Neural Predictors of Improvement With Cognitive Behavioral Therapy for Adolescents With Depression: An Examination of Reward Responsiveness and Emotion Regulation

Earlier depression onsets are associated with more debilitating courses and poorer life quality, highlighting the importance of effective early intervention. Many youths fail to improve with evidence-based treatments for depression, likely due in part to heterogeneity within the disorder. Multi-meth...

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Veröffentlicht in:Journal of abnormal child psychology 2023-08, Vol.51 (8), p.1069-1082
Hauptverfasser: Dickey, Lindsay, Pegg, Samantha, Cárdenas, Emilia F., Green, Haley, Dao, Anh, Waxmonsky, James, Pérez-Edgar, Koraly, Kujawa, Autumn
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container_title Journal of abnormal child psychology
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creator Dickey, Lindsay
Pegg, Samantha
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Pérez-Edgar, Koraly
Kujawa, Autumn
description Earlier depression onsets are associated with more debilitating courses and poorer life quality, highlighting the importance of effective early intervention. Many youths fail to improve with evidence-based treatments for depression, likely due in part to heterogeneity within the disorder. Multi-method assessment of individual differences in positive and negative emotion processing could improve predictions of treatment outcomes. The current study examined self-report and neurophysiological measures of reward responsiveness and emotion regulation as predictors of response to cognitive-behavioral therapy (CBT). Adolescents (14–18 years) with depression ( N  = 70) completed monetary reward and emotion regulation tasks while electroencephalogram (EEG) was recorded, and self-report measures of reward responsiveness, emotion regulation, and depressive symptoms at intake. Adolescents then completed a 16-session group CBT program, with depressive symptoms and clinician-rated improvement assessed across treatment. Lower reward positivity amplitudes, reflecting reduced neural reward responsiveness, predicted lower depressive symptoms with treatment. Larger late positive potential residuals during reappraisal, potentially reflecting difficulty with emotion regulation, predicted greater clinician-rated improvement. Self-report measures were not significant predictors. Results support the clinical utility of EEG measures, with impairments in positive and negative emotion processing predicting greater change with interventions that target these processes.
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subjects Adolescent
Adolescents
Behavior modification
Behavioral Science and Psychology
Child and School Psychology
Clinical outcomes
Cognitive behavioral therapy
Cognitive Behavioral Therapy - methods
Cognitive Restructuring
Cognitive therapy
Cognitive-behavioral factors
Depression
Early intervention
Electroencephalography
Emotional Regulation
Emotions - physiology
Evidence-based medicine
Humans
Individual differences
Mental depression
Neurosciences
Outcomes of Treatment
Positive emotions
Psychology
Public Health
Responsiveness
Reward
Self report
Teenagers
title Neural Predictors of Improvement With Cognitive Behavioral Therapy for Adolescents With Depression: An Examination of Reward Responsiveness and Emotion Regulation
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