Oxidative DNA Damage by N4-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir

Abstract Molnupiravir is an antiviral agent recently used for treating coronavirus disease 2019 (COVID-19). Here, we demonstrate that N4-hydroxycytidine (NHC), a molnupiravir metabolite, treated with cytidine deaminase (CDA) induced Cu(II)-mediated oxidative DNA damage in isolated DNA. A colorimetri...

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Veröffentlicht in:	The Journal of infectious diseases 2023-04, Vol.227 (9), p.1068-1072
Hauptverfasser:	Kobayashi, Hatasu, Mori, Yurie, Ahmed, Sharif, Hirao, Yuichiro, Kato, Shinya, Kawanishi, Shosuke, Murata, Mariko, Oikawa, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Brief Report Colorimetry Coronaviruses COVID-19 Cytidine deaminase DNA Damage Humans Hydrogen Peroxide Hydroxylamine Hydroxylamines - pharmacology Oxidative Stress Risk assessment SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral diseases
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