CircLASP1 silence strengthens the therapeutic effects of MK‐2206 on nasopharyngeal cancer through upregulating miR‐625

Therapeutic effects of MK‐2206 are largely limited due to the complexity of the pathogenesis of nasopharyngeal cancer (NPC). Here, we aimed to investigate whether and how circLASP1 is involved in the therapeutic effects of MK‐2206 on NPC. We showed circLASP1 was increased while miR‐625 was decreased...

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Veröffentlicht in:	Cancer science 2023-05, Vol.114 (5), p.2123-2138
Hauptverfasser:	Xu, Li‐Na, Liu, Si‐Le, Yang, Yang, Shu, Lu, Sun, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibodies Apoptosis Autophagy Cancer Cell Line, Tumor Cell Proliferation Cells CircLASP1 Flow cytometry Gene Expression Regulation, Neoplastic Humans Hybridization Laboratory animals MicroRNAs MicroRNAs - genetics MicroRNAs - pharmacology miR‐625 MK‐2206 nasopharyngeal cancer Nasopharyngeal Carcinoma - drug therapy Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Original ORIGINAL ARTICLES Pathogenesis Proteins Proto-Oncogene Proteins c-akt - metabolism Roles TOR protein TOR Serine-Threonine Kinases - metabolism Tumor suppressor genes Tumorigenesis Tumors Variance analysis
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