MDCT-findings in patients with non-occlusive mesenteric ischemia (NOMI): influence of vasoconstrictor agents

Objectives To evaluate the influence of vasoconstrictor agents (VCAs) on signs of vasoconstriction and bowel ischemia on MDCT detected in patients with non-occlusive mesenteric ischemia (NOMI). Methods This 8-year single-center retrospective study consecutively included all patients with histopathol...

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Veröffentlicht in:European radiology 2023-05, Vol.33 (5), p.3627-3637
Hauptverfasser: Topolsky, Antoine, Pantet, Olivier, Liaudet, Lucas, Sempoux, Christine, Denys, Alban, Knebel, Jean-François, Schmidt, Sabine
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container_end_page 3637
container_issue 5
container_start_page 3627
container_title European radiology
container_volume 33
creator Topolsky, Antoine
Pantet, Olivier
Liaudet, Lucas
Sempoux, Christine
Denys, Alban
Knebel, Jean-François
Schmidt, Sabine
description Objectives To evaluate the influence of vasoconstrictor agents (VCAs) on signs of vasoconstriction and bowel ischemia on MDCT detected in patients with non-occlusive mesenteric ischemia (NOMI). Methods This 8-year single-center retrospective study consecutively included all patients with histopathologically proven NOMI who underwent MDCT ≤ 48 h prior to surgical bowel resection. Two blinded radiologists jointly reviewed each examination for signs of bowel ischemia, abdominal organ infarct, mesenteric vessel size and regularity, and ancillary vascular findings. VCA administration (length and dosage), clinical and biochemical data, risk factors, and outcomes were retrieved from patients’ medical records. Subgroup comparisons were performed. Results Ninety patients were included (59 males, mean age 65 years); 40 (44.4%) had received VCAs before MDCT. Overall mortality was 32% ( n  = 29), with no significant difference between the two groups. In patients treated with VCAs, the calibre of the superior mesenteric artery (SMA) was smaller ( p  = 0.032), and vasoconstriction of its branches tended to be more important ( p  = 0.096) than in patients not treated with VCAs. The presence and extent of bowel ischemia did not significantly correlate with VCA administration, but abdominal organ infarcts tended to be more frequent ( p  = 0.005) and involved more organs ( p  = 0.088). The VCA group had lower mean arterial pressure ( p  = 0.006) and lower hemoglobin levels ( p  
doi_str_mv 10.1007/s00330-023-09415-4
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Methods This 8-year single-center retrospective study consecutively included all patients with histopathologically proven NOMI who underwent MDCT ≤ 48 h prior to surgical bowel resection. Two blinded radiologists jointly reviewed each examination for signs of bowel ischemia, abdominal organ infarct, mesenteric vessel size and regularity, and ancillary vascular findings. VCA administration (length and dosage), clinical and biochemical data, risk factors, and outcomes were retrieved from patients’ medical records. Subgroup comparisons were performed. Results Ninety patients were included (59 males, mean age 65 years); 40 (44.4%) had received VCAs before MDCT. Overall mortality was 32% ( n  = 29), with no significant difference between the two groups. In patients treated with VCAs, the calibre of the superior mesenteric artery (SMA) was smaller ( p  = 0.032), and vasoconstriction of its branches tended to be more important ( p  = 0.096) than in patients not treated with VCAs. The presence and extent of bowel ischemia did not significantly correlate with VCA administration, but abdominal organ infarcts tended to be more frequent ( p  = 0.005) and involved more organs ( p  = 0.088). The VCA group had lower mean arterial pressure ( p  = 0.006) and lower hemoglobin levels ( p  &lt; 0.001). Several biomarkers of organ failure and inflammation, differed significantly with VCA use, proving worse clinical condition. Conclusions MDCT demonstrates more severe SMA vasoconstriction and tends to show increased abdominal organ infarcts after VCA administration in NOMI patients compared to NOMI patients not treated with VCAs. Key Points • In critically ill patients with NOMI, MDCT demonstrates VCA support via increased vasoconstriction of the main SMA and its branches. • VCA administration in NOMI patients tends to contribute to the development of organ infarcts, as shown on MDCT. • An important degree of vasoconstriction in NOMI patients may indicate insufficient resuscitation and, thus, help clinicians in further patient management.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-023-09415-4</identifier><identifier>PMID: 36692594</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdomen ; Aged ; Biomarkers ; Blood pressure ; Blood vessels ; Diagnostic Radiology ; Gastrointestinal ; Hemoglobin ; Humans ; Imaging ; Infarction ; Internal Medicine ; Interventional Radiology ; Intestine ; Ischemia ; Ischemia - diagnostic imaging ; Male ; Medical records ; Medicine ; Medicine &amp; Public Health ; Mesenteric Ischemia - diagnostic imaging ; Neuroradiology ; Patients ; Radiology ; Retrospective Studies ; Risk factors ; Subgroups ; Tomography, X-Ray Computed ; Ultrasound ; Vasoconstriction ; Vasoconstrictor Agents - pharmacology ; Vasoconstrictor Agents - therapeutic use ; Vasoconstrictors</subject><ispartof>European radiology, 2023-05, Vol.33 (5), p.3627-3637</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Methods This 8-year single-center retrospective study consecutively included all patients with histopathologically proven NOMI who underwent MDCT ≤ 48 h prior to surgical bowel resection. Two blinded radiologists jointly reviewed each examination for signs of bowel ischemia, abdominal organ infarct, mesenteric vessel size and regularity, and ancillary