Shared grey matter correlates of reading and attention
•Reading and attention difficulties occur together more often than chance.•The neural bases of this comorbidity are not well understood.•We investigated shared neural correlates of reading and attention in healthy youth.•Grey matter correlates overlapped in the precuneus and caudate nucleus.•These a...
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| Veröffentlicht in: | Brain and language 2023-02, Vol.237, p.105230-105230, Article 105230 |
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| container_title | Brain and language |
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| creator | Lee, Marissa M. Drury, Brianne C. McGrath, Lauren M. Stoodley, Catherine J. |
| description | •Reading and attention difficulties occur together more often than chance.•The neural bases of this comorbidity are not well understood.•We investigated shared neural correlates of reading and attention in healthy youth.•Grey matter correlates overlapped in the precuneus and caudate nucleus.•These are potential regions of interest for comorbid reading and attention problems.
Disorders of reading (developmental dyslexia) and attention (ADHD) have a high rate of comorbidity (25–40%), yet little is known about the neural underpinnings of this phenomenon. The current study investigated the shared and unique neural correlates of reading and attention in 330 typically developing children ages 8–18 from the Philadelphia Neurodevelopmental Cohort. Multiple regression analyses were used to identify regions of the brain where grey matter (GM) volume was associated with reading or attention scores (p |
| doi_str_mv | 10.1016/j.bandl.2023.105230 |
| format | Article |
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Disorders of reading (developmental dyslexia) and attention (ADHD) have a high rate of comorbidity (25–40%), yet little is known about the neural underpinnings of this phenomenon. The current study investigated the shared and unique neural correlates of reading and attention in 330 typically developing children ages 8–18 from the Philadelphia Neurodevelopmental Cohort. Multiple regression analyses were used to identify regions of the brain where grey matter (GM) volume was associated with reading or attention scores (p < 0.001, cluster FDR p < 0.05). Better attention scores correlated with increased GM in the precuneus and higher reading scores were associated with greater thalamic GM. An exploratory conjunction analysis (p < 0.05, k > 239) found that GM in the caudate and precuneus correlated with both reading and attention scores. These results are consistent with a recent meta-analysis which identified GM reductions in the caudate in both dyslexia and ADHD and reveal potential shared neural correlates of reading and attention.</description><identifier>ISSN: 0093-934X</identifier><identifier>EISSN: 1090-2155</identifier><identifier>DOI: 10.1016/j.bandl.2023.105230</identifier><identifier>PMID: 36731345</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adolescent ; Attention Deficit Disorder with Hyperactivity - diagnostic imaging ; Attention-deficit/hyperactivity disorder (ADHD) ; Behavioral attention ; Caudate ; Child ; Developmental dyslexia ; Dyslexia - diagnostic imaging ; Gray Matter - diagnostic imaging ; Humans ; Magnetic Resonance Imaging - methods ; Precuneus ; Reading ; Voxel-based morphometry</subject><ispartof>Brain and language, 2023-02, Vol.237, p.105230-105230, Article 105230</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-ba7c6a2d12b638fae314cacb4b66ffa3cce8d542838e8ff93c6be58deec567863</citedby><cites>FETCH-LOGICAL-c460t-ba7c6a2d12b638fae314cacb4b66ffa3cce8d542838e8ff93c6be58deec567863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093934X23000093$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36731345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Marissa M.</creatorcontrib><creatorcontrib>Drury, Brianne C.</creatorcontrib><creatorcontrib>McGrath, Lauren M.</creatorcontrib><creatorcontrib>Stoodley, Catherine J.</creatorcontrib><title>Shared grey matter correlates of reading and attention</title><title>Brain and language</title><addtitle>Brain Lang</addtitle><description>•Reading and attention difficulties occur together more often than chance.•The neural bases of this comorbidity are not well understood.•We investigated shared neural correlates of reading and attention in healthy youth.•Grey matter correlates overlapped in the precuneus and caudate nucleus.•These are potential regions of interest for comorbid reading and attention problems.
