Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study
The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtr...
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| Veröffentlicht in: | Journal of personalized medicine 2023-03, Vol.13 (4), p.577 |
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| creator | Bano, Gulnaz Imam, Mohammad Tarique Bajpai, Ram Alem, Ghada Kashyap, Varun Kumar Habib, Anwar Najmi, Abul Kalam |
| description | The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtration rate (eGFR). Levels of ANGPTL-4 and KIM-1 were estimated in urine samples. A total of 135 participants were recruited into three groups: 45 diabetes type 2 patients in the control group and 90 DKD patients in two disease groups. Concentrations of ANGPTL-4 and KIM-1 were conclusively related to the urinary albumin-creatinine ratio (UACR). Also, the levels of both ANGPTL-4 and KIM-1 were negatively associated with the eGFR. Multivariable Poisson regression analysis showed that urinary ANGPTL-4 (PR: 3.40; 95% CI: 2.32 to 4.98;
< 0.001) and KIM-1 (PR: 1.25; 95% CI: 1.14 to 1.38;
< 0.001) were prevalent in DKD patients. Receiver operating characteristic (ROC) analysis of urinary ANGPTL-4 and KIM-1 in the combined form resulted in an area under curve (AUC) of 0.967 (95%CI: 0.932-1.000;
< 0.0001) in the microalbuminuria group and 1 (95%CI: 1.000-1.000;
< 0.0001) in the macroalbuminuria group. The association of urinary levels of ANGPTL-4 and KIM-1 with UACR and eGFR and significant prevalence in the diabetic kidney disease population illustrates the diagnostic potential of these biomarkers. |
| doi_str_mv | 10.3390/jpm13040577 |
| format | Article |
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< 0.001) and KIM-1 (PR: 1.25; 95% CI: 1.14 to 1.38;
< 0.001) were prevalent in DKD patients. Receiver operating characteristic (ROC) analysis of urinary ANGPTL-4 and KIM-1 in the combined form resulted in an area under curve (AUC) of 0.967 (95%CI: 0.932-1.000;
< 0.0001) in the microalbuminuria group and 1 (95%CI: 1.000-1.000;
< 0.0001) in the macroalbuminuria group. The association of urinary levels of ANGPTL-4 and KIM-1 with UACR and eGFR and significant prevalence in the diabetic kidney disease population illustrates the diagnostic potential of these biomarkers.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm13040577</identifier><identifier>PMID: 37108963</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Albumin ; Analysis ; Angiopoietin ; Automation ; Blood pressure ; Creatinine ; Cross-sectional studies ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes therapy ; Epidermal growth factor receptors ; Glomerular filtration rate ; Glucose ; Kidney diseases ; Patients ; Precision medicine ; Proteins ; Sample size ; Type 2 diabetes ; Urine ; Variance analysis</subject><ispartof>Journal of personalized medicine, 2023-03, Vol.13 (4), p.577</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-5e3eab320a01cfa6b8148e78180b0c52a1dd54fcb9b56ff0d57c6bc9a8f33b323</citedby><cites>FETCH-LOGICAL-c477t-5e3eab320a01cfa6b8148e78180b0c52a1dd54fcb9b56ff0d57c6bc9a8f33b323</cites><orcidid>0000-0002-5991-6924 ; 0000-0001-9346-5410 ; 0000-0002-1227-2703</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146969/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146969/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37108963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bano, Gulnaz</creatorcontrib><creatorcontrib>Imam, Mohammad Tarique</creatorcontrib><creatorcontrib>Bajpai, Ram</creatorcontrib><creatorcontrib>Alem, Ghada</creatorcontrib><creatorcontrib>Kashyap, Varun Kumar</creatorcontrib><creatorcontrib>Habib, Anwar</creatorcontrib><creatorcontrib>Najmi, Abul Kalam</creatorcontrib><title>Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtration rate (eGFR). Levels of ANGPTL-4 and KIM-1 were estimated in urine samples. A total of 135 participants were recruited into three groups: 45 diabetes type 2 patients in the control group and 90 DKD patients in two disease groups. Concentrations of ANGPTL-4 and KIM-1 were conclusively related to the urinary albumin-creatinine ratio (UACR). Also, the levels of both ANGPTL-4 and KIM-1 were negatively associated with the eGFR. Multivariable Poisson regression analysis showed that urinary ANGPTL-4 (PR: 3.40; 95% CI: 2.32 to 4.98;
< 0.001) and KIM-1 (PR: 1.25; 95% CI: 1.14 to 1.38;
< 0.001) were prevalent in DKD patients. Receiver operating characteristic (ROC) analysis of urinary ANGPTL-4 and KIM-1 in the combined form resulted in an area under curve (AUC) of 0.967 (95%CI: 0.932-1.000;
< 0.0001) in the microalbuminuria group and 1 (95%CI: 1.000-1.000;
