Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation
Neurofilament light chain (NfL) has recently been used as a biomarker of neurodegeneration. Although cerebrospinal fluid (CSF) NfL levels are hypothesized to affect blood NfL levels, whether blood NfL levels change independently of the CSF during peripheral nerve injury remains unclear. Thus, we eva...
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| Veröffentlicht in: | Journal of Toxicologic Pathology 2022, pp.2022-0110 |
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| container_title | Journal of Toxicologic Pathology |
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| creator | SANO, Tomoya MASUDA, Yasushi YASUNO, Hironobu WATANABE, Takeshi SHINOZAWA, Tadahiro |
| description | Neurofilament light chain (NfL) has recently been used as a biomarker of neurodegeneration. Although cerebrospinal fluid (CSF) NfL levels are hypothesized to affect blood NfL levels, whether blood NfL levels change independently of the CSF during peripheral nerve injury remains unclear. Thus, we evaluated the nervous tissues histopathology and serum and CSF NfL levels in partial sciatic nerve-ligated rats at 6 h and one, three, or seven days after the surgery. Sciatic and tibial nerve fiber damage was observed at 6 h after the surgery, and peaked at three days postoperatively. The serum NfL levels peaked 6 h to one day after ligation, but they tended to return to the normal seven days after ligation. However, the CSF NfL levels were unchanged throughout the study period. In conclusion, the comparative evaluation of serum and CSF NfL levels can provide useful information as biomarkers of nerve tissue damage and its distribution. |
| doi_str_mv | 10.1293/tox.2022-0110 |
| format | Article |
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Although cerebrospinal fluid (CSF) NfL levels are hypothesized to affect blood NfL levels, whether blood NfL levels change independently of the CSF during peripheral nerve injury remains unclear. Thus, we evaluated the nervous tissues histopathology and serum and CSF NfL levels in partial sciatic nerve-ligated rats at 6 h and one, three, or seven days after the surgery. Sciatic and tibial nerve fiber damage was observed at 6 h after the surgery, and peaked at three days postoperatively. The serum NfL levels peaked 6 h to one day after ligation, but they tended to return to the normal seven days after ligation. However, the CSF NfL levels were unchanged throughout the study period. In conclusion, the comparative evaluation of serum and CSF NfL levels can provide useful information as biomarkers of nerve tissue damage and its distribution.</description><identifier>ISSN: 0914-9198</identifier><identifier>EISSN: 1881-915X</identifier><identifier>EISSN: 1347-7404</identifier><identifier>DOI: 10.1293/tox.2022-0110</identifier><identifier>PMID: 37101960</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</publisher><subject>Biomarkers ; Blood ; Cerebrospinal fluid ; Comparative analysis ; Damage ; Histopathology ; Light levels ; Nervous tissues ; Neurodegeneration ; neurofilament light chain ; partial sciatic nerve ligation ; peripheral nerve injury ; Peripheral nerves ; rats ; Sciatic nerve ; Short Communication ; Surgery ; Tibial nerve</subject><ispartof>Journal of Toxicologic Pathology, 2022, pp.2022-0110</ispartof><rights>2022 The Japanese Society of Toxicologic Pathology</rights><rights>2023 The Japanese Society of Toxicologic Pathology.</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>2023 The Japanese Society of Toxicologic Pathology 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c722t-ed9809e9da566223a51918470ee39af5a89f6c3211e082e36ca028fea030ea203</citedby><cites>FETCH-LOGICAL-c722t-ed9809e9da566223a51918470ee39af5a89f6c3211e082e36ca028fea030ea203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123296/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123296/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37101960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANO, Tomoya</creatorcontrib><creatorcontrib>MASUDA, Yasushi</creatorcontrib><creatorcontrib>YASUNO, Hironobu</creatorcontrib><creatorcontrib>WATANABE, Takeshi</creatorcontrib><creatorcontrib>SHINOZAWA, Tadahiro</creatorcontrib><creatorcontrib>Takeda Pharmaceutical Company Limited</creatorcontrib><creatorcontrib>Drug Safety Research and Evaluation</creatorcontrib><creatorcontrib>Drug Metabolism and Pharmacokinetics Research Laboratories</creatorcontrib><title>Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation</title><title>Journal of Toxicologic Pathology</title><addtitle>J Toxicol Pathol</addtitle><description>Neurofilament light chain (NfL) has recently been used as a biomarker of neurodegeneration. Although cerebrospinal fluid (CSF) NfL levels are hypothesized to affect blood NfL levels, whether blood NfL levels change independently of the CSF during peripheral nerve injury remains unclear. Thus, we evaluated the nervous tissues histopathology and serum and CSF NfL levels in partial sciatic nerve-ligated rats at 6 h and one, three, or seven days after the surgery. Sciatic and tibial nerve fiber damage was observed at 6 h after the surgery, and peaked at three days postoperatively. The serum NfL levels peaked 6 h to one day after ligation, but they tended to return to the normal seven days after ligation. However, the CSF NfL levels were unchanged throughout the study period. In conclusion, the comparative evaluation of serum and CSF NfL levels can provide useful information as biomarkers of nerve tissue damage and its distribution.