Immunotherapy of genital warts with inosine pranobex (Imunovir): preliminary study
One hundred and sixty five heterosexual men and women with genital warts were treated with inosine pranobex (Imunovir) or conventional treatment, or both. Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts...
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| Veröffentlicht in: | Genitourinary Medicine 1986-10, Vol.62 (5), p.352-355 |
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| container_title | Genitourinary Medicine |
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| creator | Mohanty, K C Scott, C S |
| description | One hundred and sixty five heterosexual men and women with genital warts were treated with inosine pranobex (Imunovir) or conventional treatment, or both. Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts of a shorter duration. Supplementation of conventional treatment with inosine pranobex increased the success rate from 41% to 94%. Immunological studies in 134 patients with genital warts showed an increased number of B cells in 21% of peripheral blood samples. Absence of major defects among circulating lymphocytes suggested that patients with genital warts may have a local immune reaction. |
| doi_str_mv | 10.1136/sti.62.5.352 |
| format | Article |
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Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts of a shorter duration. Supplementation of conventional treatment with inosine pranobex increased the success rate from 41% to 94%. Immunological studies in 134 patients with genital warts showed an increased number of B cells in 21% of peripheral blood samples. Absence of major defects among circulating lymphocytes suggested that patients with genital warts may have a local immune reaction.</description><identifier>ISSN: 0266-4348</identifier><identifier>ISSN: 1368-4973</identifier><identifier>EISSN: 1472-3263</identifier><identifier>DOI: 10.1136/sti.62.5.352</identifier><identifier>PMID: 2429908</identifier><identifier>CODEN: GEMEE2</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Adult ; Biological and medical sciences ; Clinical Trials as Topic ; Female ; Genital Diseases, Female - therapy ; Genital Diseases, Male - therapy ; Humans ; Immunomodulators ; Inosine - analogs & derivatives ; Inosine Pranobex - therapeutic use ; Male ; Medical sciences ; Pharmacology. 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Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts of a shorter duration. Supplementation of conventional treatment with inosine pranobex increased the success rate from 41% to 94%. Immunological studies in 134 patients with genital warts showed an increased number of B cells in 21% of peripheral blood samples. Absence of major defects among circulating lymphocytes suggested that patients with genital warts may have a local immune reaction.</description><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Genital Diseases, Female - therapy</subject><subject>Genital Diseases, Male - therapy</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Inosine - analogs & derivatives</subject><subject>Inosine Pranobex - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Podophyllin - therapeutic use</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Warts - therapy</subject><issn>0266-4348</issn><issn>1368-4973</issn><issn>1472-3263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkduLEzEYxYMoa62--SoMKF7AqblffBC0eOmyKCvqa8jMpNt0Z5KaZHa3_70pLUV9UAgEcn45nO87ADxEcIYQ4a9SdjOOZ2xGGL4FJogKXBPMyW0wgZjzmhIq74J7Ka0hhFwwdQJOMMVKQTkBXxfDMPqQVzaazbYKy-rCepdNX12bmFN17fKqcj4k5221icaHxt5Uzxe7T1cuvnhdHm3vBudN3FYpj932PrizNH2yDw73FHz_8P7b_FN99uXjYv72rG6YQLlmrFHMwsZaqsrpDOw6aqUgEBtMO2osQbiDsm0kXipmFKGmky0WVErIkSVT8GbvuxmbwXat9TmaXm-iG0oWHYzTfyrerfRFuNIIIlSmLwZPDwYx_BxtynpwqbV9b7wNY9JCIEgk-T9YVk645LiAj_8C12GMvmxBIyGgwkLgnd3LPdXGkFK0y2NmBPWuUl0q1RxrpkulBX_0-5xH-NBh0Z8cdJNa0y9LSa1LR0woqHhxnYJ6j7mU7c1RNvFSc0EE059_zPU5end6zk6RpoV_tuebYf3vgL8A-XPF7g</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Mohanty, K C</creator><creator>Scott, C S</creator><general>BMJ Publishing Group Ltd</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19861001</creationdate><title>Immunotherapy of genital warts with inosine pranobex (Imunovir): preliminary study</title><author>Mohanty, K C ; Scott, C S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b571t-55b95e0bee49e49da0dd4e87302a24d4ae312d08cb82f95a934ad8c27488061e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Genital Diseases, Female - therapy</topic><topic>Genital Diseases, Male - therapy</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Inosine - analogs & derivatives</topic><topic>Inosine Pranobex - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0266-4348 |
| ispartof | Genitourinary Medicine, 1986-10, Vol.62 (5), p.352-355 |
| issn | 0266-4348 1368-4973 1472-3263 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1011990 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic - therapeutic use Adult Biological and medical sciences Clinical Trials as Topic Female Genital Diseases, Female - therapy Genital Diseases, Male - therapy Humans Immunomodulators Inosine - analogs & derivatives Inosine Pranobex - therapeutic use Male Medical sciences Pharmacology. Drug treatments Podophyllin - therapeutic use Prospective Studies Random Allocation Warts - therapy |
| title | Immunotherapy of genital warts with inosine pranobex (Imunovir): preliminary study |
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