Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy
Cardiac amyloidosis (CA), following a non-invasive diagnosis, constitutes an increasingly prevalent heart failure (HF) etiology. This study aims to determine which echocardiography findings help to diagnose CA in patients with left ventricular hypertrophy (LVH) admitted for decompensated HF. The pre...
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| Veröffentlicht in: | Cardiology journal 2023-04, Vol.30 (2), p.266-275 |
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| creator | Melero Polo, Jorge Roteta Unceta-Barrenechea, Ana Revilla Martí, Pablo Pérez-Palacios, Raquel Gracia Gutiérrez, Anyuli Bueno Juana, Esperanza Andrés Gracia, Alejandro Atienza Ayala, Saida Aibar Arregui, Miguel Ángel |
| description | Cardiac amyloidosis (CA), following a non-invasive diagnosis, constitutes an increasingly prevalent heart failure (HF) etiology. This study aims to determine which echocardiography findings help to diagnose CA in patients with left ventricular hypertrophy (LVH) admitted for decompensated HF.
The present study is a retrospective observational study on a cohort of 85 LVH patients admitted for HF decompensation, in which 99mTc-DPD scanning was performed to rule out transthyretin CA. The echocardiographic findings obtained were compared between CA and non-CA groups.
From a total number of 85 patients, 49 (57.6%) met the CA criteria and 36 (42.3%) were ruled out for the disease. Interventricular septum thickness (16 ± 3 mm vs. 14 ± 3 mm), left ventricular posterior wall thickness (14 ± 3 mm vs. 11 ± 2 mm), left ventricular mass (259 ± 76 g vs. 224 ± 53 g), left ventricular end-diastolic diameter (48 ± 7 mm vs. 53 ± 6 mm), left ventricular end-diastolic indexed volume (51 ± 18 cm3/m2 vs. 59 ± 16 cm3/m2), tricuspid annular plane systolic excursion (16 ± 5 mm vs. 20 ± 4 mm), right atrial area (27.4 ± 8.4 cm2 vs. 22.2 ± 5.7 cm2) and strain relative apical sparing (2.2 ± 0.9 vs. 1.03 ± 0.4; p = 0.04) were significantly associated with the diagnosis of CA.
In patients with LVH admitted for HF decompensation, there are several echocardiographic features (LVH, reduced left ventricular cavity size, strain relative apical sparing, right atrial dilation, and altered right ventricular function) that are associated with the diagnosis of cardiac amyloidosis. |
| doi_str_mv | 10.5603/CJ.a2021.0085 |
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The present study is a retrospective observational study on a cohort of 85 LVH patients admitted for HF decompensation, in which 99mTc-DPD scanning was performed to rule out transthyretin CA. The echocardiographic findings obtained were compared between CA and non-CA groups.
From a total number of 85 patients, 49 (57.6%) met the CA criteria and 36 (42.3%) were ruled out for the disease. Interventricular septum thickness (16 ± 3 mm vs. 14 ± 3 mm), left ventricular posterior wall thickness (14 ± 3 mm vs. 11 ± 2 mm), left ventricular mass (259 ± 76 g vs. 224 ± 53 g), left ventricular end-diastolic diameter (48 ± 7 mm vs. 53 ± 6 mm), left ventricular end-diastolic indexed volume (51 ± 18 cm3/m2 vs. 59 ± 16 cm3/m2), tricuspid annular plane systolic excursion (16 ± 5 mm vs. 20 ± 4 mm), right atrial area (27.4 ± 8.4 cm2 vs. 22.2 ± 5.7 cm2) and strain relative apical sparing (2.2 ± 0.9 vs. 1.03 ± 0.4; p = 0.04) were significantly associated with the diagnosis of CA.
