BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson's disease using low-intensity focus ultrasound in adult macaqu...

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Veröffentlicht in:	Science advances 2023-04, Vol.9 (16), p.eadf4888-eadf4888
Hauptverfasser:	Blesa, Javier, Pineda-Pardo, José A, Inoue, Ken-Ichi, Gasca-Salas, Carmen, Balzano, Tiziano, Del Rey, Natalia López-González, Reinares-Sebastián, Alejandro, Esteban-García, Noelia, Rodríguez-Rojas, Rafael, Márquez, Raquel, Ciorraga, María, Del Álamo, Marta, García-Cañamaque, Lina, Ruiz de Aguiar, Santiago, Rachmilevitch, Itay, Trigo-Damas, Inés, Takada, Masahiko, Obeso, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Brain - metabolism Diseases and Disorders Macaca Magnetic Resonance Imaging Neuroscience Parkinson Disease - diagnostic imaging Parkinson Disease - genetics Parkinson Disease - therapy Positron-Emission Tomography SciAdv r-articles
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