Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions
In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challe...
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| Veröffentlicht in: | Pigment cell and melanoma research 2020-07, Vol.33 (4), p.527-541 |
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| creator | Glitza, Isabella C. Smalley, Keiran S. M. Brastianos, Priscilla K. Davies, Michael A. McCutcheon, Ian Liu, James K. C. Ahmed, Kamran A. Arrington, John A. Evernden, Brittany R. Smalley, Inna Eroglu, Zeynep Khushalani, Nikhil Margolin, Kim Kluger, Harriet Atkins, Michael B. Tawbi, Hussein Boire, Adrienne Forsyth, Peter |
| description | In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease. |
| doi_str_mv | 10.1111/pcmr.12861 |
| format | Article |
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M. ; Brastianos, Priscilla K. ; Davies, Michael A. ; McCutcheon, Ian ; Liu, James K. C. ; Ahmed, Kamran A. ; Arrington, John A. ; Evernden, Brittany R. ; Smalley, Inna ; Eroglu, Zeynep ; Khushalani, Nikhil ; Margolin, Kim ; Kluger, Harriet ; Atkins, Michael B. ; Tawbi, Hussein ; Boire, Adrienne ; Forsyth, Peter</creator><creatorcontrib>Glitza, Isabella C. ; Smalley, Keiran S. M. ; Brastianos, Priscilla K. ; Davies, Michael A. ; McCutcheon, Ian ; Liu, James K. C. ; Ahmed, Kamran A. ; Arrington, John A. ; Evernden, Brittany R. ; Smalley, Inna ; Eroglu, Zeynep ; Khushalani, Nikhil ; Margolin, Kim ; Kluger, Harriet ; Atkins, Michael B. ; Tawbi, Hussein ; Boire, Adrienne ; Forsyth, Peter</creatorcontrib><description>In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease.</description><identifier>ISSN: 1755-1471</identifier><identifier>ISSN: 1755-148X</identifier><identifier>EISSN: 1755-148X</identifier><identifier>DOI: 10.1111/pcmr.12861</identifier><identifier>PMID: 31916400</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Brain cancer ; Cell-Free Nucleic Acids - metabolism ; Central nervous system ; Clinical Trials as Topic ; Humans ; intrathecal therapy ; leptomeningeal carcinomatosis ; leptomeningeal disease ; Melanoma ; Melanoma - complications ; Meningeal Neoplasms - complications ; Meningeal Neoplasms - diagnosis ; Meningeal Neoplasms - epidemiology ; Meningeal Neoplasms - therapy ; Meninges ; Metastases ; Metastasis ; Molecular Targeted Therapy ; Neoplastic Cells, Circulating - pathology ; neoplastic meningitis ; Patients</subject><ispartof>Pigment cell and melanoma research, 2020-07, Vol.33 (4), p.527-541</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. 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M.</creatorcontrib><creatorcontrib>Brastianos, Priscilla K.</creatorcontrib><creatorcontrib>Davies, Michael A.</creatorcontrib><creatorcontrib>McCutcheon, Ian</creatorcontrib><creatorcontrib>Liu, James K. C.</creatorcontrib><creatorcontrib>Ahmed, Kamran A.</creatorcontrib><creatorcontrib>Arrington, John A.</creatorcontrib><creatorcontrib>Evernden, Brittany R.</creatorcontrib><creatorcontrib>Smalley, Inna</creatorcontrib><creatorcontrib>Eroglu, Zeynep</creatorcontrib><creatorcontrib>Khushalani, Nikhil</creatorcontrib><creatorcontrib>Margolin, Kim</creatorcontrib><creatorcontrib>Kluger, Harriet</creatorcontrib><creatorcontrib>Atkins, Michael B.</creatorcontrib><creatorcontrib>Tawbi, Hussein</creatorcontrib><creatorcontrib>Boire, Adrienne</creatorcontrib><creatorcontrib>Forsyth, Peter</creatorcontrib><title>Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions</title><title>Pigment cell and melanoma research</title><addtitle>Pigment Cell Melanoma Res</addtitle><description>In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. 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| ispartof | Pigment cell and melanoma research, 2020-07, Vol.33 (4), p.527-541 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Brain cancer Cell-Free Nucleic Acids - metabolism Central nervous system Clinical Trials as Topic Humans intrathecal therapy leptomeningeal carcinomatosis leptomeningeal disease Melanoma Melanoma - complications Meningeal Neoplasms - complications Meningeal Neoplasms - diagnosis Meningeal Neoplasms - epidemiology Meningeal Neoplasms - therapy Meninges Metastases Metastasis Molecular Targeted Therapy Neoplastic Cells, Circulating - pathology neoplastic meningitis Patients |
| title | Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions |
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