vascular findings. VCA administration (length and dosage), clinical and biochemical data, risk factors, and outcomes were retrieved from patients’ medical records. Subgroup comparisons were performed. Results Ninety patients were included (59 males, mean age 65 years); 40 (44.4%) had received VCAs before MDCT. Overall mortality was 32% ( n  = 29), with no significant difference between the two groups. In patients treated with VCAs, the calibre of the superior mesenteric artery (SMA) was smaller ( p  = 0.032), and vasoconstriction of its branches tended to be more important ( p  = 0.096) than in patients not treated with VCAs. The presence and extent of bowel ischemia did not significantly correlate with VCA administration, but abdominal organ infarcts tended to be more frequent ( p  = 0.005) and involved more organs ( p  = 0.088). The VCA group had lower mean arterial pressure ( p  = 0.006) and lower hemoglobin levels ( p  &lt; 0.001). Several biomarkers of organ failure and inflammation, differed significantly with VCA use, proving worse clinical condition. Conclusions MDCT demonstrates more severe SMA vasoconstriction and tends to show increased abdominal organ infarcts after VCA administration in NOMI patients compared to NOMI patients not treated with VCAs. Key Points • In critically ill patients with NOMI, MDCT demonstrates VCA support via increased vasoconstriction of the main SMA and its branches. • VCA administration in NOMI patients tends to contribute to the development of organ infarcts, as shown on MDCT. • An important degree of vasoconstriction in NOMI patients may indicate insufficient resuscitation and, thus, help clinicians in further patient management.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Blood vessels</subject><subject>Diagnostic Radiology</subject><subject>Gastrointestinal</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infarction</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Intestine</subject><subject>Ischemia</subject><subject>Ischemia - diagnostic imaging</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine &amp; 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Topolsky, Antoine</au><au>Pantet, Olivier</au><au>Liaudet, Lucas</au><au>Sempoux, Christine</au><au>Denys, Alban</au><au>Knebel, Jean-François</au><au>Schmidt, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MDCT-findings in patients with non-occlusive mesenteric ischemia (NOMI): influence of vasoconstrictor agents</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>33</volume><issue>5</issue><spage>3627</spage><epage>3637</epage><pages>3627-3637</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives To evaluate the influence of vasoconstrictor agents (VCAs) on signs of vasoconstriction and bowel ischemia on MDCT detected in patients with non-occlusive mesenteric ischemia (NOMI). Methods This 8-year single-center retrospective study consecutively included all patients with histopathologically proven NOMI who underwent MDCT ≤ 48 h prior to surgical bowel resection. Two blinded radiologists jointly reviewed each examination for signs of bowel ischemia, abdominal organ infarct, mesenteric vessel size and regularity, and ancillary vascular findings. VCA administration (length and dosage), clinical and biochemical data, risk factors, and outcomes were retrieved from patients’ medical records. Subgroup comparisons were performed. Results Ninety patients were included (59 males, mean age 65 years); 40 (44.4%) had received VCAs before MDCT. Overall mortality was 32% ( n  = 29), with no significant difference between the two groups. In patients treated with VCAs, the calibre of the superior mesenteric artery (SMA) was smaller ( p  = 0.032), and vasoconstriction of its branches tended to be more important ( p  = 0.096) than in patients not treated with VCAs. The presence and extent of bowel ischemia did not significantly correlate with VCA administration, but abdominal organ infarcts tended to be more frequent ( p  = 0.005) and involved more organs ( p  = 0.088). The VCA group had lower mean arterial pressure ( p  = 0.006) and lower hemoglobin levels ( p  &lt; 0.001). Several biomarkers of organ failure and inflammation, differed significantly with VCA use, proving worse clinical condition. Conclusions MDCT demonstrates more severe SMA vasoconstriction and tends to show increased abdominal organ infarcts after VCA administration in NOMI patients compared to NOMI patients not treated with VCAs. Key Points • In critically ill patients with NOMI, MDCT demonstrates VCA support via increased vasoconstriction of the main SMA and its branches. • VCA administration in NOMI patients tends to contribute to the development of organ infarcts, as shown on MDCT. • An important degree of vasoconstriction in NOMI patients may indicate insufficient resuscitation and, thus, help clinicians in further patient management.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36692594</pmid><doi>10.1007/s00330-023-09415-4</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2631-3032</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; SpringerNature Journals
subjects Abdomen
Aged
Biomarkers
Blood pressure
Blood vessels
Diagnostic Radiology
Gastrointestinal
Hemoglobin
Humans
Imaging
Infarction
Internal Medicine
Interventional Radiology
Intestine
Ischemia
Ischemia - diagnostic imaging
Male
Medical records
Medicine
Medicine & Public Health
Mesenteric Ischemia - diagnostic imaging
Neuroradiology
Patients
Radiology
Retrospective Studies
Risk factors
Subgroups
Tomography, X-Ray Computed
Ultrasound
Vasoconstriction
Vasoconstrictor Agents - pharmacology
Vasoconstrictor Agents - therapeutic use
Vasoconstrictors
title MDCT-findings in patients with non-occlusive mesenteric ischemia (NOMI): influence of vasoconstrictor agents
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