Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats
In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation exposure to MWNT-7, a type of MWCNTs, and ITO induced lung carcinogenicity in both male and female rats. Toxicity to...
Gespeichert in:
| Veröffentlicht in: | Journal of Toxicologic Pathology 2022, pp.2022-0086 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 83 |
|---|---|
| container_issue | 2 |
| container_start_page | 2022-0086 |
| container_title | Journal of Toxicologic Pathology |
| container_volume | 36 |
| creator | FUKUSHIMA, Shoji KASAI, Tatsuya SENOH, Hideki UMEDA, Yumi MINE, Takashi SASAKI, Toshiaki KONDO, Hitomi MATSUMOTO, Michiharu AISO, Shigetoshi |
| description | In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation exposure to MWNT-7, a type of MWCNTs, and ITO induced lung carcinogenicity in both male and female rats. Toxicity to the alveolar epithelium is induced by macrophages undergoing frustrated phagocytosis or frustrated degradation of engulfed particles (referred to as frustrated macrophages). Melted macrophage contents contribute significantly to development of hyperplasia of the alveolar epithelium, which eventually results in the induction of lung carcinoma. MWNT-7 and ITO induce secondary genotoxicity; consequently, a no-observed-adverse-effect level can be applied to these materials rather than benchmark doses that are used for non-threshold carcinogens. Thus, establishing occupational exposure limit values for MWNT-7 and ITO based on the existence of a carcinogenic threshold is reasonable. |
| doi_str_mv | 10.1293/tox.2022-0086 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10123297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2806994239</sourcerecordid><originalsourceid>FETCH-LOGICAL-c722t-693fb2bf81afc44d434d9206bd0c4c009aa938e76f07c2556d80177c23aa1aa53</originalsourceid><addsrcrecordid>eNpdkruPEzEQxi0E4kKgpEUr0dDs4ce-TINQBAfiJBqQ6KxZrzdxtLGD7T2Rlr-c8eVueRSWx55Pv5nxZ0KeM3rJuBSvk_95ySnnJaVd84CsWNexUrL6-0OyopJVGMvugjyJcU8pb2ktHpML0TLKZMNW5NfGuxRsPyfrXeHHAnlW-8lvrYapOELa5cMJ7wuv9YwXKMTMzsCUdm-KaXbbQkPQ1vmtcVbbdMqc0fbBz7EANyAlJKvnCZIp4tzHBE6bWFhXBEjxKXk0whTNs7t9Tb59eP9187G8_nL1afPuutQt56lspBh73o8dg1FX1VCJapCcNv1AdaUplQBSdKZtRtpqXtfN0FHWYigAGEAt1uTtmXuc-4MZtMHBYVLHYA8QTsqDVf9mnN2prb9R-FZccNki4dUdIfgfs4lJHWzUZprAGZxV8Y42UlZcSJS-_E-693PAh8sq0fK6pbivSXlW6eBjDGZcumFUZXsV2qGyvSrbi_oXf4-wqO_9RMHVWYDZbKB3k3XmT-1hEEg8QmYKZIqGZnRejcw1RIUfSLS5tc9n0h7t2pql1K2Vk7ltDIYbbETR-2BpdFHpHQRlnPgNXaTXJA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2837257028</pqid></control><display><type>article</type><title>Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats</title><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>FUKUSHIMA, Shoji ; KASAI, Tatsuya ; SENOH, Hideki ; UMEDA, Yumi ; MINE, Takashi ; SASAKI, Toshiaki ; KONDO, Hitomi ; MATSUMOTO, Michiharu ; AISO, Shigetoshi</creator><creatorcontrib>FUKUSHIMA, Shoji ; KASAI, Tatsuya ; SENOH, Hideki ; UMEDA, Yumi ; MINE, Takashi ; SASAKI, Toshiaki ; KONDO, Hitomi ; MATSUMOTO, Michiharu ; AISO, Shigetoshi ; Japan Bioassay Research Center (JBRC ; Japan Organization of Occupational Health and Safety ; Association for Promotion of Research on Risk Assessment</creatorcontrib><description>In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation exposure to MWNT-7, a type of MWCNTs, and ITO induced lung carcinogenicity in both male and female rats. Toxicity to the alveolar epithelium is induced by macrophages undergoing frustrated phagocytosis or frustrated degradation of engulfed particles (referred to as frustrated macrophages). Melted macrophage contents contribute significantly to development of hyperplasia of the alveolar epithelium, which eventually results in the induction of lung carcinoma. MWNT-7 and ITO induce secondary genotoxicity; consequently, a no-observed-adverse-effect level can be applied to these materials rather than benchmark doses that are used for non-threshold carcinogens. Thus, establishing occupational exposure limit values for MWNT-7 and ITO based on the existence of a carcinogenic threshold is reasonable.