Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes

T-cell receptor (TCR) binding strength to peptide-MHC antigen complex influences numerous T-cell functions. However, the vast diversity of a polyclonal T-cell repertoire for even a single antigen greatly increases the complexity of studying the impact of TCR affinity on T-cell function. Here, we det...

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Veröffentlicht in:	Cancer immunology research 2023-05, Vol.11 (5), p.570-582
Hauptverfasser:	Hay, Zachary L Z, Knapp, Jennifer R, Magallon, Roman E, O'Connor, Brian P, Slansky, Jill E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism CD8-Positive T-Lymphocytes Lymphocytes, Tumor-Infiltrating Mice Mice, Transgenic Neoplasms - metabolism Peptides - metabolism Receptors, Antigen, T-Cell T-Lymphocytes Tumor Microenvironment
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