Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence

Accumulation of senescent cells with age is an important driver of aging and age-related diseases. However, the mechanisms and signaling pathways that regulate senescence remain elusive. In this report, we performed post-genome-wide association studies (GWAS) functional studies on the CDKN2A/B locus...

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Veröffentlicht in:	Nature aging 2022-02, Vol.2 (2), p.140-154
Hauptverfasser:	Jiang, Danli, Sun, Wei, Wu, Ting, Zou, Meijuan, Vasamsetti, Sathish Babu, Zhang, Xiaoyu, Zhao, Yihan, Phillippi, Julie A., Sawalha, Amr H., Tavakoli, Sina, Dutta, Partha, Florentin, Jonathan, Chan, Stephen Y., Tollison, Tammy S., Di Wu, Cui, Jing, Huntress, Ian, Peng, Xinxia, Finkel, Toren, Li, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Senescence Transcription factors
Online-Zugang:	Volltext
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