</description><identifier>ISSN: 0914-9198</identifier><identifier>EISSN: 1881-915X</identifier><identifier>EISSN: 1347-7404</identifier><identifier>DOI: 10.1293/tox.2022-0086</identifier><identifier>PMID: 37101961</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</publisher><subject>Alveoli ; Carcinogenicity ; Carcinogens ; Epithelium ; Exposure ; Exposure limits ; Genotoxicity ; Hyperplasia ; indium tin oxide ; Indium tin oxides ; Inhalation ; Invited Review ; Lung carcinoma ; Lungs ; Macrophages ; Multi wall carbon nanotubes ; multi-walled carbon nanotube ; Occupational exposure ; occupational exposure limit values ; Occupational health ; phagocytic macrophage ; Phagocytosis ; rat pulmonary carcinogenicity ; Respiration ; Toxicity</subject><ispartof>Journal of Toxicologic Pathology, 2022, pp.2022-0086</ispartof><rights>2022 The Japanese Society of Toxicologic Pathology</rights><rights>2023 The Japanese Society of Toxicologic Pathology.</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>2023 The Japanese Society of Toxicologic Pathology 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c722t-693fb2bf81afc44d434d9206bd0c4c009aa938e76f07c2556d80177c23aa1aa53</citedby><cites>FETCH-LOGICAL-c722t-693fb2bf81afc44d434d9206bd0c4c009aa938e76f07c2556d80177c23aa1aa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123297/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123297/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37101961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUKUSHIMA, Shoji</creatorcontrib><creatorcontrib>KASAI, Tatsuya</creatorcontrib><creatorcontrib>SENOH, Hideki</creatorcontrib><creatorcontrib>UMEDA, Yumi</creatorcontrib><creatorcontrib>MINE, Takashi</creatorcontrib><creatorcontrib>SASAKI, Toshiaki</creatorcontrib><creatorcontrib>KONDO, Hitomi</creatorcontrib><creatorcontrib>MATSUMOTO, Michiharu</creatorcontrib><creatorcontrib>AISO, Shigetoshi</creatorcontrib><creatorcontrib>Japan Bioassay Research Center (JBRC</creatorcontrib><creatorcontrib>Japan Organization of Occupational Health and Safety</creatorcontrib><creatorcontrib>Association for Promotion of Research on Risk Assessment</creatorcontrib><title>Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats</title><title>Journal of Toxicologic Pathology</title><addtitle>J Toxicol Pathol</addtitle><description>In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation exposure to MWNT-7, a type of MWCNTs, and ITO induced lung carcinogenicity in both male and female rats. Toxicity to the alveolar epithelium is induced by macrophages undergoing frustrated phagocytosis or frustrated degradation of engulfed particles (referred to as frustrated macrophages). Melted macrophage contents contribute significantly to development of hyperplasia of the alveolar epithelium, which eventually results in the induction of lung carcinoma. MWNT-7 and ITO induce secondary genotoxicity; consequently, a no-observed-adverse-effect level can be applied to these materials rather than benchmark doses that are used for non-threshold carcinogens. Thus, establishing occupational exposure limit values for MWNT-7 and ITO based on the existence of a carcinogenic threshold is reasonable.