Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population
Background The number of hypothyroidism patients undergoing total knee replacement (TKA) in India is increasing. It is assumed that patients with hypothyroidism are more prone to complications following surgery. The aim of this study is to evaluate the impact of hypothyroidism on the complications f...
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| Veröffentlicht in: | Indian journal of orthopaedics 2023-05, Vol.57 (5), p.673-678 |
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| container_title | Indian journal of orthopaedics |
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| creator | Ratnakar, V. Pawar, Sawankumar Dwivedi, Ashutosh Masilamani, A. B. Suhas Karumuri, Kishore Reddy, AVGurava |
| description | Background
The number of hypothyroidism patients undergoing total knee replacement (TKA) in India is increasing. It is assumed that patients with hypothyroidism are more prone to complications following surgery. The aim of this study is to evaluate the impact of hypothyroidism on the complications following TKA.
Methods
This is a case–control analysis of patients who underwent primary total knee replacement in our hospital from 2017 to 2019. A total of 600 patients were included in the study, of which 300 patients were with hypothyroidism. We compared with a matched cohort of another 300 patients without hypothyroidism as control group.
Results
A total of 600 patients were analyzed (Hypothyroid group
n
= 300, Control group
n
= 300). The medical complications were found to be 6.2% in the hypothyroid group compared to 4% in control group (
p
= 1.66, odds ratio 0.61). Surgical complications in the hypothyroid group were 3% compared to 0.6% in control group (
p
= 4.53, odds ratio = 0.21), overall complication rates were not significant statistically when compared between hypothyroid and control group (
p
= 5.01, odds ratio 0.47). Subgroup analysis of complications of hypothyroid patients with euthyroid status versus uncontrolled hypothyroidism was done and we found no statistical difference in complications.
Conclusion
The conclusion can be that the rate of hospital stay, surgical site infections and complications were higher in hypothyroid group when compared with control group though statistically not significant. |
| doi_str_mv | 10.1007/s43465-023-00841-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10147847</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2808586728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-e68be818457ac6e0241d300ffcdc3f4ea55bad0dc11d146a96c1bad98b831ce83</originalsourceid><addsrcrecordid>eNp9kbtuFDEUhi0EIpuEF6BAU9JM8PF9KhStchORoEiKVJbX9mwczdiDPYO0b483GyJoqGz5v5wjfwh9BHwGGMsvhVEmeIsJbTFWDFrxBq2g61RLJZFv0Qpj6FrOgB6h41KeMOZEEvEeHVEJRHEhV-jhou-9nZvUN9e7Kc2Pu5yCC2VsUmzWaZyGYM0cUixNiM2PevVxLs19dD5vU4jb5u7b-V66iS6Y6kjTMjwHTtG73gzFf3g5T9D95cXd-rq9_X51sz6_bS3lbG69UBuvQDEujRUeEwaOYtz31lnaM2843xiHnQVwwITphIX60KmNomC9oifo66F3Wjajd7bul82gpxxGk3c6maD_VWJ41Nv0SwMGJhWTteHzS0NOPxdfZj2GYv0wmOjTUjRRWHElJNkPIwerzamU7PvXOYD1Hoo-QNEVin6GokUNffp7w9fIHwrVQA-GUqW49Vk_pSXH-mv_q_0NT5SaEA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2808586728</pqid></control><display><type>article</type><title>Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ratnakar, V. ; Pawar, Sawankumar ; Dwivedi, Ashutosh ; Masilamani, A. B. Suhas ; Karumuri, Kishore ; Reddy, AVGurava</creator><creatorcontrib>Ratnakar, V. ; Pawar, Sawankumar ; Dwivedi, Ashutosh ; Masilamani, A. B. Suhas ; Karumuri, Kishore ; Reddy, AVGurava</creatorcontrib><description>Background
The number of hypothyroidism patients undergoing total knee replacement (TKA) in India is increasing. It is assumed that patients with hypothyroidism are more prone to complications following surgery. The aim of this study is to evaluate the impact of hypothyroidism on the complications following TKA.