</description><subject>Biomarkers</subject><subject>Blood</subject><subject>Cerebrospinal fluid</subject><subject>Comparative analysis</subject><subject>Damage</subject><subject>Histopathology</subject><subject>Light levels</subject><subject>Nervous tissues</subject><subject>Neurodegeneration</subject><subject>neurofilament light chain</subject><subject>partial sciatic nerve ligation</subject><subject>peripheral nerve injury</subject><subject>Peripheral nerves</subject><subject>rats</subject><subject>Sciatic nerve</subject><subject>Short Communication</subject><subject>Surgery</subject><subject>Tibial nerve</subject><issn>0914-9198</issn><issn>1881-915X</issn><issn>1347-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkk2P0zAQhiMEYsvCkSuyxIVLlrGdD_uEUAULYiUuIHGzXGfSunLiYicV-zP4x0zobvm4JGP5yfvOzJuieM7higstX0_xx5UAIUrgHB4UK64ULzWvvz0sVqB5RbVWF8WTnPcAooVaPi4uZMuB6wZWxc91HA422ckfkdnRhtvsM4s9G3FOsffBDjhOLPjtbmJuZ_3IAh4xZEbVtEOWMc0Dfdkxhwk3KeaDJxnWh9l3C0TameV5s0c3YcemyMhv8oRk58nXkVUic7KgUxyfFo96GzI-u3tfFl_fv_uy_lDefL7-uH57U7pWiKnETivQqDtbN40Q0tZcc1W1gCi17WurdN84KThHUAJl4ywI1aMFCWgFyMvizUn3MG8G7ByNmWwwh-QHm25NtN78ezP6ndnGo6HVCSl0Qwqv7hRS_D5jnszgs8MQ7IhxzkYoaLSuOK8Iffkfuo9zoj0tlGxF3VQtJ6o8UY7WmBP25244mCVtQ2mbJW2zpE38i79HONP38RJwfQLo1jsb4hj8iH-8u06S4sEumtIAyAZIGhTJV_XyoO6VkmoZ4NNJaZ8nu8Wz1RKlC_i7MdsdqRED98W50TNFP1AyOMpfYZXbeg</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>SANO, Tomoya</creator><creator>MASUDA, Yasushi</creator><creator>YASUNO, Hironobu</creator><creator>WATANABE, Takeshi</creator><creator>SHINOZAWA, Tadahiro</creator><general>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</general><general>The Japanese Society of Toxicologic Pathology</general><general>Japan Science and Technology Agency</general><general>Japanese Society of Toxicologic Pathology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation</title><author>SANO, Tomoya ; MASUDA, Yasushi ; YASUNO, Hironobu ; WATANABE, Takeshi ; SHINOZAWA, Tadahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c722t-ed9809e9da566223a51918470ee39af5a89f6c3211e082e36ca028fea030ea203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Blood</topic><topic>Cerebrospinal fluid</topic><topic>Comparative analysis</topic><topic>Damage</topic><topic>Histopathology</topic><topic>Light levels</topic><topic>Nervous tissues</topic><topic>Neurodegeneration</topic><topic>neurofilament light chain</topic><topic>partial sciatic nerve ligation</topic><topic>peripheral nerve injury</topic><topic>Peripheral nerves</topic><topic>rats</topic><topic>Sciatic nerve</topic><topic>Short Communication</topic><topic>Surgery</topic><topic>Tibial nerve</topic><toplevel>online_resources</toplevel><creatorcontrib>SANO, Tomoya</creatorcontrib><creatorcontrib>MASUDA, Yasushi</creatorcontrib><creatorcontrib>YASUNO, Hironobu</creatorcontrib><creatorcontrib>WATANABE, Takeshi</creatorcontrib><creatorcontrib>SHINOZAWA, Tadahiro</creatorcontrib><creatorcontrib>Takeda Pharmaceutical Company Limited</creatorcontrib><creatorcontrib>Drug Safety Research and Evaluation</creatorcontrib><creatorcontrib>Drug Metabolism and Pharmacokinetics Research Laboratories</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Toxicologic Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANO, Tomoya</au><au>MASUDA, Yasushi</au><au>YASUNO, Hironobu</au><au>WATANABE, Takeshi</au><au>SHINOZAWA, Tadahiro</au><aucorp>Takeda Pharmaceutical Company Limited</aucorp><aucorp>Drug Safety Research and Evaluation</aucorp><aucorp>Drug Metabolism and Pharmacokinetics Research Laboratories</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation</atitle><jtitle>Journal of Toxicologic Pathology</jtitle><addtitle>J Toxicol Pathol</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>36</volume><issue>2</issue><spage>2022-0110</spage><epage>149</epage><pages>2022-0110-149</pages><artnum>2022-0110</artnum><issn>0914-9198</issn><eissn>1881-915X</eissn><eissn>1347-7404</eissn><abstract>Neurofilament light chain (NfL) has recently been used as a biomarker of neurodegeneration. Although cerebrospinal fluid (CSF) NfL levels are hypothesized to affect blood NfL levels, whether blood NfL levels change independently of the CSF during peripheral nerve injury remains unclear. Thus, we evaluated the nervous tissues histopathology and serum and CSF NfL levels in partial sciatic nerve-ligated rats at 6 h and one, three, or seven days after the surgery. Sciatic and tibial nerve fiber damage was observed at 6 h after the surgery, and peaked at three days postoperatively. The serum NfL levels peaked 6 h to one day after ligation, but they tended to return to the normal seven days after ligation. However, the CSF NfL levels were unchanged throughout the study period. In conclusion, the comparative evaluation of serum and CSF NfL levels can provide useful information as biomarkers of nerve tissue damage and its distribution.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY</pub><pmid>37101960</pmid><doi>10.1293/tox.2022-0110</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Blood Cerebrospinal fluid Comparative analysis Damage Histopathology Light levels Nervous tissues Neurodegeneration neurofilament light chain partial sciatic nerve ligation peripheral nerve injury Peripheral nerves rats Sciatic nerve Short Communication Surgery Tibial nerve |
| title | Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation |
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