</description><subject>Alveoli</subject><subject>Carcinogenicity</subject><subject>Carcinogens</subject><subject>Epithelium</subject><subject>Exposure</subject><subject>Exposure limits</subject><subject>Genotoxicity</subject><subject>Hyperplasia</subject><subject>indium tin oxide</subject><subject>Indium tin oxides</subject><subject>Inhalation</subject><subject>Invited Review</subject><subject>Lung carcinoma</subject><subject>Lungs</subject><subject>Macrophages</subject><subject>Multi wall carbon nanotubes</subject><subject>multi-walled carbon nanotube</subject><subject>Occupational exposure</subject><subject>occupational exposure limit values</subject><subject>Occupational health</subject><subject>phagocytic macrophage</subject><subject>Phagocytosis</subject><subject>rat pulmonary carcinogenicity</subject><subject>Respiration</subject><subject>Toxicity</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkruPEzEQxi0E4kKgpEUr0dDs4ce-TINQBAfiJBqQ6KxZrzdxtLGD7T2Rlr-c8eVueRSWx55Pv5nxZ0KeM3rJuBSvk_95ySnnJaVd84CsWNexUrL6-0OyopJVGMvugjyJcU8pb2ktHpML0TLKZMNW5NfGuxRsPyfrXeHHAnlW-8lvrYapOELa5cMJ7wuv9YwXKMTMzsCUdm-KaXbbQkPQ1vmtcVbbdMqc0fbBz7EANyAlJKvnCZIp4tzHBE6bWFhXBEjxKXk0whTNs7t9Tb59eP9187G8_nL1afPuutQt56lspBh73o8dg1FX1VCJapCcNv1AdaUplQBSdKZtRtpqXtfN0FHWYigAGEAt1uTtmXuc-4MZtMHBYVLHYA8QTsqDVf9mnN2prb9R-FZccNki4dUdIfgfs4lJHWzUZprAGZxV8Y42UlZcSJS-_E-693PAh8sq0fK6pbivSXlW6eBjDGZcumFUZXsV2qGyvSrbi_oXf4-wqO_9RMHVWYDZbKB3k3XmT-1hEEg8QmYKZIqGZnRejcw1RIUfSLS5tc9n0h7t2pql1K2Vk7ltDIYbbETR-2BpdFHpHQRlnPgNXaTXJA</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>FUKUSHIMA, Shoji</creator><creator>KASAI, Tatsuya</creator><creator>SENOH, Hideki</creator><creator>UMEDA, Yumi</creator><creator>MINE, Takashi</creator><creator>SASAKI, Toshiaki</creator><creator>KONDO, Hitomi</creator><creator>MATSUMOTO, Michiharu</creator><creator>AISO, Shigetoshi</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>The Japanese Society of Toxicologic Pathology</general><general>Japan Science and Technology Agency</general><general>Japanese Society of Toxicologic Pathology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats</title><author>FUKUSHIMA, Shoji ; KASAI, Tatsuya ; SENOH, Hideki ; UMEDA, Yumi ; MINE, Takashi ; SASAKI, Toshiaki ; KONDO, Hitomi ; MATSUMOTO, Michiharu ; AISO, Shigetoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c722t-693fb2bf81afc44d434d9206bd0c4c009aa938e76f07c2556d80177c23aa1aa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alveoli</topic><topic>Carcinogenicity</topic><topic>Carcinogens</topic><topic>Epithelium</topic><topic>Exposure</topic><topic>Exposure limits</topic><topic>Genotoxicity</topic><topic>Hyperplasia</topic><topic>indium tin oxide</topic><topic>Indium tin oxides</topic><topic>Inhalation</topic><topic>Invited Review</topic><topic>Lung carcinoma</topic><topic>Lungs</topic><topic>Macrophages</topic><topic>Multi wall carbon nanotubes</topic><topic>multi-walled carbon nanotube</topic><topic>Occupational exposure</topic><topic>occupational exposure limit values</topic><topic>Occupational health</topic><topic>phagocytic macrophage</topic><topic>Phagocytosis</topic><topic>rat pulmonary carcinogenicity</topic><topic>Respiration</topic><topic>Toxicity</topic><toplevel>online_resources</toplevel><creatorcontrib>FUKUSHIMA, Shoji</creatorcontrib><creatorcontrib>KASAI, Tatsuya</creatorcontrib><creatorcontrib>SENOH, Hideki</creatorcontrib><creatorcontrib>UMEDA, Yumi</creatorcontrib><creatorcontrib>MINE, Takashi</creatorcontrib><creatorcontrib>SASAKI, Toshiaki</creatorcontrib><creatorcontrib>KONDO, Hitomi</creatorcontrib><creatorcontrib>MATSUMOTO, Michiharu</creatorcontrib><creatorcontrib>AISO, Shigetoshi</creatorcontrib><creatorcontrib>Japan