Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice

Duplications of the Xq28 region are a common cause of X‐linked intellectual disability (XLID). The RAB39B gene locates in Xq28 and has been implicated in disease pathogenesis. However, whether increased dosage of RAB39B leads to cognitive impairment and synaptic dysfunction remains elusive. Herein,...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2023-05, Vol.27 (9), p.1214-1226
Hauptverfasser:	Wang, Zijie, Niu, Mengxi, Zheng, Naizhen, Meng, Jian, Jiang, Yiru, Yang, Dingting, Yao, Peijie, Yao, Tingting, Luo, Hong, Xu, Huaxi, Ge, Yunlong, Zhang, Yun‐wu, Zhang, Xian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibodies Autism Autistic Disorder - genetics Autophagy Brain Cognitive ability Dendritic branching Female Genes Grooming Intellectual disabilities Intellectual Disability - genetics Intellectual Disability - metabolism Laboratory animals Memory Mice Molecular modelling mouse behaviours Mutation Neonates neuronal morphology Neurons Neurons - metabolism Original Proteins rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism RAB39B Short term memory Social behavior Sucrose Synaptic Transmission X chromosomes X‐linked intellectual disability
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