Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs

Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there is a paucity of tools for deciphering the relative contributions of cfDNA cleavage patterns related to underlying fragmentation factors. In...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-04, Vol.120 (17), p.e2220982120-e2220982120
Hauptverfasser:	Zhou, Ze, Ma, Mary-Jane L, Chan, Rebecca W Y, Lam, W K Jacky, Peng, Wenlei, Gai, Wanxia, Hu, Xi, Ding, Spencer C, Ji, Lu, Zhou, Qing, Cheung, Peter P H, Yu, Stephanie C Y, Teoh, Jeremy Y C, Szeto, Cheuk-Chun, Wong, John, Wong, Vincent W S, Wong, Grace L H, Chan, Stephen L, Hui, Edwin P, Ma, Brigette B Y, Chan, Anthony T C, Chiu, Rossa W K, Chan, K C Allen, Lo, Y M Dennis, Jiang, Peiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animal models Animals Autoimmune diseases Biological Sciences Cancer Cell-Free Nucleic Acids - genetics Chemoradiotherapy Chronic conditions Cleavage Deoxyribonuclease Deoxyribonucleases - genetics Deoxyribonucleic acid DNA DNA Fragmentation Endodeoxyribonucleases - genetics Endonucleases - genetics Fragmentation Hepatocellular carcinoma Humans Mice Mice, Knockout Nasopharyngeal carcinoma Nuclease Oxidative stress Systemic lupus erythematosus
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