< 0.0001) in the macroalbuminuria group. The association of urinary levels of ANGPTL-4 and KIM-1 with UACR and eGFR and significant prevalence in the diabetic kidney disease population illustrates the diagnostic potential of these biomarkers.</description><subject>Albumin</subject><subject>Analysis</subject><subject>Angiopoietin</subject><subject>Automation</subject><subject>Blood pressure</subject><subject>Creatinine</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes therapy</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerular filtration rate</subject><subject>Glucose</subject><subject>Kidney diseases</subject><subject>Patients</subject><subject>Precision medicine</subject><subject>Proteins</subject><subject>Sample size</subject><subject>Type 2 diabetes</subject><subject>Urine</subject><subject>Variance analysis</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptklFvFCEQxzdGY5vaJ98NiS8mZissy7LrizmvrTZeo_H0mbDscHJlYQu7xvtm_XhybT2vRngAht_8mRkmy54TfEJpg9-sh55QXGLG-aPssMCc5WVZVI_39gfZcYxrnEbNiqLCT7MDygmum4oeZjdnv4YAMRrvkNdo5lbGDx5G4_KFuQL0JfgR0qFE0nXok-kcbNCFW09hgy69BTVZyAmSMZFgTW-cTDenRq6cj6NR6FKGKwgRaR-25hZGiPlXsHKEnd6piSAjvEUztDRuZQHNwY0Q8vfJ2qF58DHmS1BjilJatBynbvMse6KljXB8vx5l38_Pvs0_5ovPHy7ms0WuSs7HnAEF2dICS0yUllVbk7IGXpMat1ixQpKuY6VWbdOySmvcMa6qVjWy1pQmP3qUvbvTHaa2h06lwIK0YgimT5kKL414eOPMD7HyPwXBpKyaqkkKr-4Vgr-eII6iN1GBtdKBn6IoaswbQhnhCX35D7r2U0g531IVY3VZkb_USloQxmmfHlZbUTHj6YubprjVOvkPlWYHvVHegTbJ_sDh9Z2D2tY7gN4lSbDYNpvYa7ZEv9ivy47901r0Nx4Y0P0</recordid><startdate>20230324</startdate><enddate>20230324</enddate><creator>Bano, Gulnaz</creator><creator>Imam, Mohammad Tarique</creator><creator>Bajpai, Ram</creator><creator>Alem, Ghada</creator><creator>Kashyap, Varun Kumar</creator><creator>Habib, Anwar</creator><creator>Najmi, Abul Kalam</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5991-6924</orcidid><orcidid>https://orcid.org/0000-0001-9346-5410</orcidid><orcidid>https://orcid.org/0000-0002-1227-2703</orcidid></search><sort><creationdate>20230324</creationdate><title>Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study</title><author>Bano, Gulnaz ; Imam, Mohammad Tarique ; Bajpai, Ram ; Alem, Ghada ; Kashyap, Varun Kumar ; Habib, Anwar ; Najmi, Abul Kalam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-5e3eab320a01cfa6b8148e78180b0c52a1dd54fcb9b56ff0d57c6bc9a8f33b323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albumin</topic><topic>Analysis</topic><topic>Angiopoietin</topic><topic>Automation</topic><topic>Blood pressure</topic><topic>Creatinine</topic><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes therapy</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerular filtration rate</topic><topic>Glucose</topic><topic>Kidney diseases</topic><topic>Patients</topic><topic>Precision medicine</topic><topic>Proteins</topic><topic>Sample size</topic><topic>Type 2 diabetes</topic><topic>Urine</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bano, Gulnaz</creatorcontrib><creatorcontrib>Imam, Mohammad Tarique</creatorcontrib><creatorcontrib>Bajpai, Ram</creatorcontrib><creatorcontrib>Alem, Ghada</creatorcontrib><creatorcontrib>Kashyap, Varun Kumar</creatorcontrib><creatorcontrib>Habib, Anwar</creatorcontrib><creatorcontrib>Najmi, Abul Kalam</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bano, Gulnaz</au><au>Imam, Mohammad Tarique</au><au>Bajpai, Ram</au><au>Alem, Ghada</au><au>Kashyap, Varun Kumar</au><au>Habib, Anwar</au><au>Najmi, Abul Kalam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study</atitle><jtitle>Journal of personalized medicine</jtitle><addtitle>J Pers Med</addtitle><date>2023-03-24</date><risdate>2023</risdate><volume>13</volume><issue>4</issue><spage>577</spage><pages>577-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtration rate (eGFR). Levels of ANGPTL-4 and KIM-1 were estimated in urine samples. A total of 135 participants were recruited into three groups: 45 diabetes type 2 patients in the control group and 90 DKD patients in two disease groups. Concentrations of ANGPTL-4 and KIM-1 were conclusively related to the urinary albumin-creatinine ratio (UACR). Also, the levels of both ANGPTL-4 and KIM-1 were negatively associated with the eGFR. Multivariable Poisson regression analysis showed that urinary ANGPTL-4 (PR: 3.40; 95% CI: 2.32 to 4.98;
< 0.001) and KIM-1 (PR: 1.25; 95% CI: 1.14 to 1.38;
< 0.001) were prevalent in DKD patients. Receiver operating characteristic (ROC) analysis of urinary ANGPTL-4 and KIM-1 in the combined form resulted in an area under curve (AUC) of 0.967 (95%CI: 0.932-1.000;
< 0.0001) in the microalbuminuria group and 1 (95%CI: 1.000-1.000;
< 0.0001) in the macroalbuminuria group. The association of urinary levels of ANGPTL-4 and KIM-1 with UACR and eGFR and significant prevalence in the diabetic kidney disease population illustrates the diagnostic potential of these biomarkers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37108963</pmid><doi>10.3390/jpm13040577</doi><orcidid>https://orcid.org/0000-0002-5991-6924</orcidid><orcidid>https://orcid.org/0000-0001-9346-5410</orcidid><orcidid>https://orcid.org/0000-0002-1227-2703</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Albumin Analysis Angiopoietin Automation Blood pressure Creatinine Cross-sectional studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes therapy Epidermal growth factor receptors Glomerular filtration rate Glucose Kidney diseases Patients Precision medicine Proteins Sample size Type 2 diabetes Urine Variance analysis |
| title | Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study |
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