Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both cyclooxygenase (COX)-1 and COX-2 enzymes, leading t...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37080-e37080 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e37080 |
|---|---|
| container_issue | 4 |
| container_start_page | e37080 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 15 |
| creator | Sohail, Rohab Mathew, Midhun Patel, Khushbu K Reddy, Srija A Haider, Zaroon Naria, Mansi Habib, Ayesha Abdin, Zain U Razzaq Chaudhry, Waleed Akbar, Anum |
| description | Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both cyclooxygenase (COX)-1 and COX-2 enzymes, leading to a decrease in gastroprotective prostaglandins (PG). To minimize these adverse effects, various approaches have been explored, including selective COX-2 inhibitors, NO-NSAIDs (nitric oxide-releasing NSAIDs), and dual COX/LOX (lipoxygenase) NSAIDs. However, the effects of these gastroprotective NSAIDs on the GIT and their efficacy remains uncertain. This review aims to provide an overview of the current understanding of the effects of traditional NSAIDs and gastroprotective NSAIDs on GIT. We discuss the underlying mechanisms of GIT damage caused by NSAIDs, including mucosal injury, ulceration, and bleeding, and the potential of gastroprotective NSAIDs to mitigate these effects. We also summarize recent studies on the efficacy and safety of various gastroprotective NSAIDs and highlight the limitations and challenges of these approaches. The review concludes with recommendations for future research in this field. |
| doi_str_mv | 10.7759/cureus.37080 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10156439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2821262393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-753d7b2e9e120026c9fac1f86cd9cd73269d30dd1264f0674bee4b4fd24fb0e73</originalsourceid><addsrcrecordid>eNpdkU1LHTEUhkNpqWLddV0C3Sh0bD5mJjPdlItaK8gtVF2HTHKikZnkNslc8Rf0bzd6b8V2lcD75OGcvAi9p-RIiKb_rOcIczrignTkFdpltO2qjnb16xf3HbSf0h0hhBLBiCBv0Q4XtOFM9Lvo96m1oHPCweJl8FXKEIMzasQLn13lvB3VNKkc4gM-ifNNwgfLy8X5STrEyht8plKOYRVDLhK3BrwJcfA438I2dj5Dys4X6VVUOn_BC7xUMaqnFz9h7eD-HXpj1Zhgf3vuoetvp1fH36uLH2fnx4uLSvOa50o03IiBQQ-UEcJa3Vulqe1abXptBGdtbzgxhrK2tqQV9QBQD7U1rLYDAcH30NeNdzUPExgNPkc1ylV0k4oPMign_028u5U3YS0poU1b874YDraGGH7NZTE5uaRhHJWHMCfJOkoZbSjjBf34H3oX5lj-4ZFiZUZWfIX6tKF0DClFsM_TUCIfW5abluVTywX_8HKDZ_hvp_wPoL2law</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821262393</pqid></control><display><type>article</type><title>Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Sohail, Rohab ; Mathew, Midhun ; Patel, Khushbu K ; Reddy, Srija A ; Haider, Zaroon ; Naria, Mansi ; Habib, Ayesha ; Abdin, Zain U ; Razzaq Chaudhry, Waleed ; Akbar, Anum</creator><creatorcontrib>Sohail, Rohab ; Mathew, Midhun ; Patel, Khushbu K ; Reddy, Srija A ; Haider, Zaroon ; Naria, Mansi ; Habib, Ayesha ; Abdin, Zain U ; Razzaq Chaudhry, Waleed ; Akbar, Anum</creatorcontrib><description>Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both cyclooxygenase (COX)-1 and COX-2 enzymes, leading to a decrease in gastroprotective prostaglandins (PG). To minimize these adverse effects, various approaches have been explored, including selective COX-2 inhibitors, NO-NSAIDs (nitric oxide-releasing NSAIDs), and dual COX/LOX (lipoxygenase) NSAIDs. However, the effects of these gastroprotective NSAIDs on the GIT and their efficacy remains uncertain. This review aims to provide an overview of the current understanding of the effects of traditional NSAIDs and gastroprotective NSAIDs on GIT. We discuss the underlying mechanisms of GIT damage caused by NSAIDs, including mucosal injury, ulceration, and bleeding, and the potential of gastroprotective NSAIDs to mitigate these effects. We also summarize recent studies on the efficacy and safety of various gastroprotective NSAIDs and highlight the limitations and challenges of these approaches. The review concludes with recommendations for future research in this field.