Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to study and treat the central nervous system. This is due in part to the scarcity of targets known to mediate BBB crossing. To identify novel targets, we leverage a panel of adeno-associated viruses (AAVs) previ...

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Veröffentlicht in:	Science advances 2023-04, Vol.9 (16), p.eadg6618-eadg6618
Hauptverfasser:	Shay, Timothy F, Sullivan, Erin E, Ding, Xiaozhe, Chen, Xinhong, Ravindra Kumar, Sripriya, Goertsen, David, Brown, David, Crosby, Anaya, Vielmetter, Jost, Borsos, Máté, Wolfe, Damien A, Lam, Annie W, Gradinaru, Viviana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Brain - metabolism Carbonic Anhydrase IV - genetics Carbonic Anhydrase IV - metabolism Dependovirus - genetics Dependovirus - metabolism Gene Transfer Techniques Humans Mice Neuroscience Primates - genetics SciAdv r-articles
Online-Zugang:	Volltext
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