Analysis of Local Recurrence Risk in Ductal Carcinoma In Situ and External Validation of the Memorial Sloan Kettering Cancer Center Nomogram
Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) in ductal carcinoma in situ (DCIS) have been shown to reduce the risk of local recurrence. To predict the risk of ipsilateral breast tumor relapse (IBTR) after BCS, the Memorial Sloan Kettering Cancer Center (MSKCC) devel...
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| Veröffentlicht in: | Cancers 2023-04, Vol.15 (8), p.2392 |
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| creator | Oses, Gabriela Mension, Eduard Pumarola, Claudia Castillo, Helena Francesc, León Torras, Inés Cebrecos, Isaac Caparrós, Xavier Ganau, Sergi Ubeda, Belén Bargallo, Xavier González, Blanca Sanfeliu, Esther Vidal-Sicart, Sergi Moreno, Reinaldo Muñoz, Montserrat Santamaría, Gorane Mollà, Meritxell |
| description | Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) in ductal carcinoma in situ (DCIS) have been shown to reduce the risk of local recurrence. To predict the risk of ipsilateral breast tumor relapse (IBTR) after BCS, the Memorial Sloan Kettering Cancer Center (MSKCC) developed a nomogram to analyze local recurrence (LR) risk in our cohort and to assess its external validation.
A historical cohort study using data from 296 patients treated for DCIS at the Hospital Clínic of Barcelona was carried out. Patients who had had a mastectomy were excluded from the analysis.
The mean age was 58 years (42-75), and the median follow-up time was 10.64 years. The overall local relapse rate was 13.04% (27 patients) during the study period. Actuarial 5- and 10-year IBTR rates were 5.8 and 12.9%, respectively. The external validation of the MSKCC nomogram was performed using a multivariate logistic regression analysis on a total of 207 patients, which did not reach statistical significance in the studied population for predicting LR (
= 0.10). The expression of estrogen receptors was significantly associated with a decreased risk of LR (OR: 0.25;
= 0.004).
In our series, the LR rate was 13.4%, which was in accordance with the published series. The MSKCC nomogram did not accurately predict the IBTR in this Spanish cohort of patients treated for DCIS (
= 0.10). |
| doi_str_mv | 10.3390/cancers15082392 |
| format | Article |
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A historical cohort study using data from 296 patients treated for DCIS at the Hospital Clínic of Barcelona was carried out. Patients who had had a mastectomy were excluded from the analysis.
The mean age was 58 years (42-75), and the median follow-up time was 10.64 years. The overall local relapse rate was 13.04% (27 patients) during the study period. Actuarial 5- and 10-year IBTR rates were 5.8 and 12.9%, respectively. The external validation of the MSKCC nomogram was performed using a multivariate logistic regression analysis on a total of 207 patients, which did not reach statistical significance in the studied population for predicting LR (
= 0.10). The expression of estrogen receptors was significantly associated with a decreased risk of LR (OR: 0.25;
= 0.004).
In our series, the LR rate was 13.4%, which was in accordance with the published series. The MSKCC nomogram did not accurately predict the IBTR in this Spanish cohort of patients treated for DCIS (
= 0.10).</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15082392</identifier><identifier>PMID: 37190320</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Breast cancer ; Cancer ; Cancer therapies ; Carcinoma, Ductal ; Care and treatment ; Decision making ; Endocrine therapy ; Estrogen receptors ; Estrogens ; Family medical history ; Lumpectomy ; Mastectomy ; Patient outcomes ; Patients ; Population studies ; Radiation therapy ; Regression analysis ; Relapse ; Risk factors ; Statistics ; Surgery ; Tumors ; Variables</subject><ispartof>Cancers, 2023-04, Vol.15 (8), p.2392</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-44a877cb5cc317335d2a07123109b04c3e7655dac4a7915e524ff7adcb5301643</citedby><cites>FETCH-LOGICAL-c489t-44a877cb5cc317335d2a07123109b04c3e7655dac4a7915e524ff7adcb5301643</cites><orcidid>0000-0002-6586-1712 ; 0000-0002-7974-3346 ; 0000-0002-1227-1137 ; 0000-0001-6215-2251 ; 0000-0002-9333-3642 ; 0000-0001-5915-8580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136555/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136555/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37190320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oses, Gabriela</creatorcontrib><creatorcontrib>Mension, Eduard</creatorcontrib><creatorcontrib>Pumarola, Claudia</creatorcontrib><creatorcontrib>Castillo, Helena</creatorcontrib><creatorcontrib>Francesc, León</creatorcontrib><creatorcontrib>Torras, Inés</creatorcontrib><creatorcontrib>Cebrecos, Isaac</creatorcontrib><creatorcontrib>Caparrós, Xavier</creatorcontrib><creatorcontrib>Ganau, Sergi</creatorcontrib><creatorcontrib>Ubeda, Belén</creatorcontrib><creatorcontrib>Bargallo, Xavier</creatorcontrib><creatorcontrib>González, Blanca</creatorcontrib><creatorcontrib>Sanfeliu, Esther</creatorcontrib><creatorcontrib>Vidal-Sicart, Sergi</creatorcontrib><creatorcontrib>Moreno, Reinaldo</creatorcontrib><creatorcontrib>Muñoz, Montserrat</creatorcontrib><creatorcontrib>Santamaría, Gorane</creatorcontrib><creatorcontrib>Mollà, Meritxell</creatorcontrib><title>Analysis of Local Recurrence Risk in Ductal Carcinoma In Situ and External Validation of the Memorial Sloan Kettering Cancer Center Nomogram</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) in ductal carcinoma in situ (DCIS) have been shown to reduce the risk of local recurrence. To predict the risk of ipsilateral breast tumor relapse (IBTR) after BCS, the Memorial Sloan Kettering Cancer Center (MSKCC) developed a nomogram to analyze local recurrence (LR) risk in our cohort and to assess its external validation.