Bioassay Research Center (JBRC</creatorcontrib><creatorcontrib>Japan Organization of Occupational Health and Safety</creatorcontrib><creatorcontrib>Association for Promotion of Research on Risk Assessment</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUKUSHIMA, Shoji</au><au>KASAI, Tatsuya</au><au>SENOH, Hideki</au><au>UMEDA, Yumi</au><au>MINE, Takashi</au><au>SASAKI, Toshiaki</au><au>KONDO, Hitomi</au><au>MATSUMOTO, Michiharu</au><au>AISO, Shigetoshi</au><aucorp>Japan Bioassay Research Center (JBRC</aucorp><aucorp>Japan Organization of Occupational Health and Safety</aucorp><aucorp>Association for Promotion of Research on Risk Assessment</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>36</volume><issue>2</issue><spage>2022-0086</spage><epage>83</epage><pages>2022-0086-83</pages><artnum>2022-0086</artnum><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>In this review, we focus on the rat pulmonary carcinogenicity of two solid substances, fibrous multi-walled carbon nanotube (MWCNT) and particulate indium tin oxide (ITO). Inhalation exposure to MWNT-7, a type of MWCNTs, and ITO induced lung carcinogenicity in both male and female rats. Toxicity to the alveolar epithelium is induced by macrophages undergoing frustrated phagocytosis or frustrated degradation of engulfed particles (referred to as frustrated macrophages). Melted macrophage contents contribute significantly to development of hyperplasia of the alveolar epithelium, which eventually results in the induction of lung carcinoma. MWNT-7 and ITO induce secondary genotoxicity; consequently, a no-observed-adverse-effect level can be applied to these materials rather than benchmark doses that are used for non-threshold carcinogens. Thus, establishing occupational exposure limit values for MWNT-7 and ITO based on the existence of a carcinogenic threshold is reasonable.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><pmid>37101961</pmid><doi>10.1293/tox.2022-0086</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-9198 |
| ispartof | Journal of Toxicologic Pathology, 2022, pp.2022-0086 |
| issn | 0914-9198 1881-915X 1347-7404 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10123297 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Alveoli Carcinogenicity Carcinogens Epithelium Exposure Exposure limits Genotoxicity Hyperplasia indium tin oxide Indium tin oxides Inhalation Invited Review Lung carcinoma Lungs Macrophages Multi wall carbon nanotubes multi-walled carbon nanotube Occupational exposure occupational exposure limit values Occupational health phagocytic macrophage Phagocytosis rat pulmonary carcinogenicity Respiration Toxicity |
| title | Contribution of toxicological pathology to occupational health: lung carcinogenicity of fibrous and particulate substances in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T01%3A36%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Contribution%20of%20toxicological%20pathology%20to%20occupational%20health:%20lung%20carcinogenicity%20of%20fibrous%20and%20particulate%20substances%20in%20rats&rft.jtitle=Journal%20of%20Toxicologic%20Pathology&rft.au=FUKUSHIMA,%20Shoji&rft.aucorp=Japan%20Bioassay%20Research%20Center%20(JBRC&rft.date=2023-01-01&rft.volume=36&rft.issue=2&rft.spage=2022-0086&rft.epage=83&rft.pages=2022-0086-83&rft.artnum=2022-0086&rft.issn=0914-9198&rft.eissn=1881-915X&rft_id=info:doi/10.1293/tox.2022-0086&rft_dat=%3Cproquest_pubme%3E2806994239%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2837257028&rft_id=info:pmid/37101961&rfr_iscdi=true |