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.37080</identifier><identifier>PMID: 37153279</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Acids ; Analgesics ; Anti-inflammatory agents ; Aspirin ; Coronaviruses ; COVID-19 ; Enzymes ; Gastroenterology ; Infections ; Inflammation ; Internal Medicine ; Migraine ; Narcotics ; Nitric oxide ; Nonsteroidal anti-inflammatory drugs ; Osteoarthritis ; Pain ; Physiology ; Prescription drugs ; Rheumatoid arthritis</subject><ispartof>Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37080-e37080</ispartof><rights>Copyright © 2023, Sohail et al.</rights><rights>Copyright © 2023, Sohail et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Sohail et al. 2023 Sohail et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-753d7b2e9e120026c9fac1f86cd9cd73269d30dd1264f0674bee4b4fd24fb0e73</citedby><cites>FETCH-LOGICAL-c343t-753d7b2e9e120026c9fac1f86cd9cd73269d30dd1264f0674bee4b4fd24fb0e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156439/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156439/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37153279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sohail, Rohab</creatorcontrib><creatorcontrib>Mathew, Midhun</creatorcontrib><creatorcontrib>Patel, Khushbu K</creatorcontrib><creatorcontrib>Reddy, Srija A</creatorcontrib><creatorcontrib>Haider, Zaroon</creatorcontrib><creatorcontrib>Naria, Mansi</creatorcontrib><creatorcontrib>Habib, Ayesha</creatorcontrib><creatorcontrib>Abdin, Zain U</creatorcontrib><creatorcontrib>Razzaq Chaudhry, Waleed</creatorcontrib><creatorcontrib>Akbar, Anum</creatorcontrib><title>Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both cyclooxygenase (COX)-1 and COX-2 enzymes, leading to a decrease in gastroprotective prostaglandins (PG). To minimize these adverse effects, various approaches have been explored, including selective COX-2 inhibitors, NO-NSAIDs (nitric oxide-releasing NSAIDs), and dual COX/LOX (lipoxygenase) NSAIDs. However, the effects of these gastroprotective NSAIDs on the GIT and their efficacy remains uncertain. This review aims to provide an overview of the current understanding of the effects of traditional NSAIDs and gastroprotective NSAIDs on GIT. We discuss the underlying mechanisms of GIT damage caused by NSAIDs, including mucosal injury, ulceration, and bleeding, and the potential of gastroprotective NSAIDs to mitigate these effects. We also summarize recent studies on the efficacy and safety of various gastroprotective NSAIDs and highlight the limitations and challenges of these approaches. The review concludes with recommendations for future research in this field.</description><subject>Acids</subject><subject>Analgesics</subject><subject>Anti-inflammatory agents</subject><subject>Aspirin</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Enzymes</subject><subject>Gastroenterology</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Migraine</subject><subject>Narcotics</subject><subject>Nitric oxide</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Osteoarthritis</subject><subject>Pain</subject><subject>Physiology</subject><subject>Prescription drugs</subject><subject>Rheumatoid arthritis</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU1LHTEUhkNpqWLddV0C3Sh0bD5mJjPdlItaK8gtVF2HTHKikZnkNslc8Rf0bzd6b8V2lcD75OGcvAi9p-RIiKb_rOcIczrignTkFdpltO2qjnb16xf3HbSf0h0hhBLBiCBv0Q4XtOFM9Lvo96m1oHPCweJl8FXKEIMzasQLn13lvB3VNKkc4gM-ifNNwgfLy8X5STrEyht8plKOYRVDLhK3BrwJcfA438I2dj5Dys4X6VVUOn_BC7xUMaqnFz9h7eD-HXpj1Zhgf3vuoetvp1fH36uLH2fnx4uLSvOa50o03IiBQQ-UEcJa3Vulqe1abXptBGdtbzgxhrK2tqQV9QBQD7U1rLYDAcH30NeNdzUPExgNPkc1ylV0k4oPMign_028u5U3YS0poU1b874YDraGGH7NZTE5uaRhHJWHMCfJOkoZbSjjBf34H3oX5lj-4ZFiZUZWfIX6tKF0DClFsM_TUCIfW5abluVTywX_8HKDZ_hvp_wPoL2law</recordid><startdate>20230403</startdate><enddate>20230403</enddate><creator>Sohail, Rohab</creator><creator>Mathew, Midhun</creator><creator>Patel, Khushbu K</creator><creator>Reddy, Srija A</creator><creator>Haider, Zaroon</creator><creator>Naria, Mansi</creator><creator>Habib, Ayesha</creator><creator>Abdin, Zain U</creator><creator>Razzaq