A historical cohort study using data from 296 patients treated for DCIS at the Hospital Clínic of Barcelona was carried out. Patients who had had a mastectomy were excluded from the analysis.
The mean age was 58 years (42-75), and the median follow-up time was 10.64 years. The overall local relapse rate was 13.04% (27 patients) during the study period. Actuarial 5- and 10-year IBTR rates were 5.8 and 12.9%, respectively. The external validation of the MSKCC nomogram was performed using a multivariate logistic regression analysis on a total of 207 patients, which did not reach statistical significance in the studied population for predicting LR (
= 0.10). The expression of estrogen receptors was significantly associated with a decreased risk of LR (OR: 0.25;
= 0.004).
In our series, the LR rate was 13.4%, which was in accordance with the published series. The MSKCC nomogram did not accurately predict the IBTR in this Spanish cohort of patients treated for DCIS (
= 0.10).</description><subject>Age</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Ductal</subject><subject>Care and treatment</subject><subject>Decision making</subject><subject>Endocrine therapy</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Family medical history</subject><subject>Lumpectomy</subject><subject>Mastectomy</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Population studies</subject><subject>Radiation therapy</subject><subject>Regression analysis</subject><subject>Relapse</subject><subject>Risk 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of Local Recurrence Risk in Ductal Carcinoma In Situ and External Validation of the Memorial Sloan Kettering Cancer Center Nomogram</title><author>Oses, Gabriela ; Mension, Eduard ; Pumarola, Claudia ; Castillo, Helena ; Francesc, León ; Torras, Inés ; Cebrecos, Isaac ; Caparrós, Xavier ; Ganau, Sergi ; Ubeda, Belén ; Bargallo, Xavier ; González, Blanca ; Sanfeliu, Esther ; Vidal-Sicart, Sergi ; Moreno, Reinaldo ; Muñoz, Montserrat ; Santamaría, Gorane ; Mollà, Meritxell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-44a877cb5cc317335d2a07123109b04c3e7655dac4a7915e524ff7adcb5301643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Ductal</topic><topic>Care and treatment</topic><topic>Decision making</topic><topic>Endocrine therapy</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Family medical history</topic><topic>Lumpectomy</topic><topic>Mastectomy</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Population studies</topic><topic>Radiation therapy</topic><topic>Regression analysis</topic><topic>Relapse</topic><topic>Risk factors</topic><topic>Statistics</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oses, Gabriela</creatorcontrib><creatorcontrib>Mension, Eduard</creatorcontrib><creatorcontrib>Pumarola, Claudia</creatorcontrib><creatorcontrib>Castillo, Helena</creatorcontrib><creatorcontrib>Francesc, León</creatorcontrib><creatorcontrib>Torras, Inés</creatorcontrib><creatorcontrib>Cebrecos, Isaac</creatorcontrib><creatorcontrib>Caparrós, Xavier</creatorcontrib><creatorcontrib>Ganau, Sergi</creatorcontrib><creatorcontrib>Ubeda, Belén</creatorcontrib><creatorcontrib>Bargallo, 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Nomogram</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-04-21</date><risdate>2023</risdate><volume>15</volume><issue>8</issue><spage>2392</spage><pages>2392-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) in ductal carcinoma in situ (DCIS) have been shown to reduce the risk of local recurrence. To predict the risk of ipsilateral breast tumor relapse (IBTR) after BCS, the Memorial Sloan Kettering Cancer Center (MSKCC) developed a nomogram to analyze local recurrence (LR) risk in our cohort and to assess its external validation.
A historical cohort study using data from 296 patients treated for DCIS at the Hospital Clínic of Barcelona was carried out. Patients who had had a mastectomy were excluded from the analysis.
The mean age was 58 years (42-75), and the median follow-up time was 10.64 years. The overall local relapse rate was 13.04% (27 patients) during the study period. Actuarial 5- and 10-year IBTR rates were 5.8 and 12.9%, respectively. The external validation of the MSKCC nomogram was performed using a multivariate logistic regression analysis on a total of 207 patients, which did not reach statistical significance in the studied population for predicting LR (
= 0.10). The expression of estrogen receptors was significantly associated with a decreased risk of LR (OR: 0.25;
= 0.004).
In our series, the LR rate was 13.4%, which was in accordance with the published series. The MSKCC nomogram did not accurately predict the IBTR in this Spanish cohort of patients treated for DCIS (
= 0.10).</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37190320</pmid><doi>10.3390/cancers15082392</doi><orcidid>https://orcid.org/0000-0002-6586-1712</orcidid><orcidid>https://orcid.org/0000-0002-7974-3346</orcidid><orcidid>https://orcid.org/0000-0002-1227-1137</orcidid><orcidid>https://orcid.org/0000-0001-6215-2251</orcidid><orcidid>https://orcid.org/0000-0002-9333-3642</orcidid><orcidid>https://orcid.org/0000-0001-5915-8580</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Breast cancer Cancer Cancer therapies Carcinoma, Ductal Care and treatment Decision making Endocrine therapy Estrogen receptors Estrogens Family medical history Lumpectomy Mastectomy Patient outcomes Patients Population studies Radiation therapy Regression analysis Relapse Risk factors Statistics Surgery Tumors Variables |
| title | Analysis of Local Recurrence Risk in Ductal Carcinoma In Situ and External Validation of the Memorial Sloan Kettering Cancer Center Nomogram |
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