SPECT findings in Parkinson's disease associated with dementia
Dementia in Parkinson's disease is thought to be attributable not only to subcortical lesions but also to cortical alterations, especially frontal lobe dysfunction. To evaluate cortical function, the regional cerebral blood flow (rCBF) was estimated of 13 demented and 13 non-demented age matche...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1992-10, Vol.55 (10), p.960-963 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Sawada, H Udaka, F Kameyama, M Seriu, N Nishinaka, K Shindou, K Kodama, M Nishitani, N Okumiya, K |
| description | Dementia in Parkinson's disease is thought to be attributable not only to subcortical lesions but also to cortical alterations, especially frontal lobe dysfunction. To evaluate cortical function, the regional cerebral blood flow (rCBF) was estimated of 13 demented and 13 non-demented age matched patients with Parkinson's disease compared with that of 10 age matched controls using I-123 iodoamphetamine single photon emission tomography (IMP-SPECT). The rCBF of the nondemented Parkinson's patients showed no significant differences from that of the control subjects. In the demented patients, the bilateral frontal and parietal and left temporal regional blood flow was significantly less than in the controls. Four demented patients showed isolated frontal hypoperfusion, 8 showed fronto-parietal hypoperfusion, and 1 showed isolated parietal hypoperfusion. Frontal hypoperfusion was therefore present in 12 of the 13 demented patients, and this finding agrees with the frontal lobe dysfunction hypothesis. Parietal rCBF had a significant positive correlation with cortical functions such as calculation and language ability in the MMSE scores. The parietal and temporal reduction in rCBF probably reflects the presence of Alzheimer pathology, cortical Lewy body disease, or both. |
| doi_str_mv | 10.1136/jnnp.55.10.960 |
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To evaluate cortical function, the regional cerebral blood flow (rCBF) was estimated of 13 demented and 13 non-demented age matched patients with Parkinson's disease compared with that of 10 age matched controls using I-123 iodoamphetamine single photon emission tomography (IMP-SPECT). The rCBF of the nondemented Parkinson's patients showed no significant differences from that of the control subjects. In the demented patients, the bilateral frontal and parietal and left temporal regional blood flow was significantly less than in the controls. Four demented patients showed isolated frontal hypoperfusion, 8 showed fronto-parietal hypoperfusion, and 1 showed isolated parietal hypoperfusion. Frontal hypoperfusion was therefore present in 12 of the 13 demented patients, and this finding agrees with the frontal lobe dysfunction hypothesis. Parietal rCBF had a significant positive correlation with cortical functions such as calculation and language ability in the MMSE scores. The parietal and temporal reduction in rCBF probably reflects the presence of Alzheimer pathology, cortical Lewy body disease, or both.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.55.10.960</identifier><identifier>PMID: 1431961</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Biological and medical sciences ; Brain - blood supply ; Brain - diagnostic imaging ; Brain Ischemia - diagnostic imaging ; Brain Mapping ; Cerebral Cortex - blood supply ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - diagnostic imaging ; Female ; Humans ; Male ; Medical sciences ; Mental Status Schedule ; Neurology ; Parkinson Disease - diagnostic imaging ; Regional Blood Flow - physiology ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1992-10, Vol.55 (10), p.960-963</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Oct 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b514t-337576d226c9191cc7f2651958bce1d5752994c66f82fab7b8489f15ebaba3633</citedby><cites>FETCH-LOGICAL-b514t-337576d226c9191cc7f2651958bce1d5752994c66f82fab7b8489f15ebaba3633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015200/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015200/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4390142$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1431961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawada, H</creatorcontrib><creatorcontrib>Udaka, F</creatorcontrib><creatorcontrib>Kameyama, M</creatorcontrib><creatorcontrib>Seriu, N</creatorcontrib><creatorcontrib>Nishinaka, K</creatorcontrib><creatorcontrib>Shindou, K</creatorcontrib><creatorcontrib>Kodama, M</creatorcontrib><creatorcontrib>Nishitani, N</creatorcontrib><creatorcontrib>Okumiya, K</creatorcontrib><title>SPECT findings in Parkinson's disease associated with dementia</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Dementia in Parkinson's disease is thought to be attributable not only to subcortical lesions but also to cortical alterations, especially frontal lobe dysfunction. To evaluate cortical function, the regional cerebral blood flow (rCBF) was estimated of 13 demented and 13 non-demented age matched patients with Parkinson's disease compared with that of 10 age matched controls using I-123 iodoamphetamine single photon emission tomography (IMP-SPECT). The rCBF of the nondemented Parkinson's patients showed no significant differences from that of the control subjects. In the demented patients, the bilateral frontal and parietal and left temporal regional blood flow was significantly less than in the controls. Four demented patients showed isolated frontal hypoperfusion, 8 showed fronto-parietal hypoperfusion, and 1 showed isolated parietal hypoperfusion. Frontal hypoperfusion was therefore present in 12 of the 13 demented patients, and this finding agrees with the frontal lobe dysfunction hypothesis. Parietal rCBF had a significant positive correlation with cortical functions such as calculation and language ability in the MMSE scores. The parietal and temporal reduction in rCBF probably reflects the presence of Alzheimer pathology, cortical Lewy body disease, or both.