Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class

Evidence accumulated over the past decade suggests that p21-activated kinase 1 (PAK1) is a critical cardiac-protective signalling molecule. The present article provides an updated review of recent findings regarding the role of PAK1 in maintaining normal cardiac electrophysiological function through...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2023-06, Vol.378 (1879), p.20220285-20220285
Hauptverfasser:	He, Yu, Grassam-Rowe, Alexander, Lei, Ming, Bae, James S H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Arrhythmia Agents Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinases - metabolism Heart - physiology p21-Activated Kinases - metabolism Part V: Cardiac Remodeling and Excitable Properties Phosphorylation Review Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
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