencing Original Paper Prognosis Risk Factors Smoking Stenosis Transcatheter Aortic Valve Replacement - methods Treatment Outcome Vascular diseases
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