An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice

Chronic alcohol feeding increases the levels of 2-arachidonoylglycerol (2-AG) in the liver, which activates hepatic cannabinoid receptor type 1 (CB1R), leading to oxidative liver injury. 2-AG biosynthesis is catalyzed by diacylglycerol lipase (DAGL). However, the mechanisms regulating hepatic DAGL g...

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Veröffentlicht in:	Archives of toxicology 2020-02, Vol.94 (2), p.427-438
Hauptverfasser:	Jung, Yoon Seok, Kim, Yong-Hoon, Radhakrishnan, Kamalakannan, kim, Jina, Kim, Don-Kyu, Lee, Ji-Hyeok, Oh, Hyunhee, Lee, In-Kyu, Kim, Wook, Cho, Sung Jin, Choi, Cheol Soo, Dooley, Steven, Egan, Josephine M., Lee, Chul-Ho, Choi, Hueng-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Alcohol Alcohols Animals Arachidonic Acids - biosynthesis Arachidonic Acids - pharmacology Biomedical and Life Sciences Biomedicine Biosynthesis Calories Cannabinoid CB1 receptors Cannabinoids Diglycerides Endocannabinoids - biosynthesis Environmental Health Estrogens Ethanol - toxicity Fatty liver Gene expression Gene Expression Regulation - drug effects Glycerides - biosynthesis Hep G2 Cells Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Humans Inverse agonists Lipase Lipoprotein lipase Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Liver Liver - drug effects Liver - metabolism Liver diseases Male Medical treatment Mice, Inbred C57BL Mice, Knockout Molecular Toxicology Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Steatosis Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Transcription
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