Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

Amplification of HER2 can drive the proliferation of cancer cells, and several inhibitors of HER2 have been successfully developed. Recent advances in next-generation sequencing now reveal that HER2 is subject to mutation, with over 2,000 unique variants observed in human cancers. Several examples o...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2023-05, Vol.83 (9), p.1531-1542
Hauptverfasser:	Ishiyama, Noboru, O'Connor, Matthew, Salomatov, Andrei, Romashko, Darlene, Thakur, Shalabh, Mentes, Ahmet, Hopkins, Julia F, Frampton, Garrett M, Albacker, Lee A, Kohlmann, Anna, Roberts, Christopher, Buck, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Allosteric Regulation Computational Cancer Biology and Technology Humans Mutation Neoplasms - genetics Protein Kinase Inhibitors - pharmacology Quinazolines - pharmacology Receptor, ErbB-2 - metabolism
Online-Zugang:	Volltext
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