CT texture analysis reliability in pulmonary lesions: the influence of 3D vs. 2D lesion segmentation and volume definition by a Hounsfield-unit threshold

Objective Reproducibility problems are a known limitation of radiomics. The segmentation of the target lesion plays a critical role in texture analysis variability. This study’s aim was to compare the interobserver reliability of manual 2D vs. 3D lung lesion segmentation with and without pre-definit...

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