Methods
This is a case–control analysis of patients who underwent primary total knee replacement in our hospital from 2017 to 2019. A total of 600 patients were included in the study, of which 300 patients were with hypothyroidism. We compared with a matched cohort of another 300 patients without hypothyroidism as control group.
Results
A total of 600 patients were analyzed (Hypothyroid group
n
= 300, Control group
n
= 300). The medical complications were found to be 6.2% in the hypothyroid group compared to 4% in control group (
p
= 1.66, odds ratio 0.61). Surgical complications in the hypothyroid group were 3% compared to 0.6% in control group (
p
= 4.53, odds ratio = 0.21), overall complication rates were not significant statistically when compared between hypothyroid and control group (
p
= 5.01, odds ratio 0.47). Subgroup analysis of complications of hypothyroid patients with euthyroid status versus uncontrolled hypothyroidism was done and we found no statistical difference in complications.
Conclusion
The conclusion can be that the rate of hospital stay, surgical site infections and complications were higher in hypothyroid group when compared with control group though statistically not significant.</description><identifier>ISSN: 0019-5413</identifier><identifier>EISSN: 1998-3727</identifier><identifier>DOI: 10.1007/s43465-023-00841-6</identifier><identifier>PMID: 37128567</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Conservative Orthopedics ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Orthopedics ; Surgical Orthopedics</subject><ispartof>Indian journal of orthopaedics, 2023-05, Vol.57 (5), p.673-678</ispartof><rights>Indian Orthopaedics Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>Indian Orthopaedics Association 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-e68be818457ac6e0241d300ffcdc3f4ea55bad0dc11d146a96c1bad98b831ce83</cites><orcidid>0000-0001-6209-7168</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147847/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147847/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37128567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ratnakar, V.</creatorcontrib><creatorcontrib>Pawar, Sawankumar</creatorcontrib><creatorcontrib>Dwivedi, Ashutosh</creatorcontrib><creatorcontrib>Masilamani, A. B. Suhas</creatorcontrib><creatorcontrib>Karumuri, Kishore</creatorcontrib><creatorcontrib>Reddy, AVGurava</creatorcontrib><title>Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population</title><title>Indian journal of orthopaedics</title><addtitle>JOIO</addtitle><addtitle>Indian J Orthop</addtitle><description>Background
The number of hypothyroidism patients undergoing total knee replacement (TKA) in India is increasing. It is assumed that patients with hypothyroidism are more prone to complications following surgery. The aim of this study is to evaluate the impact of hypothyroidism on the complications following TKA.
Methods
This is a case–control analysis of patients who underwent primary total knee replacement in our hospital from 2017 to 2019. A total of 600 patients were included in the study, of which 300 patients were with hypothyroidism. We compared with a matched cohort of another 300 patients without hypothyroidism as control group.
Results
A total of 600 patients were analyzed (Hypothyroid group
n
= 300, Control group
n
= 300). The medical complications were found to be 6.2% in the hypothyroid group compared to 4% in control group (
p
= 1.66, odds ratio 0.61). Surgical complications in the hypothyroid group were 3% compared to 0.6% in control group (
p
= 4.53, odds ratio = 0.21), overall complication rates were not significant statistically when compared between hypothyroid and control group (
p
= 5.01, odds ratio 0.47). Subgroup analysis of complications of hypothyroid patients with euthyroid status versus uncontrolled hypothyroidism was done and we found no statistical difference in complications.
