Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites
Due to the emergence of antibiotic-resistant pathogens, the need to find new, efficient antimicrobial agents is rapidly increasing. Therefore, in this study, we report the development of new biocomposites based on zinc-doped hydroxyapatite/chitosan enriched with essential oil of L. with good antimic...
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| Veröffentlicht in: | Polymers 2023-04, Vol.15 (8), p.1908 |
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| creator | Predoi, Daniela Iconaru, Simona Liliana Ciobanu, Carmen Steluta Raita, Mariana Stefania Ghegoiu, Liliana Trusca, Roxana Badea, Monica Luminita Cimpeanu, Carmen |
| description | Due to the emergence of antibiotic-resistant pathogens, the need to find new, efficient antimicrobial agents is rapidly increasing. Therefore, in this study, we report the development of new biocomposites based on zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L. with good antimicrobial activity. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used in order to evaluate their physico-chemical properties. Our studies revealed that biocomposite materials with nanometric dimension and homogeneous composition could be obtained through an economic and cost-effective synthesis method. The biological assays demonstrated that ZnHA (zinc-doped hydroxyapatite), ZnHACh (zinc-doped hydroxyapatite/chitosan) and ZnHAChT (zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L.) did not exhibit a toxic effect on the cell viability and proliferation of the primary osteoblast culture (hFOB 1.19). Moreover, the cytotoxic assay also highlighted that the cell morphology of the hFOB 1.19 was not altered in the presence of ZnHA, ZnHACh or ZnHAChT. Furthermore, the in vitro antimicrobial studies emphasized that the samples exhibited strong antimicrobial properties against
ATCC 25922,
ATCC 25923 and
ATCC 10231 microbial strains. These results are encouraging for the following development of new composite materials with enhanced biological properties that could promote the osteogenic process of bone healing and also exhibit good antimicrobial properties. |
| doi_str_mv | 10.3390/polym15081908 |
| format | Article |
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L. with good antimicrobial activity. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used in order to evaluate their physico-chemical properties. Our studies revealed that biocomposite materials with nanometric dimension and homogeneous composition could be obtained through an economic and cost-effective synthesis method. The biological assays demonstrated that ZnHA (zinc-doped hydroxyapatite), ZnHACh (zinc-doped hydroxyapatite/chitosan) and ZnHAChT (zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L.) did not exhibit a toxic effect on the cell viability and proliferation of the primary osteoblast culture (hFOB 1.19). Moreover, the cytotoxic assay also highlighted that the cell morphology of the hFOB 1.19 was not altered in the presence of ZnHA, ZnHACh or ZnHAChT. Furthermore, the in vitro antimicrobial studies emphasized that the samples exhibited strong antimicrobial properties against
ATCC 25922,
ATCC 25923 and
ATCC 10231 microbial strains. These results are encouraging for the following development of new composite materials with enhanced biological properties that could promote the osteogenic process of bone healing and also exhibit good antimicrobial properties.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym15081908</identifier><identifier>PMID: 37112055</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biological properties ; Biomedical materials ; Bones ; Chemical properties ; Chitosan ; Composite materials ; Diffraction ; E coli ; Escherichia coli ; Essential oils ; Fourier transforms ; Hydroxyapatite ; Infectious diseases ; Infrared spectroscopy ; Microorganisms ; Molecular weight ; Morphology ; Oils & fats ; Public health ; Scanning electron microscopy ; Spectrum analysis ; X-ray spectroscopy ; X-rays ; Zinc</subject><ispartof>Polymers, 2023-04, Vol.15 (8), p.1908</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-2de32a7901cb94ed71fd23f9c5fe371c00511857f6b896ab5d4173f694ab6a7f3</citedby><cites>FETCH-LOGICAL-c483t-2de32a7901cb94ed71fd23f9c5fe371c00511857f6b896ab5d4173f694ab6a7f3</cites><orcidid>0000-0002-6044-4311 ; 0000-0002-9139-5903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142985/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142985/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37112055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predoi, Daniela</creatorcontrib><creatorcontrib>Iconaru, Simona Liliana</creatorcontrib><creatorcontrib>Ciobanu, Carmen Steluta</creatorcontrib><creatorcontrib>Raita, Mariana Stefania</creatorcontrib><creatorcontrib>Ghegoiu, Liliana</creatorcontrib><creatorcontrib>Trusca, Roxana</creatorcontrib><creatorcontrib>Badea, Monica Luminita</creatorcontrib><creatorcontrib>Cimpeanu, Carmen</creatorcontrib><title>Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Due to the emergence of antibiotic-resistant pathogens, the need to find new, efficient antimicrobial agents is rapidly increasing. Therefore, in this study, we report the development of new biocomposites based on zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L. with good antimicrobial activity. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used in order to evaluate their physico-chemical properties. Our studies revealed that biocomposite materials with nanometric dimension and homogeneous composition could be obtained through an economic and cost-effective synthesis method. The biological assays demonstrated that ZnHA (zinc-doped hydroxyapatite), ZnHACh (zinc-doped hydroxyapatite/chitosan) and ZnHAChT (zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L.) did not exhibit a toxic effect on the cell viability and proliferation of the primary osteoblast culture (hFOB 1.19). Moreover, the cytotoxic assay also highlighted that the cell morphology of the hFOB 1.19 was not altered in the presence of ZnHA, ZnHACh or ZnHAChT. Furthermore, the in vitro antimicrobial studies emphasized that the samples exhibited strong antimicrobial properties against
ATCC 25922,
ATCC 25923 and
ATCC 10231 microbial strains. These results are encouraging for the following development of new composite materials with enhanced biological properties that could promote the osteogenic process of bone healing and also exhibit good antimicrobial properties.</description><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biological properties</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Chemical properties</subject><subject>Chitosan</subject><subject>Composite materials</subject><subject>Diffraction</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Essential oils</subject><subject>Fourier transforms</subject><subject>Hydroxyapatite</subject><subject>Infectious diseases</subject><subject>Infrared spectroscopy</subject><subject>Microorganisms</subject><subject>Molecular weight</subject><subject>Morphology</subject><subject>Oils & fats</subject><subject>Public health</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>X-ray spectroscopy</subject><subject>X-rays</subject><subject>Zinc</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptksFvFCEUxonR2Kb26NVM4sXLtDDAMJxMXVdr0qQH65kwzGOXZgZGYBr3v5dta-0aeQfI4_e-x0ceQm8JPqNU4vM5jLuJcNwRibsX6LjBgtaMtvjls_MROk3pFpfFeNsS8RodUUFIgzk_Rul7XgYHqQq2yluobnSMehN8tU4JfHZ6rK7dWK2tBZML5e-p1VZHbTJEl7Iz98WfwwxDdbkbYvi107POLsP5autySNpXn1wwYZpDKtn0Br2yekxw-rifoB9f1jery_rq-uu31cVVbVhHc90MQBstJCamlwwGQezQUCsNt1AMGIw5IR0Xtu072eqeD4wIalvJdN9qYekJ-vigOy_9BIMpfqIe1RzdpONOBe3U4Y13W7UJd4pgwhrZ8aLw4VEhhp8LpKwmlwyMo_YQlqSaDpf3SYZxQd__g96GJfrib0-1XAjK6F9qo0dQzttQGpu9qLoQrMS-c6HO_kOVGGByJniwruQPCuqHAhNDShHsk0mC1X5S1MGkFP7d8595ov_MBf0Ng3i6Mg</recordid><startdate>20230416</startdate><enddate>20230416</enddate><creator>Predoi, Daniela</creator><creator>Iconaru, Simona Liliana</creator><creator>Ciobanu, Carmen Steluta</creator><creator>Raita, Mariana Stefania</creator><creator>Ghegoiu, Liliana</creator><creator>Trusca, Roxana</creator><creator>Badea, Monica Luminita</creator><creator>Cimpeanu, Carmen</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6044-4311</orcidid><orcidid>https://orcid.org/0000-0002-9139-5903</orcidid></search><sort><creationdate>20230416</creationdate><title>Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites</title><author>Predoi, Daniela ; Iconaru, Simona Liliana ; Ciobanu, Carmen Steluta ; Raita, Mariana Stefania ; Ghegoiu, Liliana ; Trusca, Roxana ; Badea, Monica Luminita ; Cimpeanu, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-2de32a7901cb94ed71fd23f9c5fe371c00511857f6b896ab5d4173f694ab6a7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Biological properties</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Chemical properties</topic><topic>Chitosan</topic><topic>Composite materials</topic><topic>Diffraction</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Essential oils</topic><topic>Fourier transforms</topic><topic>Hydroxyapatite</topic><topic>Infectious diseases</topic><topic>Infrared spectroscopy</topic><topic>Microorganisms</topic><topic>Molecular weight</topic><topic>Morphology</topic><topic>Oils & fats</topic><topic>Public health</topic><topic>Scanning electron microscopy</topic><topic>Spectrum analysis</topic><topic>X-ray spectroscopy</topic><topic>X-rays</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Predoi, Daniela</creatorcontrib><creatorcontrib>Iconaru, Simona Liliana</creatorcontrib><creatorcontrib>Ciobanu, Carmen Steluta</creatorcontrib><creatorcontrib>Raita, Mariana Stefania</creatorcontrib><creatorcontrib>Ghegoiu, Liliana</creatorcontrib><creatorcontrib>Trusca, Roxana</creatorcontrib><creatorcontrib>Badea, Monica Luminita</creatorcontrib><creatorcontrib>Cimpeanu, Carmen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Predoi, Daniela</au><au>Iconaru, Simona Liliana</au><au>Ciobanu, Carmen Steluta</au><au>Raita, Mariana Stefania</au><au>Ghegoiu, Liliana</au><au>Trusca, Roxana</au><au>Badea, Monica Luminita</au><au>Cimpeanu, Carmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2023-04-16</date><risdate>2023</risdate><volume>15</volume><issue>8</issue><spage>1908</spage><pages>1908-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Due to the emergence of antibiotic-resistant pathogens, the need to find new, efficient antimicrobial agents is rapidly increasing. Therefore, in this study, we report the development of new biocomposites based on zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L. with good antimicrobial activity. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used in order to evaluate their physico-chemical properties. Our studies revealed that biocomposite materials with nanometric dimension and homogeneous composition could be obtained through an economic and cost-effective synthesis method. The biological assays demonstrated that ZnHA (zinc-doped hydroxyapatite), ZnHACh (zinc-doped hydroxyapatite/chitosan) and ZnHAChT (zinc-doped hydroxyapatite/chitosan enriched with essential oil of
L.) did not exhibit a toxic effect on the cell viability and proliferation of the primary osteoblast culture (hFOB 1.19). Moreover, the cytotoxic assay also highlighted that the cell morphology of the hFOB 1.19 was not altered in the presence of ZnHA, ZnHACh or ZnHAChT. Furthermore, the in vitro antimicrobial studies emphasized that the samples exhibited strong antimicrobial properties against
ATCC 25922,
ATCC 25923 and
ATCC 10231 microbial strains. These results are encouraging for the following development of new composite materials with enhanced biological properties that could promote the osteogenic process of bone healing and also exhibit good antimicrobial properties.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37112055</pmid><doi>10.3390/polym15081908</doi><orcidid>https://orcid.org/0000-0002-6044-4311</orcidid><orcidid>https://orcid.org/0000-0002-9139-5903</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics Antiinfectives and antibacterials Antimicrobial agents Biological properties Biomedical materials Bones Chemical properties Chitosan Composite materials Diffraction E coli Escherichia coli Essential oils Fourier transforms Hydroxyapatite Infectious diseases Infrared spectroscopy Microorganisms Molecular weight Morphology Oils & fats Public health Scanning electron microscopy Spectrum analysis X-ray spectroscopy X-rays Zinc |
| title | Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites |
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