Elucidation of the genetic causes of bicuspid aortic valve disease

Abstract Aims The present study aims to characterize the genetic risk architecture of bicuspid aortic valve (BAV) disease, the most common congenital heart defect. Methods and results We carried out a genome-wide association study (GWAS) including 2236 BAV patients and 11 604 controls. This led to t...

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Veröffentlicht in:	Cardiovascular research 2023-05, Vol.119 (3), p.857-866
Hauptverfasser:	Gehlen, Jan, Stundl, Anja, Debiec, Radoslaw, Fontana, Federica, Krane, Markus, Sharipova, Dinara, Nelson, Christopher P, Al-Kassou, Baravan, Giel, Ann-Sophie, Sinning, Jan-Malte, Bruenger, Christopher M H, Zelck, Carolin F, Koebbe, Laura L, Braund, Peter S, Webb, Thomas R, Hetherington, Simon, Ensminger, Stephan, Fujita, Buntaro, Mohamed, Salah A, Shrestha, Malakh, Krueger, Heike, Siepe, Matthias, Kari, Fabian Alexander, Nordbeck, Peter, Buravezky, Larissa, Kelm, Malte, Veulemans, Verena, Adam, Matti, Baldus, Stephan, Laugwitz, Karl-Ludwig, Haas, Yannick, Karck, Matthias, Mehlhorn, Uwe, Conzelmann, Lars Oliver, Breitenbach, Ingo, Lebherz, Corinna, Urbanski, Paul, Kim, Won-Keun, Kandels, Joscha, Ellinghaus, David, Nowak-Goettl, Ulrike, Hoffmann, Per, Wirth, Felix, Doppler, Stefanie, Lahm, Harald, Dreßen, Martina, von Scheidt, Moritz, Knoll, Katharina, Kessler, Thorsten, Hengstenberg, Christian, Schunkert, Heribert, Nickenig, Georg, Nöthen, Markus M, Bolger, Aidan P, Abdelilah-Seyfried, Salim, Samani, Nilesh J, Erdmann, Jeanette, Trenkwalder, Teresa, Schumacher, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Valve - pathology Bicuspid Aortic Valve Disease - metabolism Bicuspid Aortic Valve Disease - pathology Editor's Choice Endothelial Cells - metabolism Genome-Wide Association Study Heart Valve Diseases - pathology Humans Original Zebrafish - genetics
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