Chaudhry, Waleed</creator><creator>Akbar, Anum</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230403</creationdate><title>Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review</title><author>Sohail, Rohab ; Mathew, Midhun ; Patel, Khushbu K ; Reddy, Srija A ; Haider, Zaroon ; Naria, Mansi ; Habib, Ayesha ; Abdin, Zain U ; Razzaq Chaudhry, Waleed ; Akbar, Anum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-753d7b2e9e120026c9fac1f86cd9cd73269d30dd1264f0674bee4b4fd24fb0e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Analgesics</topic><topic>Anti-inflammatory agents</topic><topic>Aspirin</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Enzymes</topic><topic>Gastroenterology</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Migraine</topic><topic>Narcotics</topic><topic>Nitric oxide</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Osteoarthritis</topic><topic>Pain</topic><topic>Physiology</topic><topic>Prescription drugs</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohail, Rohab</creatorcontrib><creatorcontrib>Mathew, Midhun</creatorcontrib><creatorcontrib>Patel, Khushbu K</creatorcontrib><creatorcontrib>Reddy, Srija A</creatorcontrib><creatorcontrib>Haider, Zaroon</creatorcontrib><creatorcontrib>Naria, Mansi</creatorcontrib><creatorcontrib>Habib, Ayesha</creatorcontrib><creatorcontrib>Abdin, Zain U</creatorcontrib><creatorcontrib>Razzaq Chaudhry, Waleed</creatorcontrib><creatorcontrib>Akbar, Anum</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohail, Rohab</au><au>Mathew, Midhun</au><au>Patel, Khushbu K</au><au>Reddy, Srija A</au><au>Haider, Zaroon</au><au>Naria, Mansi</au><au>Habib, Ayesha</au><au>Abdin, Zain U</au><au>Razzaq Chaudhry, Waleed</au><au>Akbar, Anum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-04-03</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>e37080</spage><epage>e37080</epage><pages>e37080-e37080</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both cyclooxygenase (COX)-1 and COX-2 enzymes, leading to a decrease in gastroprotective prostaglandins (PG). To minimize these adverse effects, various approaches have been explored, including selective COX-2 inhibitors, NO-NSAIDs (nitric oxide-releasing NSAIDs), and dual COX/LOX (lipoxygenase) NSAIDs. However, the effects of these gastroprotective NSAIDs on the GIT and their efficacy remains uncertain. This review aims to provide an overview of the current understanding of the effects of traditional NSAIDs and gastroprotective NSAIDs on GIT. We discuss the underlying mechanisms of GIT damage caused by NSAIDs, including mucosal injury, ulceration, and bleeding, and the potential of gastroprotective NSAIDs to mitigate these effects. We also summarize recent studies on the efficacy and safety of various gastroprotective NSAIDs and highlight the limitations and challenges of these approaches. The review concludes with recommendations for future research in this field.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>37153279</pmid><doi>10.7759/cureus.37080</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37080-e37080 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10156439 |
| source | PubMed Central; PubMed Central Open Access |
| subjects | Acids Analgesics Anti-inflammatory agents Aspirin Coronaviruses COVID-19 Enzymes Gastroenterology Infections Inflammation Internal Medicine Migraine Narcotics Nitric oxide Nonsteroidal anti-inflammatory drugs Osteoarthritis Pain Physiology Prescription drugs Rheumatoid arthritis |
| title | Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T17%3A16%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Non-steroidal%20Anti-inflammatory%20Drugs%20(NSAIDs)%20and%20Gastroprotective%20NSAIDs%20on%20the%20Gastrointestinal%20Tract:%20A%20Narrative%20Review&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Sohail,%20Rohab&rft.date=2023-04-03&rft.volume=15&rft.issue=4&rft.spage=e37080&rft.epage=e37080&rft.pages=e37080-e37080&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.37080&rft_dat=%3Cproquest_pubme%3E2821262393%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2821262393&rft_id=info:pmid/37153279&rfr_iscdi=true |