Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma

Neuropathic pain following spinal cord injury (SCI) remains a difficult problem that affects more than 80% of SCI patients. Growing evidence indicates that neuroinflammatory responses play a key role in neuropathic pain after SCI. Short hairpin RNA (shRNA) interference is an efficient tool for the k...

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Veröffentlicht in:	Neurotherapeutics 2023-03, Vol.20 (2), p.564-577
Hauptverfasser:	Park, Jonghyuck, Farmer, Matthew, Casson, Camara, Kalashnikova, Irina, Kolpek, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ankyrins Biomedical and Life Sciences Biomedicine Cytotoxicity Dorsal horn Dorsal root ganglia Gene Silencing Genetic Vectors HEK293 Cells Humans Hypersensitivity Immunomodulation Inflammation Lentivirus - genetics Macrophages MAP kinase Neuralgia Neuralgia - genetics Neuralgia - therapy Neurobiology Neurology Neurosciences Neurosurgery Original Original Article Pain perception Rats Rats, Sprague-Dawley RNA, Small Interfering - genetics RNA-mediated interference Spinal cord Spinal cord injuries Spinal Cord Injuries - genetics Spinal Cord Injuries - therapy Transient receptor potential proteins
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