Scoliosis in rats with experimentally-induced hemiparkinsonism: dependence upon striatal dopamine denervation
Rats suffering from experimental hemiparkinsonism induced by a unilateral injection of 6-hydroxydopamine into the left area ventralis tegmenti showed a strong ipsilateral deviation and scoliosis-like skeletal deformity. The rats often showed single rotatory curves affecting the thoracic and lumbar r...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1990-01, Vol.53 (1), p.39-43 |
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| creator | Herrera-Marschitz, M Utsumi, H Ungerstedt, U |
| description | Rats suffering from experimental hemiparkinsonism induced by a unilateral injection of 6-hydroxydopamine into the left area ventralis tegmenti showed a strong ipsilateral deviation and scoliosis-like skeletal deformity. The rats often showed single rotatory curves affecting the thoracic and lumbar regions, although cases with multiple curves were also found. The severity of the scoliosis was closely related to a decrease in extracellular striatal dopamine measured with microdialysis and to the development of postsynaptic dopamine receptor supersensitivity, functionally evaluated with rotational behaviour elicited with apomorphine. Indeed, rats with the strongest dopamine depletion (greater than 95%) and the strongest rotational responses showed the sharpest spinal deviation and skeletal deformity. These findings agree with the clinical observations that scoliosis occurs in patients with Parkinson's disease and its direction is correlated with the side of the major signs and symptoms of parkinsonism. |
| doi_str_mv | 10.1136/jnnp.53.1.39 |
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The rats often showed single rotatory curves affecting the thoracic and lumbar regions, although cases with multiple curves were also found. The severity of the scoliosis was closely related to a decrease in extracellular striatal dopamine measured with microdialysis and to the development of postsynaptic dopamine receptor supersensitivity, functionally evaluated with rotational behaviour elicited with apomorphine. Indeed, rats with the strongest dopamine depletion (greater than 95%) and the strongest rotational responses showed the sharpest spinal deviation and skeletal deformity. 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The rats often showed single rotatory curves affecting the thoracic and lumbar regions, although cases with multiple curves were also found. The severity of the scoliosis was closely related to a decrease in extracellular striatal dopamine measured with microdialysis and to the development of postsynaptic dopamine receptor supersensitivity, functionally evaluated with rotational behaviour elicited with apomorphine. Indeed, rats with the strongest dopamine depletion (greater than 95%) and the strongest rotational responses showed the sharpest spinal deviation and skeletal deformity. These findings agree with the clinical observations that scoliosis occurs in patients with Parkinson's disease and its direction is correlated with the side of the major signs and symptoms of parkinsonism.</description><subject>Afferent Pathways - physiopathology</subject><subject>Animals</subject><subject>Corpus Striatum - physiology</subject><subject>Disease Models, Animal</subject><subject>Dominance, Cerebral - physiology</subject><subject>Dopamine - physiology</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Neurons - physiology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - physiology</subject><subject>Scoliosis - physiopathology</subject><subject>Stereotyped Behavior - physiology</subject><subject>Substantia Nigra - physiology</subject><subject>Tegmentum Mesencephali - physiopathology</subject><subject>Telencephalon - physiopathology</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUuLFDEUhYMoY8_ozq1QIOjGavOovFwI0owPHBRxFHETkqrbdtqqpEyqxpl_b5puGnVhNlmcLyf33IPQA4KXhDDxbBvCuORsSZZM30IL0ghVM4a_3kYLjCmtGeb4LjrNeYt3R-kTdEIZZorhBRo-tbH3Mftc-VAlO-Xql582FVyPkPwAYbJ9f1P70M0tdNUGBj_a9MOHHIPPw_OqgxFCB6GFah5jqPKUvC2Pqi6OdvABChEgXdnJx3AP3VnbPsP9w32GPr86v1y9qS8-vH67enlRu0bKqVYYC-aEtZapNemEa4UFjhnHtuW6FdR1a-p0p4TGttGucVQ7pjlwTR2njp2hF3vfcXYDdG2JkWxvxpLIphsTrTd_K8FvzPd4ZQgmDda8GDw-GKT4c4Y8mcHnFvreBohzNlILSpVkBXz0D7iNcwolnCFS7rassCrU0z3VpphzgvVxFILNrkSzK9FwZohhuuAP_xz_CB9aK3q9132e4Pool16MkExy8_7LypBv7z5KjqW5LPyTPe-G7f9__g19nrf6</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Herrera-Marschitz, M</creator><creator>Utsumi, H</creator><creator>Ungerstedt, U</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199001</creationdate><title>Scoliosis in rats with experimentally-induced hemiparkinsonism: dependence upon striatal dopamine denervation</title><author>Herrera-Marschitz, M ; 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| issn | 0022-3050 1468-330X |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Afferent Pathways - physiopathology Animals Corpus Striatum - physiology Disease Models, Animal Dominance, Cerebral - physiology Dopamine - physiology Male Motor Activity - physiology Neurons - physiology Parkinson Disease - physiopathology Rats Rats, Inbred Strains Receptors, Dopamine - physiology Scoliosis - physiopathology Stereotyped Behavior - physiology Substantia Nigra - physiology Tegmentum Mesencephali - physiopathology Telencephalon - physiopathology |
| title | Scoliosis in rats with experimentally-induced hemiparkinsonism: dependence upon striatal dopamine denervation |
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