IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome

Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their pathogenesis is poorly understood. IL11 (interleukin-11) causes aortic disease in a mouse model of MFS and was studied here in the lung...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-05, Vol.43 (5), p.739-754
Hauptverfasser:	Ng, Benjamin, Xie, Chen, Su, Liping, Kuthubudeen, Fathima F., Kwek, Xiu-Yi, Yeong, Daryl, Pua, Chee Jian, Cook, Stuart A., Lim, Wei-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Sciences Disease Models, Animal Endothelial Cells - metabolism Fibrillin-1 - genetics Interleukin-11 - genetics Interleukin-11 Receptor alpha Subunit Marfan Syndrome - complications Marfan Syndrome - genetics Marfan Syndrome - pathology Matrix Metalloproteinase 2 - genetics Mice Mice, Knockout Pulmonary Emphysema - complications Pulmonary Emphysema - genetics
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