Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ‐1

DJ‐1, a protein encoded by PARK7 plays a protective role against neurodegeneration. Since its glyoxalase III activity catalyzing methylglyoxal (MG) to lactate was discovered, DJ‐1 has been re‐established as a deglycase decomposing the MG‐intermediates with amino acids and nucleotides (hemithioacetal...

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Veröffentlicht in:	Protein science 2023-05, Vol.32 (5), p.e4641-n/a
Hauptverfasser:	Choi, Joonhyeok, Tak, Sungho, Jung, Hoe‐Myung, Cha, Soyoung, Hwang, Eunha, Lee, Donghan, Lee, Joon‐Hwa, Ryu, Kyoung‐Seok, Park, Chankyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidoreductases Amino acids Carbonyl compounds Carbonyls Deglycase DJ‐1 glyoxalase III Humans Intermediates ITC Lactic acid Lactic Acid - metabolism methylglyoxal Neurodegeneration NMR Nuclear magnetic resonance Nucleotides PARK7 protein Parkinson Disease - metabolism Perturbation Protein Deglycase DJ-1 - genetics Protein Deglycase DJ-1 - metabolism Pyruvaldehyde Pyruvaldehyde - chemistry Pyruvaldehyde - metabolism reactive carbonyl species
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