In patients with LVH admitted for HF decompensation, there are several echocardiographic features (LVH, reduced left ventricular cavity size, strain relative apical sparing, right atrial dilation, and altered right ventricular function) that are associated with the diagnosis of cardiac amyloidosis.</description><identifier>ISSN: 1897-5593</identifier><identifier>EISSN: 1898-018X</identifier><identifier>DOI: 10.5603/CJ.a2021.0085</identifier><identifier>PMID: 34355777</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Amyloidosis ; Amyloidosis - diagnosis ; Amyloidosis - diagnostic imaging ; Atrial Fibrillation - complications ; Biopsy ; Cardiology ; Clinical Cardiology ; Echocardiography ; Heart failure ; Heart Failure - diagnostic imaging ; Heart Failure - etiology ; Histology ; Hospitalization ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - etiology ; Patients ; Proteins ; Ultrasonic imaging</subject><ispartof>Cardiology journal, 2023-04, Vol.30 (2), p.266-275</ispartof><rights>2023. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023 Via Medica 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-44803e3774a8b666bf93ab9721151385d338be9835a494b96f3d346665be4e693</citedby><orcidid>0000-0002-8405-4721</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129250/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129250/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34355777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melero Polo, Jorge</creatorcontrib><creatorcontrib>Roteta Unceta-Barrenechea, Ana</creatorcontrib><creatorcontrib>Revilla Martí, Pablo</creatorcontrib><creatorcontrib>Pérez-Palacios, Raquel</creatorcontrib><creatorcontrib>Gracia Gutiérrez, Anyuli</creatorcontrib><creatorcontrib>Bueno Juana, Esperanza</creatorcontrib><creatorcontrib>Andrés Gracia, Alejandro</creatorcontrib><creatorcontrib>Atienza Ayala, Saida</creatorcontrib><creatorcontrib>Aibar Arregui, Miguel Ángel</creatorcontrib><title>Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy</title><title>Cardiology journal</title><addtitle>Cardiol J</addtitle><description>Cardiac amyloidosis (CA), following a non-invasive diagnosis, constitutes an increasingly prevalent heart failure (HF) etiology. This study aims to determine which echocardiography findings help to diagnose CA in patients with left ventricular hypertrophy (LVH) admitted for decompensated HF.
The present study is a retrospective observational study on a cohort of 85 LVH patients admitted for HF decompensation, in which 99mTc-DPD scanning was performed to rule out transthyretin CA. The echocardiographic findings obtained were compared between CA and non-CA groups.
From a total number of 85 patients, 49 (57.6%) met the CA criteria and 36 (42.3%) were ruled out for the disease. Interventricular septum thickness (16 ± 3 mm vs. 14 ± 3 mm), left ventricular posterior wall thickness (14 ± 3 mm vs. 11 ± 2 mm), left ventricular mass (259 ± 76 g vs. 224 ± 53 g), left ventricular end-diastolic diameter (48 ± 7 mm vs. 53 ± 6 mm), left ventricular end-diastolic indexed volume (51 ± 18 cm3/m2 vs. 59 ± 16 cm3/m2), tricuspid annular plane systolic excursion (16 ± 5 mm vs. 20 ± 4 mm), right atrial area (27.4 ± 8.4 cm2 vs. 22.2 ± 5.7 cm2) and strain relative apical sparing (2.2 ± 0.9 vs. 1.03 ± 0.4; p = 0.04) were significantly associated with the diagnosis of CA.
In patients with LVH admitted for HF decompensation, there are several echocardiographic features (LVH, reduced left ventricular cavity size, strain relative apical sparing, right atrial dilation, and altered right ventricular function) that are associated with the diagnosis of cardiac amyloidosis.</description><subject>Amyloidosis</subject><subject>Amyloidosis - diagnosis</subject><subject>Amyloidosis - diagnostic imaging</subject><subject>Atrial Fibrillation - complications</subject><subject>Biopsy</subject><subject>Cardiology</subject><subject>Clinical Cardiology</subject><subject>Echocardiography</subject><subject>Heart failure</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - etiology</subject><subject>Histology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Patients</subject><subject>Proteins</subject><subject>Ultrasonic imaging</subject><issn>1897-5593</issn><issn>1898-018X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUtr3DAUhUVoyatdZlsE3XTjqd6WVqUMeRLopoXuxLUsx0o8livZKfPvq5k8aLu6F-7H4Zx7EDqjZCUV4Z_XNytghNEVIVoeoGOqja4I1T_f7Pe6ktLwI3SS8z0hykjJDtERF1zKuq6P0XTu-uggtSHeJZj64PAG0oNPGccO7w_gMGy2QwxtzCHjMOIJ5uDHOePfYe5x7yHNuIMwLMljGFs8-G7Gj4VIwS0DJNxvJ5_mFKd--w697WDI_v3zPEU_Ls6_r6-q22-X1-uvt5UTVM2VEJpwz-tagG6UUk1nODSmZpRKyrVsOdeNN5pLEEY0RnW85aKAsvHCK8NP0Zcn3WlpNr51Ozcw2CmFkm9rIwT772UMvb2Lj5YSygyTpCh8elZI8dfi82w3ITs_DDD6uGTLymcFN4zpgn78D72PSxpLPstKDs2VZjtL1RPlUsw5-e7VDSV2V6Zd39h9mXZXZuE__B3hlX5pj_8Bc4mcDQ</recordid><startdate>20230417</startdate><enddate>20230417</enddate><creator>Melero