Neural tube defect recurrence after 'partial' vitamin supplementation
A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/...
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| Veröffentlicht in: | Journal of medical genetics 1989-05, Vol.26 (5), p.326-329 |
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| container_title | Journal of medical genetics |
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| creator | Sheppard, S Nevin, N C Seller, M J Wild, J Smithells, R W Read, A P Harris, R Fielding, D W Schorah, C J |
| description | A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four previous NTDs. The observed NTD recurrence rate is similar to that observed in fully supplemented mothers. A further 14 mothers started supplements before the second missed period but after the normal time of neural tube closure. Three of their offspring had NTD. The significance of this apparently high recurrence rate is discussed. |
| doi_str_mv | 10.1136/jmg.26.5.326 |
| format | Article |
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Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four previous NTDs. The observed NTD recurrence rate is similar to that observed in fully supplemented mothers. A further 14 mothers started supplements before the second missed period but after the normal time of neural tube closure. Three of their offspring had NTD. The significance of this apparently high recurrence rate is discussed.</description><identifier>ISSN: 0022-2593</identifier><identifier>ISSN: 1468-6244</identifier><identifier>EISSN: 1468-6244</identifier><identifier>DOI: 10.1136/jmg.26.5.326</identifier><identifier>PMID: 2732994</identifier><identifier>CODEN: JMDGAE</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Ascorbic Acid - administration & dosage ; Ascorbic Acid - therapeutic use ; Biological and medical sciences ; Diseases of the nervous system ; Drug Administration Schedule ; Drug Combinations - administration & dosage ; Drug Combinations - therapeutic use ; Female ; Humans ; Medical sciences ; Neural Tube Defects - prevention & control ; Pregnancy ; Pregnancy Outcome ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Recurrence ; Vitamin B Complex - administration & dosage ; Vitamin B Complex - therapeutic use</subject><ispartof>Journal of medical genetics, 1989-05, Vol.26 (5), p.326-329</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 1989</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b538t-272cec58b98fd33b1a113a0d550e4a2bd3ec5c5abc18ac7449a4968caa4d9a5a3</citedby><cites>FETCH-LOGICAL-b538t-272cec58b98fd33b1a113a0d550e4a2bd3ec5c5abc18ac7449a4968caa4d9a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015600/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015600/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19736794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2732994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheppard, S</creatorcontrib><creatorcontrib>Nevin, N C</creatorcontrib><creatorcontrib>Seller, M J</creatorcontrib><creatorcontrib>Wild, J</creatorcontrib><creatorcontrib>Smithells, R W</creatorcontrib><creatorcontrib>Read, A P</creatorcontrib><creatorcontrib>Harris, R</creatorcontrib><creatorcontrib>Fielding, D W</creatorcontrib><creatorcontrib>Schorah, C J</creatorcontrib><title>Neural tube defect recurrence after 'partial' vitamin supplementation</title><title>Journal of medical genetics</title><addtitle>J Med Genet</addtitle><description>A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four previous NTDs. The observed NTD recurrence rate is similar to that observed in fully supplemented mothers. A further 14 mothers started supplements before the second missed period but after the normal time of neural tube closure. Three of their offspring had NTD. The significance of this apparently high recurrence rate is discussed.</description><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diseases of the nervous system</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations - administration & dosage</subject><subject>Drug Combinations - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neural Tube Defects - prevention & control</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Recurrence</subject><subject>Vitamin B Complex - administration & dosage</subject><subject>Vitamin B Complex - therapeutic use</subject><issn>0022-2593</issn><issn>1468-6244</issn><issn>1468-6244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFDEQhC0ECkvgxhVpJAR7YRY_xvb4goQ2CUFE4QKIm9Xj6Qle5rHYnij8exx2tTwOcOpDfaqu7iLkMaMrxoR6uRmuVlyt5EpwdYcsWKXqUvGquksWlHJecmnEffIgxg2lTGimjsgR14IbUy3I6SXOAfoizQ0WLXboUhHQzSHg6LCALmEollsIyUO_LK59gsGPRZy32x4HHBMkP40Pyb0O-oiP9vOYfDw7_bA-Ly_ev3m7fn1RNlLUqeSaO3SybkzdtUI0DPIBQFspKVbAm1Zk1UloHKvB6aoyUBlVO4CqNSBBHJNXO9_t3AzYurw_h7fb4AcI3-0E3v6pjP6LvZquLaNMKkqzwfO9QZi-zRiTHXx02Pcw4jRHqw3l1Ij_g0xqragQGXz6F7iZ5jDmL1imNZW6lsZk6sWOcmGKMWB3yMyovW3R5hYtV1ba3GLGn_x-5wHe15b1Z3sdooO-CzA6H395Gi2U_smVO87HhDcHHcJXq7TQ0l5-WtvP787U-cla29uYyx3fDJt_J_wBg2XBwg</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Sheppard, S</creator><creator>Nevin, N C</creator><creator>Seller, M J</creator><creator>Wild, J</creator><creator>Smithells, R W</creator><creator>Read, A P</creator><creator>Harris, R</creator><creator>Fielding, D W</creator><creator>Schorah, C J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890501</creationdate><title>Neural tube defect recurrence after 'partial' vitamin supplementation</title><author>Sheppard, S ; Nevin, N C ; Seller, M J ; Wild, J ; Smithells, R W ; Read, A P ; Harris, R ; Fielding, D W ; Schorah, C J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b538t-272cec58b98fd33b1a113a0d550e4a2bd3ec5c5abc18ac7449a4968caa4d9a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Diseases of the nervous system</topic><topic>Drug Administration Schedule</topic><topic>Drug Combinations - administration & dosage</topic><topic>Drug Combinations - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neural Tube Defects - prevention & control</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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| ispartof | Journal of medical genetics, 1989-05, Vol.26 (5), p.326-329 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Ascorbic Acid - administration & dosage Ascorbic Acid - therapeutic use Biological and medical sciences Diseases of the nervous system Drug Administration Schedule Drug Combinations - administration & dosage Drug Combinations - therapeutic use Female Humans Medical sciences Neural Tube Defects - prevention & control Pregnancy Pregnancy Outcome Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recurrence Vitamin B Complex - administration & dosage Vitamin B Complex - therapeutic use |
| title | Neural tube defect recurrence after 'partial' vitamin supplementation |
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