The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer
Given their tumor-specific and stage-specific gene expression, long non-coding RNAs (lncRNAs) have demonstrated to be potential molecular biomarkers for diagnosis, prognosis, and treatment response. Particularly, the lncRNAs and serve as examples of this because of their high subtype-specific expres...
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| Veröffentlicht in: | International journal of molecular sciences 2023-04, Vol.24 (8), p.7426 |
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| creator | Arriaga-Canon, Cristian Contreras-Espinosa, Laura Aguilar-Villanueva, Sergio Bargalló-Rocha, Enrique García-Gordillo, José Antonio Cabrera-Galeana, Paula Castro-Hernández, Clementina Jiménez-Trejo, Francisco Herrera, L A |
| description | Given their tumor-specific and stage-specific gene expression, long non-coding RNAs (lncRNAs) have demonstrated to be potential molecular biomarkers for diagnosis, prognosis, and treatment response. Particularly, the lncRNAs
and
serve as examples of this because of their high subtype-specific expression profile in luminal B-like breast cancer. This makes them candidates to use as molecular biomarkers in clinical practice. However, lncRNA studies in breast cancer are limited in sample size and are restricted to the determination of their biological function, which represents an obstacle for its inclusion as molecular biomarkers of clinical utility. Nevertheless, due to their expression specificity among diseases, such as cancer, and their stability in body fluids, lncRNAs are promising molecular biomarkers that could improve the reliability, sensitivity, and specificity of molecular techniques used in clinical diagnosis. The development of lncRNA-based diagnostics and lncRNA-based therapeutics will be useful in routine medical practice to improve patient clinical management and quality of life. |
| doi_str_mv | 10.3390/ijms24087426 |
| format | Article |
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and
serve as examples of this because of their high subtype-specific expression profile in luminal B-like breast cancer. This makes them candidates to use as molecular biomarkers in clinical practice. However, lncRNA studies in breast cancer are limited in sample size and are restricted to the determination of their biological function, which represents an obstacle for its inclusion as molecular biomarkers of clinical utility. Nevertheless, due to their expression specificity among diseases, such as cancer, and their stability in body fluids, lncRNAs are promising molecular biomarkers that could improve the reliability, sensitivity, and specificity of molecular techniques used in clinical diagnosis. The development of lncRNA-based diagnostics and lncRNA-based therapeutics will be useful in routine medical practice to improve patient clinical management and quality of life.</description><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24087426</identifier><identifier>PMID: 37108589</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biological markers ; Biomarkers ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Development and progression ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; Pertuzumab ; Prognosis ; Quality of Life ; Reproducibility of Results ; Review ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism</subject><ispartof>International journal of molecular sciences, 2023-04, Vol.24 (8), p.7426</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-6de208cf4e7b8b1cc6b840637325ae46ed410f2b7a089973ade1479d185f4a443</citedby><cites>FETCH-LOGICAL-c452t-6de208cf4e7b8b1cc6b840637325ae46ed410f2b7a089973ade1479d185f4a443</cites><orcidid>0000-0003-3998-9306 ; 0000-0002-0118-2390 ; 0000-0002-5641-3627</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138835/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138835/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37108589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arriaga-Canon, Cristian</creatorcontrib><creatorcontrib>Contreras-Espinosa, Laura</creatorcontrib><creatorcontrib>Aguilar-Villanueva, Sergio</creatorcontrib><creatorcontrib>Bargalló-Rocha, Enrique</creatorcontrib><creatorcontrib>García-Gordillo, José Antonio</creatorcontrib><creatorcontrib>Cabrera-Galeana, Paula</creatorcontrib><creatorcontrib>Castro-Hernández, Clementina</creatorcontrib><creatorcontrib>Jiménez-Trejo, Francisco</creatorcontrib><creatorcontrib>Herrera, L A</creatorcontrib><title>The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Given their tumor-specific and stage-specific gene expression, long non-coding RNAs (lncRNAs) have demonstrated to be potential molecular biomarkers for diagnosis, prognosis, and treatment response. Particularly, the lncRNAs
and
