c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD

Stress granules are the RNA/protein condensates assembled in the cells under stress. They play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, how stress granule assembly is regulated and related to ALS/FTD pathomechanism is inco...

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Veröffentlicht in:	The Journal of neuroscience 2023-04, Vol.43 (17), p.3186-3197
Hauptverfasser:	Sahana, Talanjeri Gopalakrishna, Chase, Katherine Johnson, Liu, Feilin, Lloyd, Thomas E, Rossoll, Wilfried, Zhang, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Animals Assembly c-Jun protein C9orf72 Protein - genetics Cellular stress response Dementia disorders Dipeptides - genetics Dipeptides - metabolism DNA Helicases - metabolism Drosophila melanogaster Female Frontotemporal dementia Frontotemporal Dementia - genetics Frontotemporal Dementia - metabolism Granular materials Histones Humans JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Male Mutation Neurodegeneration Neurotoxicity Pathogenesis Phosphorylation Pluripotency Poly-ADP-Ribose Binding Proteins Proteins RNA Helicases - metabolism RNA Recognition Motif Proteins Stem cells Stress Granules Transcription factors
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