Conclusion
The conclusion can be that the rate of hospital stay, surgical site infections and complications were higher in hypothyroid group when compared with control group though statistically not significant.</description><subject>Conservative Orthopedics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Surgical Orthopedics</subject><issn>0019-5413</issn><issn>1998-3727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kbtuFDEUhi0EIpuEF6BAU9JM8PF9KhStchORoEiKVJbX9mwczdiDPYO0b483GyJoqGz5v5wjfwh9BHwGGMsvhVEmeIsJbTFWDFrxBq2g61RLJZFv0Qpj6FrOgB6h41KeMOZEEvEeHVEJRHEhV-jhou-9nZvUN9e7Kc2Pu5yCC2VsUmzWaZyGYM0cUixNiM2PevVxLs19dD5vU4jb5u7b-V66iS6Y6kjTMjwHTtG73gzFf3g5T9D95cXd-rq9_X51sz6_bS3lbG69UBuvQDEujRUeEwaOYtz31lnaM2843xiHnQVwwITphIX60KmNomC9oifo66F3Wjajd7bul82gpxxGk3c6maD_VWJ41Nv0SwMGJhWTteHzS0NOPxdfZj2GYv0wmOjTUjRRWHElJNkPIwerzamU7PvXOYD1Hoo-QNEVin6GokUNffp7w9fIHwrVQA-GUqW49Vk_pSXH-mv_q_0NT5SaEA</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Ratnakar, V.</creator><creator>Pawar, Sawankumar</creator><creator>Dwivedi, Ashutosh</creator><creator>Masilamani, A. B. Suhas</creator><creator>Karumuri, Kishore</creator><creator>Reddy, AVGurava</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6209-7168</orcidid></search><sort><creationdate>20230501</creationdate><title>Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population</title><author>Ratnakar, V. ; Pawar, Sawankumar ; Dwivedi, Ashutosh ; Masilamani, A. B. Suhas ; Karumuri, Kishore ; Reddy, AVGurava</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-e68be818457ac6e0241d300ffcdc3f4ea55bad0dc11d146a96c1bad98b831ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Conservative Orthopedics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Surgical Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ratnakar, V.</creatorcontrib><creatorcontrib>Pawar, Sawankumar</creatorcontrib><creatorcontrib>Dwivedi, Ashutosh</creatorcontrib><creatorcontrib>Masilamani, A. B. Suhas</creatorcontrib><creatorcontrib>Karumuri, Kishore</creatorcontrib><creatorcontrib>Reddy, AVGurava</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ratnakar, V.</au><au>Pawar, Sawankumar</au><au>Dwivedi, Ashutosh</au><au>Masilamani, A. B. Suhas</au><au>Karumuri, Kishore</au><au>Reddy, AVGurava</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population</atitle><jtitle>Indian journal of orthopaedics</jtitle><stitle>JOIO</stitle><addtitle>Indian J Orthop</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>57</volume><issue>5</issue><spage>673</spage><epage>678</epage><pages>673-678</pages><issn>0019-5413</issn><eissn>1998-3727</eissn><abstract>Background
The number of hypothyroidism patients undergoing total knee replacement (TKA) in India is increasing. It is assumed that patients with hypothyroidism are more prone to complications following surgery. The aim of this study is to evaluate the impact of hypothyroidism on the complications following TKA.
Methods
This is a case–control analysis of patients who underwent primary total knee replacement in our hospital from 2017 to 2019. A total of 600 patients were included in the study, of which 300 patients were with hypothyroidism. We compared with a matched cohort of another 300 patients without hypothyroidism as control group.
Results
A total of 600 patients were analyzed (Hypothyroid group
n
= 300, Control group
n
= 300). The medical complications were found to be 6.2% in the hypothyroid group compared to 4% in control group (
p
= 1.66, odds ratio 0.61). Surgical complications in the hypothyroid group were 3% compared to 0.6% in control group (
p
= 4.53, odds ratio = 0.21), overall complication rates were not significant statistically when compared between hypothyroid and control group (
p
= 5.01, odds ratio 0.47). Subgroup analysis of complications of hypothyroid patients with euthyroid status versus uncontrolled hypothyroidism was done and we found no statistical difference in complications.
Conclusion
The conclusion can be that the rate of hospital stay, surgical site infections and complications were higher in hypothyroid group when compared with control group though statistically not significant.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>37128567</pmid><doi>10.1007/s43465-023-00841-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6209-7168</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-5413 |
| ispartof | Indian journal of orthopaedics, 2023-05, Vol.57 (5), p.673-678 |
| issn | 0019-5413 1998-3727 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Conservative Orthopedics Medicine Medicine & Public Health Original Original Article Orthopedics Surgical Orthopedics |
| title | Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population |
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