Targeting neddylation as a novel approach to lung cancer treatment (Review)

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signal...

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Veröffentlicht in:	International journal of oncology 2023-05, Vol.62 (5), p.1, Article 65
Hauptverfasser:	Tian, Zhaochun, Li, Jiafei, Ma, Ruijie, Li, Ting, Sun, Zhigang, Huang, Shuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Apoptosis Cancer Cancer therapies Care and treatment Cell cycle Development and progression Enzymes Humans Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Medical prognosis Mortality NEDD8 Protein - genetics NEDD8 Protein - metabolism Phosphatidylinositol 3-Kinases - metabolism Prognosis Proteins Regulation Respiratory agents Signal transduction Smoking Squamous cell carcinoma Tumor proteins Ubiquitin Ubiquitination Ubiquitins
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