Polo, Jorge</creator><creator>Roteta Unceta-Barrenechea, Ana</creator><creator>Revilla Martí, Pablo</creator><creator>Pérez-Palacios, Raquel</creator><creator>Gracia Gutiérrez, Anyuli</creator><creator>Bueno Juana, Esperanza</creator><creator>Andrés Gracia, Alejandro</creator><creator>Atienza Ayala, Saida</creator><creator>Aibar Arregui, Miguel Ángel</creator><general>Wydawnictwo Via Medica</general><general>Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8405-4721</orcidid></search><sort><creationdate>20230417</creationdate><title>Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy</title><author>Melero Polo, Jorge ; Roteta Unceta-Barrenechea, Ana ; Revilla Martí, Pablo ; Pérez-Palacios, Raquel ; Gracia Gutiérrez, Anyuli ; Bueno Juana, Esperanza ; Andrés Gracia, Alejandro ; Atienza Ayala, Saida ; Aibar Arregui, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-44803e3774a8b666bf93ab9721151385d338be9835a494b96f3d346665be4e693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amyloidosis</topic><topic>Amyloidosis - diagnosis</topic><topic>Amyloidosis - diagnostic imaging</topic><topic>Atrial Fibrillation - complications</topic><topic>Biopsy</topic><topic>Cardiology</topic><topic>Clinical Cardiology</topic><topic>Echocardiography</topic><topic>Heart failure</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - etiology</topic><topic>Histology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Patients</topic><topic>Proteins</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melero Polo, Jorge</creatorcontrib><creatorcontrib>Roteta Unceta-Barrenechea, Ana</creatorcontrib><creatorcontrib>Revilla Martí, Pablo</creatorcontrib><creatorcontrib>Pérez-Palacios, Raquel</creatorcontrib><creatorcontrib>Gracia Gutiérrez, Anyuli</creatorcontrib><creatorcontrib>Bueno Juana, Esperanza</creatorcontrib><creatorcontrib>Andrés Gracia, Alejandro</creatorcontrib><creatorcontrib>Atienza Ayala, Saida</creatorcontrib><creatorcontrib>Aibar Arregui, Miguel Ángel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melero Polo, Jorge</au><au>Roteta Unceta-Barrenechea, Ana</au><au>Revilla Martí, Pablo</au><au>Pérez-Palacios, Raquel</au><au>Gracia Gutiérrez, Anyuli</au><au>Bueno Juana, Esperanza</au><au>Andrés Gracia, Alejandro</au><au>Atienza Ayala, Saida</au><au>Aibar Arregui, Miguel Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy</atitle><jtitle>Cardiology journal</jtitle><addtitle>Cardiol J</addtitle><date>2023-04-17</date><risdate>2023</risdate><volume>30</volume><issue>2</issue><spage>266</spage><epage>275</epage><pages>266-275</pages><issn>1897-5593</issn><eissn>1898-018X</eissn><abstract>Cardiac amyloidosis (CA), following a non-invasive diagnosis, constitutes an increasingly prevalent heart failure (HF) etiology. This study aims to determine which echocardiography findings help to diagnose CA in patients with left ventricular hypertrophy (LVH) admitted for decompensated HF.
The present study is a retrospective observational study on a cohort of 85 LVH patients admitted for HF decompensation, in which 99mTc-DPD scanning was performed to rule out transthyretin CA. The echocardiographic findings obtained were compared between CA and non-CA groups.
From a total number of 85 patients, 49 (57.6%) met the CA criteria and 36 (42.3%) were ruled out for the disease. Interventricular septum thickness (16 ± 3 mm vs. 14 ± 3 mm), left ventricular posterior wall thickness (14 ± 3 mm vs. 11 ± 2 mm), left ventricular mass (259 ± 76 g vs. 224 ± 53 g), left ventricular end-diastolic diameter (48 ± 7 mm vs. 53 ± 6 mm), left ventricular end-diastolic indexed volume (51 ± 18 cm3/m2 vs. 59 ± 16 cm3/m2), tricuspid annular plane systolic excursion (16 ± 5 mm vs. 20 ± 4 mm), right atrial area (27.4 ± 8.4 cm2 vs. 22.2 ± 5.7 cm2) and strain relative apical sparing (2.2 ± 0.9 vs. 1.03 ± 0.4; p = 0.04) were significantly associated with the diagnosis of CA.
In patients with LVH admitted for HF decompensation, there are several echocardiographic features (LVH, reduced left ventricular cavity size, strain relative apical sparing, right atrial dilation, and altered right ventricular function) that are associated with the diagnosis of cardiac amyloidosis.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>34355777</pmid><doi>10.5603/CJ.a2021.0085</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8405-4721</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amyloidosis Amyloidosis - diagnosis Amyloidosis - diagnostic imaging Atrial Fibrillation - complications Biopsy Cardiology Clinical Cardiology Echocardiography Heart failure Heart Failure - diagnostic imaging Heart Failure - etiology Histology Hospitalization Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Patients Proteins Ultrasonic imaging |
| title | Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy |
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