Disorders of reading (developmental dyslexia) and attention (ADHD) have a high rate of comorbidity (25–40%), yet little is known about the neural underpinnings of this phenomenon. The current study investigated the shared and unique neural correlates of reading and attention in 330 typically developing children ages 8–18 from the Philadelphia Neurodevelopmental Cohort. Multiple regression analyses were used to identify regions of the brain where grey matter (GM) volume was associated with reading or attention scores (p < 0.001, cluster FDR p < 0.05). Better attention scores correlated with increased GM in the precuneus and higher reading scores were associated with greater thalamic GM. An exploratory conjunction analysis (p < 0.05, k > 239) found that GM in the caudate and precuneus correlated with both reading and attention scores. These results are consistent with a recent meta-analysis which identified GM reductions in the caudate in both dyslexia and ADHD and reveal potential shared neural correlates of reading and attention.</description><subject>Adolescent</subject><subject>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</subject><subject>Attention-deficit/hyperactivity disorder (ADHD)</subject><subject>Behavioral attention</subject><subject>Caudate</subject><subject>Child</subject><subject>Developmental dyslexia</subject><subject>Dyslexia - diagnostic imaging</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Precuneus</subject><subject>Reading</subject><subject>Voxel-based morphometry</subject><issn>0093-934X</issn><issn>1090-2155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWj9-gSB79LI1yWzS9CAixS8QPKjgLWST2TZlu9FkK_jvTW0VvXgKZN55n-Eh5JjRIaNMns2HtelcO-SUQ_4RHOgWGTA6piVnQmyTAaVjKMdQveyR_ZTmlDJWKbZL9kCOgEElBkQ-zkxEV0wjfhQL0_cYCxtixNb0mIrQFBGN8920yKxiNe96H7pDstOYNuHR5j0gz9dXT5Pb8v7h5m5yeV_aStK-rM3ISsMd47UE1RgEVllj66qWsmkMWIvKiYorUKiaZgxW1iiUQ7RCjpSEA3Kx7n1d1gt0NtOjafVr9AsTP3QwXv-ddH6mp-FdZ0MChILccLppiOFtianXC58stq3pMCyT5qOsgksJKxisozaGlCI2PxxGV4VSz_WXcr1SrtfK89bJ7xN_dr4d58D5OoBZ1LvHqJP12Fl0PqLttQv-X8AnoWWUmQ</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Lee, Marissa M.</creator><creator>Drury, Brianne C.</creator><creator>McGrath, Lauren M.</creator><creator>Stoodley, Catherine J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202302</creationdate><title>Shared grey matter correlates of reading and attention</title><author>Lee, Marissa M. ; Drury, Brianne C. ; McGrath, Lauren M. ; Stoodley, Catherine J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-ba7c6a2d12b638fae314cacb4b66ffa3cce8d542838e8ff93c6be58deec567863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</topic><topic>Attention-deficit/hyperactivity disorder (ADHD)</topic><topic>Behavioral attention</topic><topic>Caudate</topic><topic>Child</topic><topic>Developmental dyslexia</topic><topic>Dyslexia - diagnostic imaging</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Precuneus</topic><topic>Reading</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Marissa M.</creatorcontrib><creatorcontrib>Drury, Brianne C.</creatorcontrib><creatorcontrib>McGrath, Lauren M.</creatorcontrib><creatorcontrib>Stoodley, Catherine J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain and language</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Marissa M.</au><au>Drury, Brianne C.</au><au>McGrath, Lauren M.</au><au>Stoodley, Catherine J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared grey matter correlates of reading and attention</atitle><jtitle>Brain and language</jtitle><addtitle>Brain Lang</addtitle><date>2023-02</date><risdate>2023</risdate><volume>237</volume><spage>105230</spage><epage>105230</epage><pages>105230-105230</pages><artnum>105230</artnum><issn>0093-934X</issn><eissn>1090-2155</eissn><abstract>•Reading and attention difficulties occur together more often than chance.•The neural bases of this comorbidity are not well understood.•We investigated shared neural correlates of reading and attention in healthy youth.•Grey matter correlates overlapped in the precuneus and caudate nucleus.•These are potential regions of interest for comorbid reading and attention problems.
Disorders of reading (developmental dyslexia) and attention (ADHD) have a high rate of comorbidity (25–40%), yet little is known about the neural underpinnings of this phenomenon. The current study investigated the shared and unique neural correlates of reading and attention in 330 typically developing children ages 8–18 from the Philadelphia Neurodevelopmental Cohort. Multiple regression analyses were used to identify regions of the brain where grey matter (GM) volume was associated with reading or attention scores (p < 0.001, cluster FDR p < 0.05). Better attention scores correlated with increased GM in the precuneus and higher reading scores were associated with greater thalamic GM. An exploratory conjunction analysis (p < 0.05, k > 239) found that GM in the caudate and precuneus correlated with both reading and attention scores. These results are consistent with a recent meta-analysis which identified GM reductions in the caudate in both dyslexia and ADHD and reveal potential shared neural correlates of reading and attention.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>36731345</pmid><doi>10.1016/j.bandl.2023.105230</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain and language, 2023-02, Vol.237, p.105230-105230, Article 105230 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention-deficit/hyperactivity disorder (ADHD) Behavioral attention Caudate Child Developmental dyslexia Dyslexia - diagnostic imaging Gray Matter - diagnostic imaging Humans Magnetic Resonance Imaging - methods Precuneus Reading Voxel-based morphometry |
| title | Shared grey matter correlates of reading and attention |
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