Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking

The selectivity of drugs for G protein-coupled receptor (GPCR) signaling pathways is crucial for their therapeutic efficacy. Different agonists can cause receptors to recruit effector proteins at varying levels, thus inducing different signaling responses, called signaling bias. Although several GPC...

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Veröffentlicht in:	International journal of molecular sciences 2023-04, Vol.24 (8), p.7356
Hauptverfasser:	Wang, Dongxue, Yao, Yunjin, Wang, Shiqi, Hou, Yifei, Zhao, Lanxue, Wang, Hao, Chen, Hongzhuan, Xu, Jianrong
Format:	Artikel
Sprache:	eng
Schlagworte:	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride Acetylcholine beta-Arrestin 1 - metabolism beta-Arrestin 2 - metabolism beta-Arrestins - metabolism Energy Transfer G proteins GTP-Binding Proteins - metabolism Health aspects HEK293 Cells Humans Molecular Docking Simulation Pilocarpine - pharmacology Proteins Receptor, Muscarinic M1 - metabolism
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