Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy

Focused ultrasound (FUS) has the potential to modulate regional brain excitability and possibly aid seizure control; however, effects on behavior of FUS used as a seizure therapy are unknown. This study explores behavioral effects and hippocampal restoration induced by pulsed FUS in a kainic acid (K...

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Veröffentlicht in:	Neurotherapeutics 2023-03, Vol.20 (2), p.502-517
Hauptverfasser:	Chu, Po-Chun, Huang, Chen-Syuan, Ing, Shan-Zhi, Yu, Hsiang-Yu, Fisher, Robert S., Liu, Hao-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Animal models Animals Anxiety Atrophy Biomedical and Life Sciences Biomedicine Convulsions & seizures Disease Models, Animal Epilepsy Epilepsy - chemically induced Epilepsy - diagnostic imaging Epilepsy - therapy Excitability Hippocampus Kainic acid Kainic Acid - toxicity Learning Magnetic resonance imaging Male Neostriatum Neurobiology Neuroimaging Neurology Neuroprotection Neurosciences Neurosurgery Original Original Article Rats Rats, Sprague-Dawley Seizures Temporal lobe Ultrasonic imaging Ultrasound
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