serve as examples of this because of their high subtype-specific expression profile in luminal B-like breast cancer. This makes them candidates to use as molecular biomarkers in clinical practice. However, lncRNA studies in breast cancer are limited in sample size and are restricted to the determination of their biological function, which represents an obstacle for its inclusion as molecular biomarkers of clinical utility. Nevertheless, due to their expression specificity among diseases, such as cancer, and their stability in body fluids, lncRNAs are promising molecular biomarkers that could improve the reliability, sensitivity, and specificity of molecular techniques used in clinical diagnosis. The development of lncRNA-based diagnostics and lncRNA-based therapeutics will be useful in routine medical practice to improve patient clinical management and quality of life.</description><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Pertuzumab</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Reproducibility of Results</subject><subject>Review</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><issn>1422-0067</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9LHDEcxYNU1NrePEuglx66ml8zSU5lXWoVtIWi14ZM5jsam0m2yWzB_94sa2UFySHhm897vC8PoSNKTjjX5NQ_jIUJoqRg7Q46oIKxGSGtfLf13kfvS3kghHHW6D20zyUlqlH6AP2-uQe8CD56ZwO-nXzw0yNOAw7R_foxL9jGHlfGZzxfLkOlJp8itgVfpwBuFWzGZz6NNv-BXLCP-CyDLRNe2Oggf0C7gw0FPj7fh-j2_NvN4mJ29fP75WJ-NXOiYdOs7YER5QYBslMdda7tlCAtlzWvBdFCLygZWCctUVpLbnugQuqeqmYQVgh-iL5ufJerboTeQZyyDWaZfU32aJL15vVP9PfmLv0zlFCuFG-qw-dnh5z-rqBMZvTFQQg2QloVwxSRmrKG6Yp-2qB3NoDxcUjV0q1xM5cN1UwJvqZO3qDq6WH0LkUYfJ2_EnzZCFxOpWQYXuJTYtZVm-2qK368vfIL_L9b_gRidKO4</recordid><startdate>20230418</startdate><enddate>20230418</enddate><creator>Arriaga-Canon, Cristian</creator><creator>Contreras-Espinosa, Laura</creator><creator>Aguilar-Villanueva, Sergio</creator><creator>Bargalló-Rocha, Enrique</creator><creator>García-Gordillo, José Antonio</creator><creator>Cabrera-Galeana, Paula</creator><creator>Castro-Hernández, Clementina</creator><creator>Jiménez-Trejo, Francisco</creator><creator>Herrera, L A</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3998-9306</orcidid><orcidid>https://orcid.org/0000-0002-0118-2390</orcidid><orcidid>https://orcid.org/0000-0002-5641-3627</orcidid></search><sort><creationdate>20230418</creationdate><title>The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer</title><author>Arriaga-Canon, Cristian ; Contreras-Espinosa, Laura ; Aguilar-Villanueva, Sergio ; Bargalló-Rocha, Enrique ; García-Gordillo, José Antonio ; Cabrera-Galeana, Paula ; Castro-Hernández, Clementina ; Jiménez-Trejo, Francisco ; Herrera, L A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-6de208cf4e7b8b1cc6b840637325ae46ed410f2b7a089973ade1479d185f4a443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Development and progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Pertuzumab</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Reproducibility of Results</topic><topic>Review</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arriaga-Canon, Cristian</creatorcontrib><creatorcontrib>Contreras-Espinosa, Laura</creatorcontrib><creatorcontrib>Aguilar-Villanueva, Sergio</creatorcontrib><creatorcontrib>Bargalló-Rocha, Enrique</creatorcontrib><creatorcontrib>García-Gordillo, José Antonio</creatorcontrib><creatorcontrib>Cabrera-Galeana, Paula</creatorcontrib><creatorcontrib>Castro-Hernández, Clementina</creatorcontrib><creatorcontrib>Jiménez-Trejo, Francisco</creatorcontrib><creatorcontrib>Herrera, L A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arriaga-Canon, Cristian</au><au>Contreras-Espinosa, Laura</au><au>Aguilar-Villanueva, Sergio</au><au>Bargalló-Rocha, Enrique</au><au>García-Gordillo, José Antonio</au><au>Cabrera-Galeana, Paula</au><au>Castro-Hernández, Clementina</au><au>Jiménez-Trejo, Francisco</au><au>Herrera, L A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-04-18</date><risdate>2023</risdate><volume>24</volume><issue>8</issue><spage>7426</spage><pages>7426-</pages><issn>1422-0067</issn><eissn>1422-0067</eissn><abstract>Given their tumor-specific and stage-specific gene expression, long non-coding RNAs (lncRNAs) have demonstrated to be potential molecular biomarkers for diagnosis, prognosis, and treatment response. Particularly, the lncRNAs
and
serve as examples of this because of their high subtype-specific expression profile in luminal B-like breast cancer. This makes them candidates to use as molecular biomarkers in clinical practice. However, lncRNA studies in breast cancer are limited in sample size and are restricted to the determination of their biological function, which represents an obstacle for its inclusion as molecular biomarkers of clinical utility. Nevertheless, due to their expression specificity among diseases, such as cancer, and their stability in body fluids, lncRNAs are promising molecular biomarkers that could improve the reliability, sensitivity, and specificity of molecular techniques used in clinical diagnosis. The development of lncRNA-based diagnostics and lncRNA-based therapeutics will be useful in routine medical practice to improve patient clinical management and quality of life.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37108589</pmid><doi>10.3390/ijms24087426</doi><orcidid>https://orcid.org/0000-0003-3998-9306</orcidid><orcidid>https://orcid.org/0000-0002-0118-2390</orcidid><orcidid>https://orcid.org/0000-0002-5641-3627</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biological markers Biomarkers Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Development and progression Female Gene expression Gene Expression Regulation, Neoplastic Humans Pertuzumab Prognosis Quality of Life Reproducibility of Results Review RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| title | The Clinical Utility of lncRNAs and Their Application as Molecular Biomarkers in Breast Cancer |
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