Histone demethylase KDM5B licenses macrophage-mediated inflammatory responses by repressing Nfkbia transcription

Macrophages play a critical role in the immune homeostasis and host defense against invading pathogens. However, uncontrolled activation of inflammatory macrophages leads to tissue injury and even fuels autoimmunity. Hence the molecular mechanisms underlying macrophage activation need to be further...

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Veröffentlicht in:	Cell death and differentiation 2023-05, Vol.30 (5), p.1279-1292
Hauptverfasser:	Zhang, Yunkai, Gao, Ying, Jiang, Yuyu, Ding, Yingying, Chen, Huiying, Xiang, Yan, Zhan, Zhenzhen, Liu, Xingguang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 14/1 42/109 42/89 631/250/256 631/337/176 64/60 692/420/2780 692/699/1670 82/51 96/95 Animals Apoptosis Arthritis Autoimmune diseases Autoimmunity Biochemistry Biomedical and Life Sciences Cancer Cell activation Cell Biology Cell Cycle Analysis Cell Differentiation Chromatin Collagen Cytokines DNA-Binding Proteins - metabolism Endotoxin shock Epigenetics Gene expression Gene Expression Regulation Genomes Gram-positive bacteria Histone Demethylases - genetics Histone Demethylases - metabolism Histones Homeostasis Hospitals Inflammatory diseases Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kinases Laboratories Life Sciences Ligands Macrophages Mice Molecular modelling NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism NF-κB protein Pathogenesis Pathogens Proteins Rheumatology Stem Cells Therapeutic targets
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