Antibiotics Significantly Decrease the Survival of Head and Neck Carcinoma Patients with Immunotherapy: A Real-World Analysis of More Than 3000 Cases

The human gut microbiome is strongly influenced by the administration of drugs, namely antibiotics. We hypothesized that the effectiveness of immunotherapy with pembrolizumab in oral squamous cell carcinoma patients is decreased by the administration of antibiotics three months before and after immu...

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Veröffentlicht in:	Cancers 2023-04, Vol.15 (8), p.2342
Hauptverfasser:	Preissner, Saskia, Heiland, Max, Preissner, Robert, Wirth, Markus, Wollenberg, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Body mass index Cancer Carcinoma Chemotherapy Communication Dosage and administration Drug dependence Drug metabolism Drug therapy Head and neck cancer Head and neck carcinoma Immunotherapy Intestinal microflora Lymph nodes Lymphatic system Medical records Medical research Metastases Metastasis Methods Microbiomes Microbiota Oral carcinoma Oral squamous cell carcinoma Patient outcomes Patients Pembrolizumab Response rates Sepsis Survival analysis
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