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - blood supply</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Dementia - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Status Schedule</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Regional Blood Flow - physiology</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1v1DAQxS0EKtvClRtSJFARhywef8aXStWqFKSyVKIUbpbjOK2XxFnsbKH_PV5ltXxc8MUavZ9n3vgh9AzwHICKN6sQ1nPO57lWAj9AM2CiKinFXx-iGcaElBRz_BgdprTC21OpA3QAjIISMEMnny7PFldF60Pjw00qfCguTfzmQxrCq1Q0PjmTXGFSGqw3o2uKH368LRrXuzB68wQ9ak2X3NPdfYQ-vz27WrwrLz6ev1-cXpQ1BzZmO5JL0RAirAIF1sqWCA6KV7V10HDJiVLMCtFWpDW1rCtWqRa4q01tqKD0CJ1MfdebuneNzcOj6fQ6-t7Eez0Yr_9Wgr_VN8OdBgycYJwbHO8axOH7xqVR9z5Z13UmuGGTtKQUcB6UwRf_gKthE0NeToOUFDNgwDM1nygbh5Sia_dWAOttLnqbi-Z8W-dc8oPnfy7wG5-CyPrLnW6SNV0bTbA-7TFGFQZGMlZOmE-j-7mXc2JayPzJenm90PTLkvIPeKmvM_964ut-9T-LvwA15bFS</recordid><startdate>19921001</startdate><enddate>19921001</enddate><creator>Sawada, H</creator><creator>Udaka, F</creator><creator>Kameyama, M</creator><creator>Seriu, N</creator><creator>Nishinaka, K</creator><creator>Shindou, K</creator><creator>Kodama, M</creator><creator>Nishitani, N</creator><creator>Okumiya, K</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19921001</creationdate><title>SPECT findings in Parkinson's disease associated with dementia</title><author>Sawada, H ; Udaka, F ; Kameyama, M ; Seriu, N ; Nishinaka, K ; Shindou, K ; Kodama, M ; Nishitani, N ; Okumiya, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b514t-337576d226c9191cc7f2651958bce1d5752994c66f82fab7b8489f15ebaba3633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - blood supply</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Dementia - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Status Schedule</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Regional Blood Flow - physiology</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawada, H</creatorcontrib><creatorcontrib>Udaka, F</creatorcontrib><creatorcontrib>Kameyama, M</creatorcontrib><creatorcontrib>Seriu, N</creatorcontrib><creatorcontrib>Nishinaka, K</creatorcontrib><creatorcontrib>Shindou, K</creatorcontrib><creatorcontrib>Kodama, M</creatorcontrib><creatorcontrib>Nishitani, N</creatorcontrib><creatorcontrib>Okumiya, K</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawada, H</au><au>Udaka, F</au><au>Kameyama, M</au><au>Seriu, N</au><au>Nishinaka, K</au><au>Shindou, K</au><au>Kodama, M</au><au>Nishitani, N</au><au>Okumiya, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SPECT findings in Parkinson's disease associated with dementia</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1992-10-01</date><risdate>1992</risdate><volume>55</volume><issue>10</issue><spage>960</spage><epage>963</epage><pages>960-963</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Dementia in Parkinson's disease is thought to be attributable not only to subcortical lesions but also to cortical alterations, especially frontal lobe dysfunction. To evaluate cortical function, the regional cerebral blood flow (rCBF) was estimated of 13 demented and 13 non-demented age matched patients with Parkinson's disease compared with that of 10 age matched controls using I-123 iodoamphetamine single photon emission tomography (IMP-SPECT). The rCBF of the nondemented Parkinson's patients showed no significant differences from that of the control subjects. In the demented patients, the bilateral frontal and parietal and left temporal regional blood flow was significantly less than in the controls. Four demented patients showed isolated frontal hypoperfusion, 8 showed fronto-parietal hypoperfusion, and 1 showed isolated parietal hypoperfusion. Frontal hypoperfusion was therefore present in 12 of the 13 demented patients, and this finding agrees with the frontal lobe dysfunction hypothesis. Parietal rCBF had a significant positive correlation with cortical functions such as calculation and language ability in the MMSE scores. The parietal and temporal reduction in rCBF probably reflects the presence of Alzheimer pathology, cortical Lewy body disease, or both.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>1431961</pmid><doi>10.1136/jnnp.55.10.960</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 1992-10, Vol.55 (10), p.960-963 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Brain - blood supply Brain - diagnostic imaging Brain Ischemia - diagnostic imaging Brain Mapping Cerebral Cortex - blood supply Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - diagnostic imaging Female Humans Male Medical sciences Mental Status Schedule Neurology Parkinson Disease - diagnostic imaging Regional Blood Flow - physiology Tomography, Emission-Computed, Single-Photon |
| title | SPECT findings in Parkinson's disease associated with dementia |
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