Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer

Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.

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Veröffentlicht in:Cancer cell 2023-05, Vol.41 (5), p.821-823
Hauptverfasser: Wu, Mary Y., Shepherd, Scott T.C., Fendler, Annika, Carr, Edward J., Au, Lewis, Harvey, Ruth, Dowgier, Giulia, Hobbs, Agnieszka, Herman, Lou S., Ragno, Martina, Adams, Lorin, Schmitt, Andreas M., Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, O’Reilly, Nicola, Bawumia, Philip, Smith, Callie, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Hepworth, Stephanie, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Williams, Bryan, Brown, Michael, Caidan, Simon, Gavrielides, Mike, MacRae, James I., Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O’Flaherty, Molly, Popat, Sanjay, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J.S., Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L.V., Kassiotis, George, Howell, Michael, Walker, Susanna, Nicholson, Emma, Larkin, James, Wall, Emma C., Turajlic, Samra
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container_end_page 823
container_issue 5
container_start_page 821
container_title Cancer cell
container_volume 41
creator Wu, Mary Y.
Shepherd, Scott T.C.
Fendler, Annika
Carr, Edward J.
Au, Lewis
Harvey, Ruth
Dowgier, Giulia
Hobbs, Agnieszka
Herman, Lou S.
Ragno, Martina
Adams, Lorin
Schmitt, Andreas M.
Tippu, Zayd
Shum, Benjamin
Farag, Sheima
Rogiers, Aljosja
O’Reilly, Nicola
Bawumia, Philip
Smith, Callie
Carlyle, Eleanor
Edmonds, Kim
Del Rosario, Lyra
Lingard, Karla
Mangwende, Mary
Holt, Lucy
Ahmod, Hamid
Korteweg, Justine
Foley, Tara
Barber, Taja
Hepworth, Stephanie
Emslie-Henry, Andrea
Caulfield-Lynch, Niamh
Byrne, Fiona
Deng, Daqi
Williams, Bryan
Brown, Michael
Caidan, Simon
Gavrielides, Mike
MacRae, James I.
Kelly, Gavin
Peat, Kema
Kelly, Denise
Murra, Aida
Kelly, Kayleigh
O’Flaherty, Molly
Popat, Sanjay
Yousaf, Nadia
Jhanji, Shaman
Tatham, Kate
Cunningham, David
Van As, Nicholas
Young, Kate
Furness, Andrew J.S.
Pickering, Lisa
Beale, Rupert
Swanton, Charles
Gandhi, Sonia
Gamblin, Steve
Bauer, David L.V.
Kassiotis, George
Howell, Michael
Walker, Susanna
Nicholson, Emma
Larkin, James
Wall, Emma C.
Turajlic, Samra
description Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.
doi_str_mv 10.1016/j.ccell.2023.04.005
format Article
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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Mary Y.</au><au>Shepherd, Scott T.C.</au><au>Fendler, Annika</au><au>Carr, Edward J.</au><au>Au, Lewis</au><au>Harvey, Ruth</au><au>Dowgier, Giulia</au><au>Hobbs, Agnieszka</au><au>Herman, Lou S.</au><au>Ragno, Martina</au><au>Adams, Lorin</au><au>Schmitt, Andreas M.</au><au>Tippu, Zayd</au><au>Shum, Benjamin</au><au>Farag, Sheima</au><au>Rogiers, Aljosja</au><au>O’Reilly, Nicola</au><au>Bawumia, Philip</au><au>Smith, Callie</au><au>Carlyle, Eleanor</au><au>Edmonds, Kim</au><au>Del Rosario, Lyra</au><au>Lingard, Karla</au><au>Mangwende, Mary</au><au>Holt, Lucy</au><au>Ahmod, Hamid</au><au>Korteweg, Justine</au><au>Foley, Tara</au><au>Barber, Taja</au><au>Hepworth, Stephanie</au><au>Emslie-Henry, Andrea</au><au>Caulfield-Lynch, Niamh</au><au>Byrne, Fiona</au><au>Deng, Daqi</au><au>Williams, Bryan</au><au>Brown, Michael</au><au>Caidan, Simon</au><au>Gavrielides, Mike</au><au>MacRae, James I.</au><au>Kelly, Gavin</au><au>Peat, Kema</au><au>Kelly, Denise</au><au>Murra, Aida</au><au>Kelly, Kayleigh</au><au>O’Flaherty, Molly</au><au>Popat, Sanjay</au><au>Yousaf, Nadia</au><au>Jhanji, Shaman</au><au>Tatham, Kate</au><au>Cunningham, David</au><au>Van As, Nicholas</au><au>Young, Kate</au><au>Furness, Andrew J.S.</au><au>Pickering, Lisa</au><au>Beale, Rupert</au><au>Swanton, Charles</au><au>Gandhi, Sonia</au><au>Gamblin, Steve</au><au>Bauer, David L.V.</au><au>Kassiotis, George</au><au>Howell, Michael</au><au>Walker, Susanna</au><au>Nicholson, Emma</au><au>Larkin, James</au><au>Wall, Emma C.</au><au>Turajlic, Samra</au><aucorp>the CAPTURE consortium</aucorp><aucorp>CAPTURE consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2023-05-08</date><risdate>2023</risdate><volume>41</volume><issue>5</issue><spage>821</spage><epage>823</epage><pages>821-823</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37116490</pmid><doi>10.1016/j.ccell.2023.04.005</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
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subjects COVID-19
Hematologic Neoplasms - drug therapy
Humans
Letter
Neoplasms
SARS-CoV-2
title Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer
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