Long-term proliferation of immature hypoxia-dependent JMML cells supported by a 3D in vitro system

•A defined 3D in vitro model, under hypoxic condition, sustains long-term propagation of JMML cells with specific hallmarks.•In vitro low oxygen levels drive a metabolic switch that redirect JMML cells toward self-renewal. [Display omitted] Juvenile myelomonocytic leukemia (JMML) is a rare clonal st...

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Veröffentlicht in:	Blood advances 2023-04, Vol.7 (8), p.1513-1524
Hauptverfasser:	Cani, Alice, Tretti Parenzan, Caterina, Frasson, Chiara, Rampazzo, Elena, Scarparo, Pamela, Francescato, Samuela, Caicci, Federico, Barbieri, Vito, Rosato, Antonio, Cesaro, Simone, Zecca, Marco, Micalizzi, Concetta, Sainati, Laura, Pigazzi, Martina, Biffi, Alessandra, Buldini, Barbara, Locatelli, Franco, Persano, Luca, Masetti, Riccardo, te Kronnie, Geertruij, Bresolin, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow Cell Proliferation Child, Preschool Granulocytes Humans Leukemia, Myelomonocytic, Juvenile - therapy Myeloid Neoplasia
Online-Zugang:	Volltext
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