Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?
Donor shortages have led transplant centers to extend their criteria for lung donors. Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all pat...
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| Veröffentlicht in: | Transplant international 2023-04, Vol.36, p.11071-11071 |
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| creator | Sommer, Wiebke Franz, Maximilian Aburahma, Khalil Saipbaev, Akylbek Flöthmann, Katharina Yablonski, Pavel Avsar, Murat Tudorache, Igor Greer, Mark Haverich, Axel Welte, Tobias Kuehn, Christian Salman, Jawad Warnecke, Gregor Ius, Fabio |
| description | Donor shortages have led transplant centers to extend their criteria for lung donors. Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all patients who underwent lung transplantation between 06/2010 and 12/2019 were included in the analysis, and the outcomes were compared between patients receiving organs from donors |
| doi_str_mv | 10.3389/ti.2023.11071 |
| format | Article |
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Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all patients who underwent lung transplantation between 06/2010 and 12/2019 were included in the analysis, and the outcomes were compared between patients receiving organs from donors <70 years of age and patients transplanted with lungs from donors ≥70 years of age. Among the 1,168 lung-transplanted patients, 62 patients received lungs from donors ≥70 years of age. The recipient age of those receiving older organs was significantly higher, and they were more likely to suffer from obstructive lung disease. Older donors were exposed to significantly shorter periods of mechanical ventilation prior to donation, had higher Horowitz indices, and were less likely to have smoked. The postoperative time on mechanical ventilation, time on ICU, and total hospital stay were comparable. The overall survival as well as CLAD-free survival showed no differences between both groups in the follow-up period. Utilization of lungs from donors ≥70 years of age leads to excellent mid- and long-term results that are similar to organs from younger donors when the organs from older donors are carefully preselected.</description><identifier>ISSN: 1432-2277</identifier><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.3389/ti.2023.11071</identifier><identifier>PMID: 37125386</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Age Factors ; Health Archive ; Humans ; Lung ; Lung Transplantation ; Retrospective Studies ; Tissue Donors ; Treatment Outcome</subject><ispartof>Transplant international, 2023-04, Vol.36, p.11071-11071</ispartof><rights>Copyright © 2023 Sommer, Franz, Aburahma, Saipbaev, Flöthmann, Yablonski, Avsar, Tudorache, Greer, Haverich, Welte, Kuehn, Salman, Warnecke and Ius.</rights><rights>Copyright © 2023 Sommer, Franz, Aburahma, Saipbaev, Flöthmann, Yablonski, Avsar, Tudorache, Greer, Haverich, Welte, Kuehn, Salman, Warnecke and Ius. 2023 Sommer, Franz, Aburahma, Saipbaev, Flöthmann, Yablonski, Avsar, Tudorache, Greer, Haverich, Welte, Kuehn, Salman, Warnecke and Ius</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7cd63efe59dcfa33cf77c2e4ae9d2c713497d451c4acb171de27e272784cadef3</citedby><cites>FETCH-LOGICAL-c388t-7cd63efe59dcfa33cf77c2e4ae9d2c713497d451c4acb171de27e272784cadef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37125386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sommer, Wiebke</creatorcontrib><creatorcontrib>Franz, Maximilian</creatorcontrib><creatorcontrib>Aburahma, Khalil</creatorcontrib><creatorcontrib>Saipbaev, Akylbek</creatorcontrib><creatorcontrib>Flöthmann, Katharina</creatorcontrib><creatorcontrib>Yablonski, Pavel</creatorcontrib><creatorcontrib>Avsar, Murat</creatorcontrib><creatorcontrib>Tudorache, Igor</creatorcontrib><creatorcontrib>Greer, Mark</creatorcontrib><creatorcontrib>Haverich, Axel</creatorcontrib><creatorcontrib>Welte, Tobias</creatorcontrib><creatorcontrib>Kuehn, Christian</creatorcontrib><creatorcontrib>Salman, Jawad</creatorcontrib><creatorcontrib>Warnecke, Gregor</creatorcontrib><creatorcontrib>Ius, Fabio</creatorcontrib><title>Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Donor shortages have led transplant centers to extend their criteria for lung donors. Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all patients who underwent lung transplantation between 06/2010 and 12/2019 were included in the analysis, and the outcomes were compared between patients receiving organs from donors <70 years of age and patients transplanted with lungs from donors ≥70 years of age. Among the 1,168 lung-transplanted patients, 62 patients received lungs from donors ≥70 years of age. The recipient age of those receiving older organs was significantly higher, and they were more likely to suffer from obstructive lung disease. Older donors were exposed to significantly shorter periods of mechanical ventilation prior to donation, had higher Horowitz indices, and were less likely to have smoked. The postoperative time on mechanical ventilation, time on ICU, and total hospital stay were comparable. The overall survival as well as CLAD-free survival showed no differences between both groups in the follow-up period. Utilization of lungs from donors ≥70 years of age leads to excellent mid- and long-term results that are similar to organs from younger donors when the organs from older donors are carefully preselected.</description><subject>Age Factors</subject><subject>Health Archive</subject><subject>Humans</subject><subject>Lung</subject><subject>Lung Transplantation</subject><subject>Retrospective Studies</subject><subject>Tissue Donors</subject><subject>Treatment Outcome</subject><issn>1432-2277</issn><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtOwzAQhi0E4lFYskVesknxI6mTFUKU8lAlNumCleU642LUxMV2kHoEbsGGi3AUTkIKpQJppJnRfPpnRj9Cx5T0Oc-Ls2j7jDDep5QIuoX2acpZwpgQ23_qPXQQwhMhhOUZ2UV7XFCW8Xywj6bjtpkFPPKuxkPXOB_w5-u7IB9vD6C6xhl8MQNsnMelV01YzFUTVbSuSYYOj10zS0rwNb5vo3Y1BHzXhmjNEpePYD2eBDg_RDtGzQMcrXMPTUZX5eVNMr6_vr28GCea53lMhK4GHAxkRaWN4lwbITSDVEFRMS0oTwtRpRnVqdJTKmgFTHTBRJ5qVYHhPXT-o7topzVUGpro1VwuvK2VX0qnrPw_aeyjnLkXSQnlPM0GncLpWsG75xZClLUNGubdz-DaIFlOckYzNig6NPlBtXcheDCbPZTIlTEyWrkyRn4b0_Enf4_b0L9O8C-rEoxM</recordid><startdate>20230413</startdate><enddate>20230413</enddate><creator>Sommer, Wiebke</creator><creator>Franz, Maximilian</creator><creator>Aburahma, Khalil</creator><creator>Saipbaev, Akylbek</creator><creator>Flöthmann, Katharina</creator><creator>Yablonski, Pavel</creator><creator>Avsar, Murat</creator><creator>Tudorache, Igor</creator><creator>Greer, Mark</creator><creator>Haverich, Axel</creator><creator>Welte, Tobias</creator><creator>Kuehn, Christian</creator><creator>Salman, Jawad</creator><creator>Warnecke, Gregor</creator><creator>Ius, Fabio</creator><general>Frontiers Media S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230413</creationdate><title>Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?</title><author>Sommer, Wiebke ; 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Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all patients who underwent lung transplantation between 06/2010 and 12/2019 were included in the analysis, and the outcomes were compared between patients receiving organs from donors <70 years of age and patients transplanted with lungs from donors ≥70 years of age. Among the 1,168 lung-transplanted patients, 62 patients received lungs from donors ≥70 years of age. The recipient age of those receiving older organs was significantly higher, and they were more likely to suffer from obstructive lung disease. Older donors were exposed to significantly shorter periods of mechanical ventilation prior to donation, had higher Horowitz indices, and were less likely to have smoked. The postoperative time on mechanical ventilation, time on ICU, and total hospital stay were comparable. The overall survival as well as CLAD-free survival showed no differences between both groups in the follow-up period. Utilization of lungs from donors ≥70 years of age leads to excellent mid- and long-term results that are similar to organs from younger donors when the organs from older donors are carefully preselected.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>37125386</pmid><doi>10.3389/ti.2023.11071</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Transplant international, 2023-04, Vol.36, p.11071-11071 |
| issn | 1432-2277 0934-0874 1432-2277 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Factors Health Archive Humans Lung Lung Transplantation Retrospective Studies Tissue Donors Treatment Outcome |
| title | Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use? |
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