Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis

Background: Rare genetic variants are emerging as important contributors to the heritability of multiple sclerosis (MS). Whether rare variants also contribute to pediatric-onset multiple sclerosis (POMS) is unknown. Objective: To test whether genes harboring rare variants associated with adult-onset...

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Veröffentlicht in:	Multiple sclerosis 2023-04, Vol.29 (4-5), p.505-511
Hauptverfasser:	Horton, Mary K, Shim, Joan E, Wallace, Amelia, Graves, Jennifer S, Aaen, Gregory, Greenberg, Benjamin, Mar, Soe, Wheeler, Yolanda, Weinstock-Guttman, Bianca, Waldman, Amy, Schreiner, Teri, Rodriguez, Moses, Tillema, Jan-Mendelt, Chitnis, Tanuja, Krupp, Lauren, Casper, T Charles, Rensel, Mary, Hart, Janace, Quach, Hong L, Quach, Diana L, Schaefer, Catherine, Waubant, Emmanuelle, Barcellos, Lisa F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Child Drb1 protein Genes Genetic diversity Genetic Predisposition to Disease Genotype Genotypes Heritability Histocompatibility antigen HLA HLA-DRB1 Chains - genetics Humans Major histocompatibility complex Multiple sclerosis Multiple Sclerosis - genetics Pediatrics
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