Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank

Several breast cancer susceptibility genes have been discovered, but more are likely to exist. To identify additional breast cancer susceptibility genes, we used the founder population of Poland and performed whole-exome sequencing on 510 women with familial breast cancer and 308 control subjects. W...

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Veröffentlicht in:	American journal of human genetics 2023-04, Vol.110 (4), p.648-662
Hauptverfasser:	Cybulski, Cezary, Zamani, Neda, Kluźniak, Wojciech, Milano, Larissa, Wokołorczyk, Dominika, Stempa, Klaudia, Rudnicka, Helena, Zhang, Shiyu, Zadeh, Maryam, Huzarski, Tomasz, Jakubowska, Anna, Dębniak, Tadeusz, Lener, Marcin, Szwiec, Marek, Domagała, Paweł, Samani, Amir Abbas, Narod, Steven, Gronwald, Jacek, Masson, Jean-Yves, Lubiński, Jan, Akbari, Mohammad R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics ATRIP Biological Specimen Banks Breast Neoplasms - genetics Cell Cycle Proteins - genetics DNA Damage DNA-Binding Proteins - genetics Female hereditary breast cancer homologous recombination deficiency Humans loss of heterozygosity Poland - epidemiology Polish population Replication Protein A - genetics Replication Protein A - metabolism UK Biobank United Kingdom - epidemiology
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